Soluble C-Type Lectin-Like Receptor 2 Elevation in Patients with Acute Cerebral Infarction
Background: Acute cerebral infarction (ACI) includes cardiogenic ACI treated with anticoagulants and atherosclerotic ACI treated with antiplatelet agents. The differential diagnosis between cardiogenic and atherosclerotic ACI is still difficult. Materials and Methods: The plasma sCLEC-2 and D-dimer...
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| Veröffentlicht in: | Journal of clinical medicine 2021-07, Vol.10 (15), p.3408 |
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| creator | Nishigaki, Akisato Ichikawa, Yuhuko Ezaki, Minoru Yamamoto, Akitaka Suzuki, Kenji Tachibana, Kei Kamon, Toshitaka Horie, Shotaro Masuda, Jun Makino, Katsutoshi Shiraki, Katsuya Shimpo, Hideto Shimaoka, Motomu Suzuki-Inoue, Katsue Wada, Hideo |
| description | Background: Acute cerebral infarction (ACI) includes cardiogenic ACI treated with anticoagulants and atherosclerotic ACI treated with antiplatelet agents. The differential diagnosis between cardiogenic and atherosclerotic ACI is still difficult. Materials and Methods: The plasma sCLEC-2 and D-dimer levels were measured using the STACIA system. Results: The plasma sCLEC-2 level was significantly high in patients with ACI, especially those in patients with atherosclerotic or lacunar ACI, and plasma D-dimer levels were significantly high in patients with cardioembolic ACI. The plasma levels of sCLEC-2 and the sCLEC-2/D-dimer ratios in patients with atherosclerotic or lacunar ACI were significantly higher than those in patients with cardioembolic ACI. The plasma D-dimer levels in patients with atherosclerotic or lacunar ACI were significantly lower than those in patients with cardioembolic ACI. The plasma levels of sCLEC-2 and the sCLEC-2/D-dimer ratios were significantly higher in patients with atherosclerotic or lacunar ACI or acute myocardial infarction in comparison to patients with cardioembolic ACI or those with deep vein thrombosis. Conclusion: Using both the plasma sCLEC-2 and D-dimer levels may be useful for the diagnosis of ACI, and differentiating between atherosclerotic and cardioembolic ACI. |
| doi_str_mv | 10.3390/jcm10153408 |
| format | Article |
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The differential diagnosis between cardiogenic and atherosclerotic ACI is still difficult. Materials and Methods: The plasma sCLEC-2 and D-dimer levels were measured using the STACIA system. Results: The plasma sCLEC-2 level was significantly high in patients with ACI, especially those in patients with atherosclerotic or lacunar ACI, and plasma D-dimer levels were significantly high in patients with cardioembolic ACI. The plasma levels of sCLEC-2 and the sCLEC-2/D-dimer ratios in patients with atherosclerotic or lacunar ACI were significantly higher than those in patients with cardioembolic ACI. The plasma D-dimer levels in patients with atherosclerotic or lacunar ACI were significantly lower than those in patients with cardioembolic ACI. The plasma levels of sCLEC-2 and the sCLEC-2/D-dimer ratios were significantly higher in patients with atherosclerotic or lacunar ACI or acute myocardial infarction in comparison to patients with cardioembolic ACI or those with deep vein thrombosis. Conclusion: Using both the plasma sCLEC-2 and D-dimer levels may be useful for the diagnosis of ACI, and differentiating between atherosclerotic and cardioembolic ACI.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm10153408</identifier><identifier>PMID: 34362190</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Acute coronary syndromes ; Adenosine ; Anemia ; Anticoagulants ; Atherosclerosis ; Biomarkers ; Blood platelets ; Clinical medicine ; Digestive system ; Disease ; Heart attacks ; Heart failure ; Lectins ; Monoclonal antibodies ; Patients ; Plasma ; Proteins ; Pulmonary embolisms ; Purpura ; Stroke ; Thrombosis ; Transient ischemic attack</subject><ispartof>Journal of clinical medicine, 2021-07, Vol.10 (15), p.3408</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-5db8daa8e999da7c15b860a52220e414ec1a3b544ecd8e635ef9c418f06f309a3</citedby><cites>FETCH-LOGICAL-c386t-5db8daa8e999da7c15b860a52220e414ec1a3b544ecd8e635ef9c418f06f309a3</cites><orcidid>0000-0003-1930-3397 ; 0000-0001-9021-8633</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348423/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348423/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27904,27905,53771,53773</link.rule.ids></links><search><creatorcontrib>Nishigaki, Akisato</creatorcontrib><creatorcontrib>Ichikawa, Yuhuko</creatorcontrib><creatorcontrib>Ezaki, Minoru</creatorcontrib><creatorcontrib>Yamamoto, Akitaka</creatorcontrib><creatorcontrib>Suzuki, Kenji</creatorcontrib><creatorcontrib>Tachibana, Kei</creatorcontrib><creatorcontrib>Kamon, Toshitaka</creatorcontrib><creatorcontrib>Horie, Shotaro</creatorcontrib><creatorcontrib>Masuda, Jun</creatorcontrib><creatorcontrib>Makino, Katsutoshi</creatorcontrib><creatorcontrib>Shiraki, Katsuya</creatorcontrib><creatorcontrib>Shimpo, Hideto</creatorcontrib><creatorcontrib>Shimaoka, Motomu</creatorcontrib><creatorcontrib>Suzuki-Inoue, Katsue</creatorcontrib><creatorcontrib>Wada, Hideo</creatorcontrib><title>Soluble C-Type Lectin-Like Receptor 2 Elevation in Patients with Acute Cerebral Infarction</title><title>Journal of clinical medicine</title><description>Background: Acute cerebral infarction (ACI) includes cardiogenic ACI treated with anticoagulants and atherosclerotic ACI treated with antiplatelet agents. The differential diagnosis between cardiogenic and atherosclerotic ACI is still difficult. Materials and Methods: The plasma sCLEC-2 and D-dimer levels were measured using the STACIA system. Results: The plasma sCLEC-2 level was significantly high in patients with ACI, especially those in patients with atherosclerotic or lacunar ACI, and plasma D-dimer levels were significantly high in patients with cardioembolic ACI. The plasma levels of sCLEC-2 and the sCLEC-2/D-dimer ratios in patients with atherosclerotic or lacunar ACI were significantly higher than those in patients with cardioembolic ACI. The plasma D-dimer levels in patients with atherosclerotic or lacunar ACI were significantly lower than those in patients with cardioembolic ACI. The plasma levels of sCLEC-2 and the sCLEC-2/D-dimer ratios were significantly higher in patients with atherosclerotic or lacunar ACI or acute myocardial infarction in comparison to patients with cardioembolic ACI or those with deep vein thrombosis. Conclusion: Using both the plasma sCLEC-2 and D-dimer levels may be useful for the diagnosis of ACI, and differentiating between atherosclerotic and cardioembolic ACI.</description><subject>Acute coronary syndromes</subject><subject>Adenosine</subject><subject>Anemia</subject><subject>Anticoagulants</subject><subject>Atherosclerosis</subject><subject>Biomarkers</subject><subject>Blood platelets</subject><subject>Clinical medicine</subject><subject>Digestive system</subject><subject>Disease</subject><subject>Heart attacks</subject><subject>Heart failure</subject><subject>Lectins</subject><subject>Monoclonal antibodies</subject><subject>Patients</subject><subject>Plasma</subject><subject>Proteins</subject><subject>Pulmonary embolisms</subject><subject>Purpura</subject><subject>Stroke</subject><subject>Thrombosis</subject><subject>Transient ischemic attack</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkVFLIzEUhcOiqGif_AOBfVmQ0WRuMk1eFqToWigo6r7sS8hk7qzpTic1man47zfFImpecuB-OZybQ8gpZ-cAml0s3YozLkEw9Y0clWw6LRgo2PugD8kkpSXLRylR8ukBOQQBVck1OyJ_HkI31h3SWfH4uka6QDf4vlj4f0jv0eF6CJGW9KrDjR186Knv6V1W2A-JvvjhiV66ccjPMWIdbUfnfWuj26InZL-1XcLJ7j4mv6-vHmc3xeL213x2uSgcqGooZFOrxlqFWuvGTh2XtaqYlWVZMhRcoOMWaimyaBRWILHVTnDVsqoFpi0ck59vvuuxXmHjcrQcxKyjX9n4aoL15vOk90_mb9gYBSJ_CGSDHzuDGJ5HTINZ-eSw62yPYUymlFIL0JVUGf3-BV2GMfZ5vS2lFGRSZOrsjXIxpBSxfQ_DmdnWZj7UBv8BBuaI1A</recordid><startdate>20210730</startdate><enddate>20210730</enddate><creator>Nishigaki, Akisato</creator><creator>Ichikawa, Yuhuko</creator><creator>Ezaki, Minoru</creator><creator>Yamamoto, Akitaka</creator><creator>Suzuki, Kenji</creator><creator>Tachibana, Kei</creator><creator>Kamon, Toshitaka</creator><creator>Horie, Shotaro</creator><creator>Masuda, Jun</creator><creator>Makino, Katsutoshi</creator><creator>Shiraki, Katsuya</creator><creator>Shimpo, Hideto</creator><creator>Shimaoka, Motomu</creator><creator>Suzuki-Inoue, Katsue</creator><creator>Wada, Hideo</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1930-3397</orcidid><orcidid>https://orcid.org/0000-0001-9021-8633</orcidid></search><sort><creationdate>20210730</creationdate><title>Soluble C-Type Lectin-Like Receptor 2 Elevation in Patients with Acute Cerebral Infarction</title><author>Nishigaki, Akisato ; Ichikawa, Yuhuko ; Ezaki, Minoru ; Yamamoto, Akitaka ; Suzuki, Kenji ; Tachibana, Kei ; Kamon, Toshitaka ; Horie, Shotaro ; Masuda, Jun ; Makino, Katsutoshi ; Shiraki, Katsuya ; Shimpo, Hideto ; Shimaoka, Motomu ; Suzuki-Inoue, Katsue ; Wada, Hideo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-5db8daa8e999da7c15b860a52220e414ec1a3b544ecd8e635ef9c418f06f309a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acute coronary syndromes</topic><topic>Adenosine</topic><topic>Anemia</topic><topic>Anticoagulants</topic><topic>Atherosclerosis</topic><topic>Biomarkers</topic><topic>Blood platelets</topic><topic>Clinical medicine</topic><topic>Digestive system</topic><topic>Disease</topic><topic>Heart attacks</topic><topic>Heart failure</topic><topic>Lectins</topic><topic>Monoclonal antibodies</topic><topic>Patients</topic><topic>Plasma</topic><topic>Proteins</topic><topic>Pulmonary embolisms</topic><topic>Purpura</topic><topic>Stroke</topic><topic>Thrombosis</topic><topic>Transient ischemic attack</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishigaki, Akisato</creatorcontrib><creatorcontrib>Ichikawa, Yuhuko</creatorcontrib><creatorcontrib>Ezaki, Minoru</creatorcontrib><creatorcontrib>Yamamoto, Akitaka</creatorcontrib><creatorcontrib>Suzuki, Kenji</creatorcontrib><creatorcontrib>Tachibana, Kei</creatorcontrib><creatorcontrib>Kamon, Toshitaka</creatorcontrib><creatorcontrib>Horie, Shotaro</creatorcontrib><creatorcontrib>Masuda, Jun</creatorcontrib><creatorcontrib>Makino, Katsutoshi</creatorcontrib><creatorcontrib>Shiraki, Katsuya</creatorcontrib><creatorcontrib>Shimpo, Hideto</creatorcontrib><creatorcontrib>Shimaoka, Motomu</creatorcontrib><creatorcontrib>Suzuki-Inoue, Katsue</creatorcontrib><creatorcontrib>Wada, Hideo</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishigaki, Akisato</au><au>Ichikawa, Yuhuko</au><au>Ezaki, Minoru</au><au>Yamamoto, Akitaka</au><au>Suzuki, Kenji</au><au>Tachibana, Kei</au><au>Kamon, Toshitaka</au><au>Horie, Shotaro</au><au>Masuda, Jun</au><au>Makino, Katsutoshi</au><au>Shiraki, Katsuya</au><au>Shimpo, Hideto</au><au>Shimaoka, Motomu</au><au>Suzuki-Inoue, Katsue</au><au>Wada, Hideo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soluble C-Type Lectin-Like Receptor 2 Elevation in Patients with Acute Cerebral Infarction</atitle><jtitle>Journal of clinical medicine</jtitle><date>2021-07-30</date><risdate>2021</risdate><volume>10</volume><issue>15</issue><spage>3408</spage><pages>3408-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Background: Acute cerebral infarction (ACI) includes cardiogenic ACI treated with anticoagulants and atherosclerotic ACI treated with antiplatelet agents. The differential diagnosis between cardiogenic and atherosclerotic ACI is still difficult. Materials and Methods: The plasma sCLEC-2 and D-dimer levels were measured using the STACIA system. Results: The plasma sCLEC-2 level was significantly high in patients with ACI, especially those in patients with atherosclerotic or lacunar ACI, and plasma D-dimer levels were significantly high in patients with cardioembolic ACI. The plasma levels of sCLEC-2 and the sCLEC-2/D-dimer ratios in patients with atherosclerotic or lacunar ACI were significantly higher than those in patients with cardioembolic ACI. The plasma D-dimer levels in patients with atherosclerotic or lacunar ACI were significantly lower than those in patients with cardioembolic ACI. The plasma levels of sCLEC-2 and the sCLEC-2/D-dimer ratios were significantly higher in patients with atherosclerotic or lacunar ACI or acute myocardial infarction in comparison to patients with cardioembolic ACI or those with deep vein thrombosis. Conclusion: Using both the plasma sCLEC-2 and D-dimer levels may be useful for the diagnosis of ACI, and differentiating between atherosclerotic and cardioembolic ACI.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>34362190</pmid><doi>10.3390/jcm10153408</doi><orcidid>https://orcid.org/0000-0003-1930-3397</orcidid><orcidid>https://orcid.org/0000-0001-9021-8633</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acute coronary syndromes Adenosine Anemia Anticoagulants Atherosclerosis Biomarkers Blood platelets Clinical medicine Digestive system Disease Heart attacks Heart failure Lectins Monoclonal antibodies Patients Plasma Proteins Pulmonary embolisms Purpura Stroke Thrombosis Transient ischemic attack |
| title | Soluble C-Type Lectin-Like Receptor 2 Elevation in Patients with Acute Cerebral Infarction |
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