The effects of graded calorie restriction XVII: Multitissue metabolomics reveals synthesis of carnitine and NAD, and tRNA charging as key pathways

The evolutionary context of why caloric restriction (CR) activates physiological mechanisms that slow the process of aging remains unclear. The main goal of this analysis was to identify, using metabolomics, the common pathways that are modulated across multiple tissues (brown adipose tissue, liver,...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-08, Vol.118 (31), p.1-11
Hauptverfasser:	García-Flores, Libia Alejandra, Green, Cara L., Mitchell, Sharon E., Promislow, Daniel E. L., Lusseau, David, Douglas, Alex, Speakman, John R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Adipose tissue Adipose tissue (brown) Aging Animal Feed - analysis Animals Biological Sciences Biosynthesis Caloric Restriction Carboxylic acids Carnitine Carnitine - biosynthesis Charging Clean energy Diet - veterinary Dietary restrictions Energy Metabolism - physiology Gene Expression Regulation - physiology INAUGURAL ARTICLE Lipid metabolism Lipids Male Metabolism Metabolites Metabolomics Mice Mice, Inbred C57BL NAD NAD - biosynthesis Nicotinamide Nicotinamide adenine dinucleotide Nutrient deficiency Random Allocation RNA, Transfer - genetics RNA, Transfer - metabolism Tissue Distribution Transfer RNA tRNA Trp Tryptophan
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