PKM2 Regulates HSP90-Mediated Stability of the IGF-1R Precursor Protein and Promotes Cancer Cell Survival during Hypoxia

Insulin-like growth factor-1 receptor (IGF-1R), an important factor in promoting cancer cell growth and survival, is commonly upregulated in cancer cells. However, amplification of the IGF1R gene is extremely rare in tumors. Here, we have provided insights into the mechanisms underlying the regulati...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancers 2021-07, Vol.13 (15), p.3850
Hauptverfasser:	Koo, Han, Byun, Sangwon, Seo, Jieun, Jung, Yuri, Lee, Dong Chul, Cho, Jung Hee, Park, Young Soo, Yeom, Young Il, Park, Kyung Chan
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Apoptosis Cancer Cell cycle Cell death Cell growth Cell survival DNA microarrays Experiments Gene amplification Hsp90 protein Hypoxia Insulin Insulin-like growth factor I Insulin-like growth factor I receptors Insulin-like growth factors Kinases Lung cancer Medical prognosis Phosphorylation Proteins Reagents Serine Solid tumors Therapeutic applications Therapeutic targets Tumorigenesis Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!