Reversing neural circuit and behavior deficit in mice exposed to maternal inflammation by Zika virus

Zika virus (ZIKV) infection during pregnancy is linked to various developmental brain disorders. Infants who are asymptomatic at birth might have postnatal neurocognitive complications. However, animal models recapitulating these neurocognitive phenotypes are lacking, and the circuit mechanism under...

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Veröffentlicht in:	EMBO reports 2021-08, Vol.22 (8), p.e51978-n/a
Hauptverfasser:	Ma, Li, Wang, Jing, Ge, Jianlong, Wang, Yuan, Zhang, Wei, Du, Yuanning, Luo, Jun, Li, Yangping, Wang, Feng, Fan, Guoping, Chen, Rong, Yao, Bing, Zhao, Zhen, Guo, Ming-Lei, Kim, Woong-Ki, Chai, Yang, Chen, Jian-Fu
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Animal models Autism Brain chemogenetics Circuits Cognition EMBO23 EMBO24 EMBO27 Exposure Fetuses Grooming Hippocampus Immune response Infections Inflammation Innervation mouse behaviors neural circuit Neurodevelopmental disorders Neurons Offspring Phenotypes Prefrontal cortex Pregnancy Synapses Vector-borne diseases Viruses Zika virus
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