Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model

Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that affects more than 44 million people worldwide. Despite the high disease burden, there is no effective treatment for people suffering from AD. Mesenchymal stem cells (MSCs) are multipotent stromal cells that have been wi...

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Veröffentlicht in:	Theranostics 2021-01, Vol.11 (17), p.8129-8142
Hauptverfasser:	Cone, Allaura S, Yuan, Xuegang, Sun, Li, Duke, Leanne C, Vreones, Michael P, Carrier, Allison N, Kenyon, Stephanie M, Carver, Spencer R, Benthem, Sarah D, Stimmell, Alina C, Moseley, Shawn C, Hike, David, Grant, Samuel C, Wilber, Aaron A, Olcese, James M, Meckes, Jr, David G
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - therapy Alzheimer's disease Amyloid beta-Peptides - metabolism Animals Apoptosis Bone marrow Brain - metabolism Disease Models, Animal Extracellular vesicles Extracellular Vesicles - metabolism Hippocampus - metabolism Homeostasis Hypotheses Immunomodulation Inflammation Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells - metabolism Mice Mice, Transgenic Microscopy Mutation Plaque, Amyloid - metabolism Polyethylene glycol Proteins Research Paper Stem cells
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