Platelet MHC class I mediates CD8+ T-cell suppression during sepsis

Circulating platelets interact with leukocytes to modulate host immune and thrombotic responses. In sepsis, platelet-leukocyte interactions are increased and have been associated with adverse clinical events, including increased platelet–T-cell interactions. Sepsis is associated with reduced CD8+ T-...

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Veröffentlicht in:	Blood 2021-08, Vol.138 (5), p.401-416
Hauptverfasser:	Guo, Li, Shen, Sikui, Rowley, Jesse W., Tolley, Neal D., Jia, Wenwen, Manne, Bhanu Kanth, McComas, Kyra N., Bolingbroke, Ben, Kosaka, Yasuhiro, Krauel, Krystin, Denorme, Frederik, Jacob, Shancy P., Eustes, Alicia S., Campbell, Robert A., Middleton, Elizabeth A., He, Xiao, Brown, Samuel M., Morrell, Craig N., Weyrich, Andrew S., Rondina, Matthew T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals CD8-Positive T-Lymphocytes - immunology Cell Proliferation Female Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology Humans Immune Tolerance Immunobiology and Immunotherapy Male Mice Mice, Knockout Platelets and Thrombopoiesis Prospective Studies Sepsis - genetics Sepsis - immunology Thrombosis and Hemostasis
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