Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome

Immunotherapies targeting aspects of T cell functionality are efficacious in many solid tumors, but pancreatic ductal adenocarcinoma (PDAC) remains refractory to these treatments. Deeper understanding of the PDAC immune ecosystem is needed to identify additional therapeutic targets and predictive bi...

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Veröffentlicht in:	Cancer discovery 2021-08, Vol.11 (8), p.2014-2031
Hauptverfasser:	Liudahl, Shannon M, Betts, Courtney B, Sivagnanam, Shamilene, Morales-Oyarvide, Vicente, da Silva, Annacarolina, Yuan, Chen, Hwang, Samuel, Grossblatt-Wait, Alison, Leis, Kenna R, Larson, William, Lavoie, Meghan B, Robinson, Padraic, Dias Costa, Andressa, Väyrynen, Sara A, Clancy, Thomas E, Rubinson, Douglas A, Link, Jason, Keith, Dove, Horton, Wesley, Tempero, Margaret A, Vonderheide, Robert H, Jaffee, Elizabeth M, Sheppard, Brett, Goecks, Jeremy, Sears, Rosalie C, Park, Byung S, Mori, Motomi, Nowak, Jonathan A, Wolpin, Brian M, Coussens, Lisa M
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Pancreatic Ductal - pathology Carcinoma, Pancreatic Ductal - therapy Humans Immunotherapy Leukocytes - pathology Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy Tumor Microenvironment
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