Multiple sclerosis lesions: relationship between MR enhancement pattern and magnetization transfer effect
To investigate the relationship between the enhancement pattern of a multiple sclerosis lesion and its magnetization transfer effect. Fifty-four lesions were chosen from 29 patients with multiple sclerosis on the basis of enhancement pattern on contrast-enhanced T1-weighted MR images. They included...
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| Veröffentlicht in: | American journal of neuroradiology : AJNR 1996-06, Vol.17 (6), p.1041-1050 |
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| creator | Petrella, JR Grossman, RI McGowan, JC Campbell, G Cohen, JA |
| description | To investigate the relationship between the enhancement pattern of a multiple sclerosis lesion and its magnetization transfer effect.
Fifty-four lesions were chosen from 29 patients with multiple sclerosis on the basis of enhancement pattern on contrast-enhanced T1-weighted MR images. They included 14 homogeneously enhancing lesions, 26 nonenhancing lesions, and 14 ring-enhancing lesions. Magnetization transfer ratios of the homogeneously enhancing lesions, nonenhancing lesions, and central portion of the ring-enhancing lesions were measured. Means were calculated and compared.
The magnetization transfer ratios for homogeneously enhancing lesions were higher (mean, 32.2%; SD, 3.4%) than those for nonenhancing lesions (mean 29.4%; SD, 4.3%) and for the central portion of ring-enhancing lesions (mean, 24.5%; SD, 4.0%). Significant differences were found between the ring-enhancing lesions and the homogeneously enhancing lesions and between the ring-enhancing lesions and the nonenhancing lesions.
We found a relationship between decreased magnetization transfer ratios and those enhancement patterns in which myelin is known to be decreased histopathologically. Thus, use of the magnetization transfer technique may increase the specificity of MR imaging in assessing the extent of residual myelination in multiple sclerosis lesions. |
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Fifty-four lesions were chosen from 29 patients with multiple sclerosis on the basis of enhancement pattern on contrast-enhanced T1-weighted MR images. They included 14 homogeneously enhancing lesions, 26 nonenhancing lesions, and 14 ring-enhancing lesions. Magnetization transfer ratios of the homogeneously enhancing lesions, nonenhancing lesions, and central portion of the ring-enhancing lesions were measured. Means were calculated and compared.
The magnetization transfer ratios for homogeneously enhancing lesions were higher (mean, 32.2%; SD, 3.4%) than those for nonenhancing lesions (mean 29.4%; SD, 4.3%) and for the central portion of ring-enhancing lesions (mean, 24.5%; SD, 4.0%). Significant differences were found between the ring-enhancing lesions and the homogeneously enhancing lesions and between the ring-enhancing lesions and the nonenhancing lesions.
We found a relationship between decreased magnetization transfer ratios and those enhancement patterns in which myelin is known to be decreased histopathologically. Thus, use of the magnetization transfer technique may increase the specificity of MR imaging in assessing the extent of residual myelination in multiple sclerosis lesions.</description><identifier>ISSN: 0195-6108</identifier><identifier>EISSN: 1936-959X</identifier><identifier>PMID: 8791914</identifier><identifier>CODEN: AAJNDL</identifier><language>eng</language><publisher>Oak Brook, IL: Am Soc Neuroradiology</publisher><subject>Biological and medical sciences ; Blood-Brain Barrier - physiology ; Brain - pathology ; Brain Edema - diagnosis ; Contrast Media ; Drug Combinations ; Extravasation of Diagnostic and Therapeutic Materials - diagnosis ; Gadolinium DTPA ; Humans ; Image Enhancement ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging - methods ; Medical sciences ; Meglumine ; Multiple Sclerosis - diagnosis ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Nerve Fibers, Myelinated - pathology ; Neurology ; Organometallic Compounds ; Pentetic Acid - analogs & derivatives ; Research Support, U.S. Gov't, P.H.S</subject><ispartof>American journal of neuroradiology : AJNR, 1996-06, Vol.17 (6), p.1041-1050</ispartof><rights>1996 INIST-CNRS</rights><rights>Copyright © American Society of Neuroradiology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338596/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338596/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3130107$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8791914$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petrella, JR</creatorcontrib><creatorcontrib>Grossman, RI</creatorcontrib><creatorcontrib>McGowan, JC</creatorcontrib><creatorcontrib>Campbell, G</creatorcontrib><creatorcontrib>Cohen, JA</creatorcontrib><title>Multiple sclerosis lesions: relationship between MR enhancement pattern and magnetization transfer effect</title><title>American journal of neuroradiology : AJNR</title><addtitle>AJNR Am J Neuroradiol</addtitle><description>To investigate the relationship between the enhancement pattern of a multiple sclerosis lesion and its magnetization transfer effect.
Fifty-four lesions were chosen from 29 patients with multiple sclerosis on the basis of enhancement pattern on contrast-enhanced T1-weighted MR images. They included 14 homogeneously enhancing lesions, 26 nonenhancing lesions, and 14 ring-enhancing lesions. Magnetization transfer ratios of the homogeneously enhancing lesions, nonenhancing lesions, and central portion of the ring-enhancing lesions were measured. Means were calculated and compared.
The magnetization transfer ratios for homogeneously enhancing lesions were higher (mean, 32.2%; SD, 3.4%) than those for nonenhancing lesions (mean 29.4%; SD, 4.3%) and for the central portion of ring-enhancing lesions (mean, 24.5%; SD, 4.0%). Significant differences were found between the ring-enhancing lesions and the homogeneously enhancing lesions and between the ring-enhancing lesions and the nonenhancing lesions.
We found a relationship between decreased magnetization transfer ratios and those enhancement patterns in which myelin is known to be decreased histopathologically. Thus, use of the magnetization transfer technique may increase the specificity of MR imaging in assessing the extent of residual myelination in multiple sclerosis lesions.</description><subject>Biological and medical sciences</subject><subject>Blood-Brain Barrier - physiology</subject><subject>Brain - pathology</subject><subject>Brain Edema - diagnosis</subject><subject>Contrast Media</subject><subject>Drug Combinations</subject><subject>Extravasation of Diagnostic and Therapeutic Materials - diagnosis</subject><subject>Gadolinium DTPA</subject><subject>Humans</subject><subject>Image Enhancement</subject><subject>Image Processing, Computer-Assisted</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical sciences</subject><subject>Meglumine</subject><subject>Multiple Sclerosis - diagnosis</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Nerve Fibers, Myelinated - pathology</subject><subject>Neurology</subject><subject>Organometallic Compounds</subject><subject>Pentetic Acid - analogs & derivatives</subject><subject>Research Support, U.S. Gov't, P.H.S</subject><issn>0195-6108</issn><issn>1936-959X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9rFTEQxRextNfqRxDyIL4t5M9mk_hQkKKt0FIQhb6F2dzZu5Fsdk1yXeqn79ZeWn3yaQbOmd8cZl5UG2ZEWxtpbl9WG8qMrFtG9Un1KucflFJpFD-ujrUyzLBmU_nrfSh-DkiyC5im7DMJmP0U8weSMEB5aAc_kw7LghjJ9VeCcYDocMRYyAylYIoE4paMsItY_O8_Q6QkiLnHRLDv0ZXX1VEPIeObQz2tvn_-9O38sr66ufhy_vGqHoTkpWZSOY2cNS3qRoPqpBTruOo7x0Xr0DhpoOGGcsl5zzV0Wmyh40y1otsKFKfV2SN33ncjbt0aMkGwc_IjpDs7gbf_KtEPdjf9sloILU27At4fAGn6ucdc7OizwxAg4rTPVmlBm0Y3_zUyqZXmrV6Nb_-O9JTl8IVVf3fQITsI_Xo45_OTTTBBGVXP-wa_Gxaf0OYRQlihzC7LwpRtLaMNE_cgRqID</recordid><startdate>19960601</startdate><enddate>19960601</enddate><creator>Petrella, JR</creator><creator>Grossman, RI</creator><creator>McGowan, JC</creator><creator>Campbell, G</creator><creator>Cohen, JA</creator><general>Am Soc Neuroradiology</general><general>American Society of Neuroradiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19960601</creationdate><title>Multiple sclerosis lesions: relationship between MR enhancement pattern and magnetization transfer effect</title><author>Petrella, JR ; Grossman, RI ; McGowan, JC ; Campbell, G ; Cohen, JA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h352t-157c8e2146e848a7b553fec7fbc236ce9c59a42902522f28ab83dab21763bd3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Biological and medical sciences</topic><topic>Blood-Brain Barrier - physiology</topic><topic>Brain - pathology</topic><topic>Brain Edema - diagnosis</topic><topic>Contrast Media</topic><topic>Drug Combinations</topic><topic>Extravasation of Diagnostic and Therapeutic Materials - diagnosis</topic><topic>Gadolinium DTPA</topic><topic>Humans</topic><topic>Image Enhancement</topic><topic>Image Processing, Computer-Assisted</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medical sciences</topic><topic>Meglumine</topic><topic>Multiple Sclerosis - diagnosis</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Nerve Fibers, Myelinated - pathology</topic><topic>Neurology</topic><topic>Organometallic Compounds</topic><topic>Pentetic Acid - analogs & derivatives</topic><topic>Research Support, U.S. Gov't, P.H.S</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petrella, JR</creatorcontrib><creatorcontrib>Grossman, RI</creatorcontrib><creatorcontrib>McGowan, JC</creatorcontrib><creatorcontrib>Campbell, G</creatorcontrib><creatorcontrib>Cohen, JA</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of neuroradiology : AJNR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petrella, JR</au><au>Grossman, RI</au><au>McGowan, JC</au><au>Campbell, G</au><au>Cohen, JA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple sclerosis lesions: relationship between MR enhancement pattern and magnetization transfer effect</atitle><jtitle>American journal of neuroradiology : AJNR</jtitle><addtitle>AJNR Am J Neuroradiol</addtitle><date>1996-06-01</date><risdate>1996</risdate><volume>17</volume><issue>6</issue><spage>1041</spage><epage>1050</epage><pages>1041-1050</pages><issn>0195-6108</issn><eissn>1936-959X</eissn><coden>AAJNDL</coden><abstract>To investigate the relationship between the enhancement pattern of a multiple sclerosis lesion and its magnetization transfer effect.
Fifty-four lesions were chosen from 29 patients with multiple sclerosis on the basis of enhancement pattern on contrast-enhanced T1-weighted MR images. They included 14 homogeneously enhancing lesions, 26 nonenhancing lesions, and 14 ring-enhancing lesions. Magnetization transfer ratios of the homogeneously enhancing lesions, nonenhancing lesions, and central portion of the ring-enhancing lesions were measured. Means were calculated and compared.
The magnetization transfer ratios for homogeneously enhancing lesions were higher (mean, 32.2%; SD, 3.4%) than those for nonenhancing lesions (mean 29.4%; SD, 4.3%) and for the central portion of ring-enhancing lesions (mean, 24.5%; SD, 4.0%). Significant differences were found between the ring-enhancing lesions and the homogeneously enhancing lesions and between the ring-enhancing lesions and the nonenhancing lesions.
We found a relationship between decreased magnetization transfer ratios and those enhancement patterns in which myelin is known to be decreased histopathologically. Thus, use of the magnetization transfer technique may increase the specificity of MR imaging in assessing the extent of residual myelination in multiple sclerosis lesions.</abstract><cop>Oak Brook, IL</cop><pub>Am Soc Neuroradiology</pub><pmid>8791914</pmid><tpages>10</tpages></addata></record> |
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| issn | 0195-6108 1936-959X |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Biological and medical sciences Blood-Brain Barrier - physiology Brain - pathology Brain Edema - diagnosis Contrast Media Drug Combinations Extravasation of Diagnostic and Therapeutic Materials - diagnosis Gadolinium DTPA Humans Image Enhancement Image Processing, Computer-Assisted Magnetic Resonance Imaging - methods Medical sciences Meglumine Multiple Sclerosis - diagnosis Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Nerve Fibers, Myelinated - pathology Neurology Organometallic Compounds Pentetic Acid - analogs & derivatives Research Support, U.S. Gov't, P.H.S |
| title | Multiple sclerosis lesions: relationship between MR enhancement pattern and magnetization transfer effect |
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