Multimodal sensory evaluation of neuropathic spinal cord injury pain: an experimental study
Study design An experimental study. Objectives To investigate the changes in somatosensory functions using the combined application of quantitative sensory testing (QST), contact heat-evoked potentials (CHEPs) and laser-evoked potentials (LEPs) studies in individuals with spinal cord injury (SCI) in...
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| Veröffentlicht in: | Spinal cord 2021-08, Vol.59 (8), p.842-854 |
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| creator | Opsommer, Emmanuelle Korogod, Natalya Stockinger, Lenka Landmann, Gunther |
| description | Study design
An experimental study.
Objectives
To investigate the changes in somatosensory functions using the combined application of quantitative sensory testing (QST), contact heat-evoked potentials (CHEPs) and laser-evoked potentials (LEPs) studies in individuals with spinal cord injury (SCI) in relation to neuropathic pain (NeP).
Setting
Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.
Methods
Individuals with SCI were compared: 12 with NeP (SCI NeP) and 12 without NeP (SCI no NeP). Tools used were QST, CHEPs, LEPs and self-reported questionnaires. Tests were applied to the control (hand) and test (dermatome of altered sensation) sites, and compared to the able-bodied group.
Results
QST, LEPs and CHEPs assessments showed abnormalities both on the test and control sites, which did not differ between the groups with SCI. QST showed higher prevalence of allodynia in SCI NeP. CHEPs and LEPs demonstrated diminished amplitudes in both groups with SCI in comparison to able-bodied individuals. Only reaction time (RT) analysis revealed the difference of SCI NeP from the other two groups, expressed in partially preserved responses to the laser C-fibre stimulations.
Conclusions
Combination of assessments in our study allowed to examine spinothalamic and dorsal column functions in individuals with SCI. Changes in QST, CHEPs and LEPs were detected below the level of injury independent of NeP and at the control site indicating modifications in sensory processing rostral to the spinal lesion. Analysis of RT during laser stimulation could be an essential component when evaluating the somatosensory functions related to NeP in persons with SCI. |
| doi_str_mv | 10.1038/s41393-020-00607-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8338558</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2557914351</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-967f109fc7dce61a7fb4e67fc78e6b375528b393a722c91df41df2df51988d233</originalsourceid><addsrcrecordid>eNp9kTtvFDEUhS0URB7wByiikdLQTPBzbFNEiiJIkIJooKKwvB5P4tWsPbHHUTa_nht2WSAFhWXL97vH9_gg9JbgU4KZel84YZq1mOIW4w7L9vEFOiBcdq3oKN-DM-toy4HZR4elLDHGmmj1Cu0zxnmnGT9AP77UcQ6r1NuxKT6WlNeNv7djtXNIsUlDE33NabLzbXBNmUIE0KXcNyEuK8CTDfFDY2PjHyafw8rH-Ulqrv36NXo52LH4N9v9CH3_9PHbxVV7_fXy88X5deu45HOrOzkQrAcne-c7YuWw4B7unFS-WzApBFULMGElpU6TfuCwaD8I8KJ6ytgROtvoTnWx8iAS52xHM8E0Nq9NssH8W4nh1tyke6MYU0IoEHi3Fcjprvoym1Uozo-jjT7VYiiXSmhJhAb05Bm6TDXDpwAlhNSEM0GAohvK5VRK9sNuGILNU3Zmk52B7Myv7MwjNB3_bWPX8jssANgGKFCKNz7_efs_sj8BSJKnpg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2557914351</pqid></control><display><type>article</type><title>Multimodal sensory evaluation of neuropathic spinal cord injury pain: an experimental study</title><source>SpringerLink Journals - AutoHoldings</source><creator>Opsommer, Emmanuelle ; Korogod, Natalya ; Stockinger, Lenka ; Landmann, Gunther</creator><creatorcontrib>Opsommer, Emmanuelle ; Korogod, Natalya ; Stockinger, Lenka ; Landmann, Gunther</creatorcontrib><description>Study design
An experimental study.
Objectives
To investigate the changes in somatosensory functions using the combined application of quantitative sensory testing (QST), contact heat-evoked potentials (CHEPs) and laser-evoked potentials (LEPs) studies in individuals with spinal cord injury (SCI) in relation to neuropathic pain (NeP).
Setting
Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.
Methods
Individuals with SCI were compared: 12 with NeP (SCI NeP) and 12 without NeP (SCI no NeP). Tools used were QST, CHEPs, LEPs and self-reported questionnaires. Tests were applied to the control (hand) and test (dermatome of altered sensation) sites, and compared to the able-bodied group.
Results
QST, LEPs and CHEPs assessments showed abnormalities both on the test and control sites, which did not differ between the groups with SCI. QST showed higher prevalence of allodynia in SCI NeP. CHEPs and LEPs demonstrated diminished amplitudes in both groups with SCI in comparison to able-bodied individuals. Only reaction time (RT) analysis revealed the difference of SCI NeP from the other two groups, expressed in partially preserved responses to the laser C-fibre stimulations.
Conclusions
Combination of assessments in our study allowed to examine spinothalamic and dorsal column functions in individuals with SCI. Changes in QST, CHEPs and LEPs were detected below the level of injury independent of NeP and at the control site indicating modifications in sensory processing rostral to the spinal lesion. Analysis of RT during laser stimulation could be an essential component when evaluating the somatosensory functions related to NeP in persons with SCI.</description><identifier>ISSN: 1362-4393</identifier><identifier>EISSN: 1476-5624</identifier><identifier>DOI: 10.1038/s41393-020-00607-z</identifier><identifier>PMID: 33446934</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/1807/410/2610 ; 692/308 ; 692/617 ; Abnormalities ; Anatomy ; Assessments ; Biomedical and Life Sciences ; Biomedicine ; Contact potentials ; Evaluation ; Evoked potentials ; Human Physiology ; Information processing ; Lasers ; Neuralgia ; Neurochemistry ; Neuropsychology ; Neurosciences ; Pain ; Pain perception ; Paralysis ; Paraplegics ; Reaction time ; Sensory evaluation ; Sensory integration ; Sensory testing ; Spinal cord injuries</subject><ispartof>Spinal cord, 2021-08, Vol.59 (8), p.842-854</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-967f109fc7dce61a7fb4e67fc78e6b375528b393a722c91df41df2df51988d233</citedby><cites>FETCH-LOGICAL-c474t-967f109fc7dce61a7fb4e67fc78e6b375528b393a722c91df41df2df51988d233</cites><orcidid>0000-0002-3049-2283 ; 0000-0002-2018-2820</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41393-020-00607-z$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41393-020-00607-z$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33446934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Opsommer, Emmanuelle</creatorcontrib><creatorcontrib>Korogod, Natalya</creatorcontrib><creatorcontrib>Stockinger, Lenka</creatorcontrib><creatorcontrib>Landmann, Gunther</creatorcontrib><title>Multimodal sensory evaluation of neuropathic spinal cord injury pain: an experimental study</title><title>Spinal cord</title><addtitle>Spinal Cord</addtitle><addtitle>Spinal Cord</addtitle><description>Study design
An experimental study.
Objectives
To investigate the changes in somatosensory functions using the combined application of quantitative sensory testing (QST), contact heat-evoked potentials (CHEPs) and laser-evoked potentials (LEPs) studies in individuals with spinal cord injury (SCI) in relation to neuropathic pain (NeP).
Setting
Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.
Methods
Individuals with SCI were compared: 12 with NeP (SCI NeP) and 12 without NeP (SCI no NeP). Tools used were QST, CHEPs, LEPs and self-reported questionnaires. Tests were applied to the control (hand) and test (dermatome of altered sensation) sites, and compared to the able-bodied group.
Results
QST, LEPs and CHEPs assessments showed abnormalities both on the test and control sites, which did not differ between the groups with SCI. QST showed higher prevalence of allodynia in SCI NeP. CHEPs and LEPs demonstrated diminished amplitudes in both groups with SCI in comparison to able-bodied individuals. Only reaction time (RT) analysis revealed the difference of SCI NeP from the other two groups, expressed in partially preserved responses to the laser C-fibre stimulations.
Conclusions
Combination of assessments in our study allowed to examine spinothalamic and dorsal column functions in individuals with SCI. Changes in QST, CHEPs and LEPs were detected below the level of injury independent of NeP and at the control site indicating modifications in sensory processing rostral to the spinal lesion. Analysis of RT during laser stimulation could be an essential component when evaluating the somatosensory functions related to NeP in persons with SCI.</description><subject>692/1807/410/2610</subject><subject>692/308</subject><subject>692/617</subject><subject>Abnormalities</subject><subject>Anatomy</subject><subject>Assessments</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Contact potentials</subject><subject>Evaluation</subject><subject>Evoked potentials</subject><subject>Human Physiology</subject><subject>Information processing</subject><subject>Lasers</subject><subject>Neuralgia</subject><subject>Neurochemistry</subject><subject>Neuropsychology</subject><subject>Neurosciences</subject><subject>Pain</subject><subject>Pain perception</subject><subject>Paralysis</subject><subject>Paraplegics</subject><subject>Reaction time</subject><subject>Sensory evaluation</subject><subject>Sensory integration</subject><subject>Sensory testing</subject><subject>Spinal cord injuries</subject><issn>1362-4393</issn><issn>1476-5624</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kTtvFDEUhS0URB7wByiikdLQTPBzbFNEiiJIkIJooKKwvB5P4tWsPbHHUTa_nht2WSAFhWXL97vH9_gg9JbgU4KZel84YZq1mOIW4w7L9vEFOiBcdq3oKN-DM-toy4HZR4elLDHGmmj1Cu0zxnmnGT9AP77UcQ6r1NuxKT6WlNeNv7djtXNIsUlDE33NabLzbXBNmUIE0KXcNyEuK8CTDfFDY2PjHyafw8rH-Ulqrv36NXo52LH4N9v9CH3_9PHbxVV7_fXy88X5deu45HOrOzkQrAcne-c7YuWw4B7unFS-WzApBFULMGElpU6TfuCwaD8I8KJ6ytgROtvoTnWx8iAS52xHM8E0Nq9NssH8W4nh1tyke6MYU0IoEHi3Fcjprvoym1Uozo-jjT7VYiiXSmhJhAb05Bm6TDXDpwAlhNSEM0GAohvK5VRK9sNuGILNU3Zmk52B7Myv7MwjNB3_bWPX8jssANgGKFCKNz7_efs_sj8BSJKnpg</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Opsommer, Emmanuelle</creator><creator>Korogod, Natalya</creator><creator>Stockinger, Lenka</creator><creator>Landmann, Gunther</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3049-2283</orcidid><orcidid>https://orcid.org/0000-0002-2018-2820</orcidid></search><sort><creationdate>20210801</creationdate><title>Multimodal sensory evaluation of neuropathic spinal cord injury pain: an experimental study</title><author>Opsommer, Emmanuelle ; Korogod, Natalya ; Stockinger, Lenka ; Landmann, Gunther</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-967f109fc7dce61a7fb4e67fc78e6b375528b393a722c91df41df2df51988d233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>692/1807/410/2610</topic><topic>692/308</topic><topic>692/617</topic><topic>Abnormalities</topic><topic>Anatomy</topic><topic>Assessments</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Contact potentials</topic><topic>Evaluation</topic><topic>Evoked potentials</topic><topic>Human Physiology</topic><topic>Information processing</topic><topic>Lasers</topic><topic>Neuralgia</topic><topic>Neurochemistry</topic><topic>Neuropsychology</topic><topic>Neurosciences</topic><topic>Pain</topic><topic>Pain perception</topic><topic>Paralysis</topic><topic>Paraplegics</topic><topic>Reaction time</topic><topic>Sensory evaluation</topic><topic>Sensory integration</topic><topic>Sensory testing</topic><topic>Spinal cord injuries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Opsommer, Emmanuelle</creatorcontrib><creatorcontrib>Korogod, Natalya</creatorcontrib><creatorcontrib>Stockinger, Lenka</creatorcontrib><creatorcontrib>Landmann, Gunther</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Spinal cord</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Opsommer, Emmanuelle</au><au>Korogod, Natalya</au><au>Stockinger, Lenka</au><au>Landmann, Gunther</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multimodal sensory evaluation of neuropathic spinal cord injury pain: an experimental study</atitle><jtitle>Spinal cord</jtitle><stitle>Spinal Cord</stitle><addtitle>Spinal Cord</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>59</volume><issue>8</issue><spage>842</spage><epage>854</epage><pages>842-854</pages><issn>1362-4393</issn><eissn>1476-5624</eissn><abstract>Study design
An experimental study.
Objectives
To investigate the changes in somatosensory functions using the combined application of quantitative sensory testing (QST), contact heat-evoked potentials (CHEPs) and laser-evoked potentials (LEPs) studies in individuals with spinal cord injury (SCI) in relation to neuropathic pain (NeP).
Setting
Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.
Methods
Individuals with SCI were compared: 12 with NeP (SCI NeP) and 12 without NeP (SCI no NeP). Tools used were QST, CHEPs, LEPs and self-reported questionnaires. Tests were applied to the control (hand) and test (dermatome of altered sensation) sites, and compared to the able-bodied group.
Results
QST, LEPs and CHEPs assessments showed abnormalities both on the test and control sites, which did not differ between the groups with SCI. QST showed higher prevalence of allodynia in SCI NeP. CHEPs and LEPs demonstrated diminished amplitudes in both groups with SCI in comparison to able-bodied individuals. Only reaction time (RT) analysis revealed the difference of SCI NeP from the other two groups, expressed in partially preserved responses to the laser C-fibre stimulations.
Conclusions
Combination of assessments in our study allowed to examine spinothalamic and dorsal column functions in individuals with SCI. Changes in QST, CHEPs and LEPs were detected below the level of injury independent of NeP and at the control site indicating modifications in sensory processing rostral to the spinal lesion. Analysis of RT during laser stimulation could be an essential component when evaluating the somatosensory functions related to NeP in persons with SCI.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33446934</pmid><doi>10.1038/s41393-020-00607-z</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-3049-2283</orcidid><orcidid>https://orcid.org/0000-0002-2018-2820</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Spinal cord, 2021-08, Vol.59 (8), p.842-854 |
| issn | 1362-4393 1476-5624 |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | 692/1807/410/2610 692/308 692/617 Abnormalities Anatomy Assessments Biomedical and Life Sciences Biomedicine Contact potentials Evaluation Evoked potentials Human Physiology Information processing Lasers Neuralgia Neurochemistry Neuropsychology Neurosciences Pain Pain perception Paralysis Paraplegics Reaction time Sensory evaluation Sensory integration Sensory testing Spinal cord injuries |
| title | Multimodal sensory evaluation of neuropathic spinal cord injury pain: an experimental study |
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