miRNA-146a Mimic Inhibits NOX4/P38 Signalling to Ameliorate Mouse Myocardial Ischaemia Reperfusion (I/R) Injury

Evidence suggests that miR-146a is implicated in the pathogenesis of cardiovascular diseases; however, the role of miR-146a in myocardial ischaemia reperfusion (I/R) injury is unclear. The aim of this study was to explore the functional role of miR-146a in myocardial ischaemia reperfusion injury and...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.6366254-6366254
Hauptverfasser:	Xiao, Lili, Gu, Yulei, Ren, Gaofei, Chen, Linlin, Liu, Liming, Wang, Xiaofang, Gao, Lu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cardiomyocytes Gene expression Gene Expression Regulation Heart attacks Inflammation - etiology Inflammation - metabolism Inflammation - pathology Inflammation - prevention & control Ischemia Laboratory animals Male Mice Mice, Inbred C57BL MicroRNAs - administration & dosage MicroRNAs - genetics Myocardial Reperfusion Injury - etiology Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - prevention & control Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology NADPH Oxidase 4 - genetics NADPH Oxidase 4 - metabolism Oxidative Stress Proteins Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Signal Transduction
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