Human endothelial colony-forming cells provide trophic support for pluripotent stem cell-derived cardiomyocytes via distinctively high expression of neuregulin-1

The search for a source of endothelial cells (ECs) with translational therapeutic potential remains crucial in regenerative medicine. Human blood-derived endothelial colony-forming cells (ECFCs) represent a promising source of autologous ECs due to their robust capacity to form vascular networks in...

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Veröffentlicht in:	Angiogenesis (London) 2021-05, Vol.24 (2), p.327-344
Hauptverfasser:	Hong, Xuechong, Oh, Nicholas, Wang, Kai, Neumeyer, Joseph, Lee, Chin Nien, Lin, Ruei-Zeng, Piekarski, Breanna, Emani, Sitaram, Greene, Arin K., Friehs, Ingeborg, del Nido, Pedro J., Melero-Martin, Juan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Apoptosis Autografts Biomedical and Life Sciences Biomedicine Blood vessels Cancer Research Cardiology Cardiomyocytes Cell Biology Cell Differentiation Cells, Cultured Colonies Colony-forming cells Endothelial cells Endothelial Progenitor Cells - metabolism Engraftment Gene Expression Regulation Gene silencing Growth factors Heart Humans Medicine Myocytes, Cardiac - metabolism Neuregulin Neuregulin 1 Neuregulin-1 - biosynthesis Oncology Ophthalmology Original Paper Paracrine Communication Paracrine signalling Peripheral blood Pluripotency Pluripotent Stem Cells - metabolism Progenitor cells Regenerative medicine Robustness Signal transduction Stem cells Translation
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