Inhibition of AMPA receptors (AMPARs) containing transmembrane AMPAR regulatory protein γ‐8 with JNJ‐55511118 shows preclinical efficacy in reducing chronic repetitive alcohol self‐administration

Background A prominent therapeutic indication for alcohol use disorder (AUD) is reduction in chronic repetitive alcohol use. Glutamate α‐Amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid (AMPA) receptors (AMPARs) regulate chronic alcohol self‐administration in preclinical models. Recent evidence i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Alcoholism, clinical and experimental research clinical and experimental research, 2021-07, Vol.45 (7), p.1424-1435
Hauptverfasser:	Hoffman, Jessica L., Faccidomo, Sara, Saunders, Briana L., Taylor, Seth M., Kim, Michelle, Hodge, Clyde W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictions Alcohol Drinking - drug therapy alcohol self‐administration Alcohol use Alcoholism AMPA Animals behavior Benzimidazoles - pharmacology Calcium Channels - drug effects Calcium Channels - physiology Drinking behavior Ethanol - administration & dosage Female JNJ‐55511118 Male Mice Mice, Inbred C57BL Motor Activity - drug effects Operant conditioning Propionic acid Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - chemistry Sex Factors Sucrose Sucrose - administration & dosage TARP γ‐8 α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!