LncRNA MAYA promotes iron overload and hepatocyte senescence through inhibition of YAP in non‐alcoholic fatty liver disease

Although recent evidence has shown that hepatocyte senescence plays a crucial role in the pathogenesis and development of non‐alcoholic fatty liver disease (NAFLD), the mechanism is still not clear. The purpose of this study was to investigate the signal transduction pathways involved in the senesce...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2021-08, Vol.25 (15), p.7354-7366
Hauptverfasser:	Yuan, Ping, Qi, Xiaoyu, Song, Anping, Ma, Mingyue, Zhang, Xinbei, Lu, Chunfeng, Bian, Mianli, Lian, Naqi, He, Jianling, Zheng, Shuguo, Jin, Huanhuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell cycle Cell Line Cellular Senescence Cricetinae DNA Damage Experiments Fatty liver Hepatocytes Hepatocytes - metabolism Hepatocytes - physiology Heterochromatin Humans Iron Iron - metabolism iron overload Laboratory animals Liver diseases MAYA Mesocricetus Metabolism Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - metabolism non‐alcoholic fatty liver disease Original Pathogenesis Polymerase chain reaction Reagents RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Senescence Signal transduction Telomerase YAP-Signaling Proteins - genetics YAP-Signaling Proteins - metabolism Yes-associated protein
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