Chitosan/Gold Hybrid Nanoparticles Enriched Electrospun PVA Nanofibrous Mats for the Topical Delivery of Punica granatum L. Extract: Synthesis, Characterization, Biocompatibility and Antibacterial Properties
Purpose: Intending to obtain Punica granatum L. extract (PE)-loaded drug delivery system of better impact and biomedical applicability, the current study reports the use of cross-linked PVA nanofibers (NFs) as platforms incorporating different amounts of biosynthesized PE-CS-gold nanoparticles (PE-C...
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| Veröffentlicht in: | International journal of nanomedicine 2021-01, Vol.16, p.5133-5151 |
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| container_title | International journal of nanomedicine |
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| creator | Hussein, Mohamed Ahmed Mohamady Ulag, Songul Dena, Ahmed S. Abo Sahin, Ali Grinholc, Mariusz Gunduz, Oguzhan Sherbiny, Ibrahim El Megahed, Mosaad |
| description | Purpose: Intending to obtain Punica granatum L. extract (PE)-loaded drug delivery system of better impact and biomedical applicability, the current study reports the use of cross-linked PVA nanofibers (NFs) as platforms incorporating different amounts of biosynthesized PE-CS-gold nanoparticles (PE-CS-Au NPs). Methods: PE-conjugated CS-Au nanoparticles (PE-CS-Au NPs) were synthesized via green chemistry approach. The formation of PE-CS-Au NPs was confirmed by UV spectroscopy, DLS, SEM and STEM. PE-CS-Au NPs were then dispersed into polyvinyl alcohol (PVA) solution at different ratios, where the optimized ratios were selected for electrospinning and further studies. Crosslinking of PE-CS-Au NPs loaded PVA nanofibers (NFs) was performed via glutaraldehyde vapor. The morphology, chemical compositions, thermal stability and mechanical properties of PE-CS-Au NPs loaded NFs were evaluated by SEM, FTIR and DSC. Swelling capacity, biodegradability, PE release profiles, release kinetics, antibacterial and cell biocompatibility were also demonstrated. Results: By incorporating PE-CS-Au NPs at 0.6% and 0.9%, the diameters of the nanofibers decreased from 295.7 [+ or -] 83.1 nm in neat PVA to 165.6 [+ or -] 43.4 and 147.8 [+ or -] 42.7 nm, respectively. It is worth noting that crosslinking and incorporation of PE-CS-Au NPs improved thermal stability and mechanical properties of the obtained NFs. The release of PE from NFs was controlled by a Fickian diffusion mechanism (n value |
| doi_str_mv | 10.2147/IJN.S306526 |
| format | Article |
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Extract: Synthesis, Characterization, Biocompatibility and Antibacterial Properties</title><source>Taylor & Francis Open Access</source><source>DOVE Medical Press Journals</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Hussein, Mohamed Ahmed Mohamady ; Ulag, Songul ; Dena, Ahmed S. Abo ; Sahin, Ali ; Grinholc, Mariusz ; Gunduz, Oguzhan ; Sherbiny, Ibrahim El ; Megahed, Mosaad</creator><creatorcontrib>Hussein, Mohamed Ahmed Mohamady ; Ulag, Songul ; Dena, Ahmed S. Abo ; Sahin, Ali ; Grinholc, Mariusz ; Gunduz, Oguzhan ; Sherbiny, Ibrahim El ; Megahed, Mosaad</creatorcontrib><description>Purpose: Intending to obtain Punica granatum L. extract (PE)-loaded drug delivery system of better impact and biomedical applicability, the current study reports the use of cross-linked PVA nanofibers (NFs) as platforms incorporating different amounts of biosynthesized PE-CS-gold nanoparticles (PE-CS-Au NPs). Methods: PE-conjugated CS-Au nanoparticles (PE-CS-Au NPs) were synthesized via green chemistry approach. The formation of PE-CS-Au NPs was confirmed by UV spectroscopy, DLS, SEM and STEM. PE-CS-Au NPs were then dispersed into polyvinyl alcohol (PVA) solution at different ratios, where the optimized ratios were selected for electrospinning and further studies. Crosslinking of PE-CS-Au NPs loaded PVA nanofibers (NFs) was performed via glutaraldehyde vapor. The morphology, chemical compositions, thermal stability and mechanical properties of PE-CS-Au NPs loaded NFs were evaluated by SEM, FTIR and DSC. Swelling capacity, biodegradability, PE release profiles, release kinetics, antibacterial and cell biocompatibility were also demonstrated. Results: By incorporating PE-CS-Au NPs at 0.6% and 0.9%, the diameters of the nanofibers decreased from 295.7 [+ or -] 83.1 nm in neat PVA to 165.6 [+ or -] 43.4 and 147.8 [+ or -] 42.7 nm, respectively. It is worth noting that crosslinking and incorporation of PE-CS-Au NPs improved thermal stability and mechanical properties of the obtained NFs. The release of PE from NFs was controlled by a Fickian diffusion mechanism (n value <0.5), whereas Higuchi was the mathematical model which could describe this release. The antibacterial activity was found to be directly proportional to the amount of the incorporated PE-CS-Au NPs. The human fibroblasts (HFF-1) showed the highest viability (123%) by seeding over the PVA NFs mats containing 0.9% PE-CS-Au NPs. Conclusion: The obtained results suggest that the electrospun PVA NFs composites containing 0.9% PE-CS-Au NPs can be used as antibacterial agents against antibiotic-resistant bacteria, and as suitable scaffolds for cell adhesion, growth and proliferation of fibroblast populations. Keywords: gold nanoparticles, chitosan, Punica granatum, nanofiber, antibacterial</description><identifier>ISSN: 1178-2013</identifier><identifier>ISSN: 1176-9114</identifier><identifier>EISSN: 1178-2013</identifier><identifier>DOI: 10.2147/IJN.S306526</identifier><identifier>PMID: 34354349</identifier><language>eng</language><publisher>Macclesfield: Dove Medical Press Limited</publisher><subject>Ablation ; Acids ; Analysis ; Antibiotics ; Biocompatibility ; Cell growth ; Crosslinked polymers ; Diabetes ; Drug delivery systems ; Drug resistance ; Enzymes ; Fibroblasts ; Fruits ; Green chemistry ; Methicillin ; Nanoparticles ; Original Research ; Polyvinyl alcohol ; Spectrum analysis ; Staphylococcus infections ; Transdermal medication ; Wound healing</subject><ispartof>International journal of nanomedicine, 2021-01, Vol.16, p.5133-5151</ispartof><rights>COPYRIGHT 2021 Dove Medical Press Limited</rights><rights>2021. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Mohamady Hussein et al. 2021 Mohamady Hussein et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-afb68f1bb558998d061287327470423ae738c1d9d3953acb50cd94439aba32f73</citedby><cites>FETCH-LOGICAL-c453t-afb68f1bb558998d061287327470423ae738c1d9d3953acb50cd94439aba32f73</cites><orcidid>0000-0001-5594-1551 ; 0000-0003-3555-804X ; 0000-0001-9624-4656 ; 0000-0002-8179-437X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331124/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331124/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,3849,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Hussein, Mohamed Ahmed Mohamady</creatorcontrib><creatorcontrib>Ulag, Songul</creatorcontrib><creatorcontrib>Dena, Ahmed S. Abo</creatorcontrib><creatorcontrib>Sahin, Ali</creatorcontrib><creatorcontrib>Grinholc, Mariusz</creatorcontrib><creatorcontrib>Gunduz, Oguzhan</creatorcontrib><creatorcontrib>Sherbiny, Ibrahim El</creatorcontrib><creatorcontrib>Megahed, Mosaad</creatorcontrib><title>Chitosan/Gold Hybrid Nanoparticles Enriched Electrospun PVA Nanofibrous Mats for the Topical Delivery of Punica granatum L. Extract: Synthesis, Characterization, Biocompatibility and Antibacterial Properties</title><title>International journal of nanomedicine</title><description>Purpose: Intending to obtain Punica granatum L. extract (PE)-loaded drug delivery system of better impact and biomedical applicability, the current study reports the use of cross-linked PVA nanofibers (NFs) as platforms incorporating different amounts of biosynthesized PE-CS-gold nanoparticles (PE-CS-Au NPs). Methods: PE-conjugated CS-Au nanoparticles (PE-CS-Au NPs) were synthesized via green chemistry approach. The formation of PE-CS-Au NPs was confirmed by UV spectroscopy, DLS, SEM and STEM. PE-CS-Au NPs were then dispersed into polyvinyl alcohol (PVA) solution at different ratios, where the optimized ratios were selected for electrospinning and further studies. Crosslinking of PE-CS-Au NPs loaded PVA nanofibers (NFs) was performed via glutaraldehyde vapor. The morphology, chemical compositions, thermal stability and mechanical properties of PE-CS-Au NPs loaded NFs were evaluated by SEM, FTIR and DSC. Swelling capacity, biodegradability, PE release profiles, release kinetics, antibacterial and cell biocompatibility were also demonstrated. Results: By incorporating PE-CS-Au NPs at 0.6% and 0.9%, the diameters of the nanofibers decreased from 295.7 [+ or -] 83.1 nm in neat PVA to 165.6 [+ or -] 43.4 and 147.8 [+ or -] 42.7 nm, respectively. It is worth noting that crosslinking and incorporation of PE-CS-Au NPs improved thermal stability and mechanical properties of the obtained NFs. The release of PE from NFs was controlled by a Fickian diffusion mechanism (n value <0.5), whereas Higuchi was the mathematical model which could describe this release. The antibacterial activity was found to be directly proportional to the amount of the incorporated PE-CS-Au NPs. The human fibroblasts (HFF-1) showed the highest viability (123%) by seeding over the PVA NFs mats containing 0.9% PE-CS-Au NPs. Conclusion: The obtained results suggest that the electrospun PVA NFs composites containing 0.9% PE-CS-Au NPs can be used as antibacterial agents against antibiotic-resistant bacteria, and as suitable scaffolds for cell adhesion, growth and proliferation of fibroblast populations. Keywords: gold nanoparticles, chitosan, Punica granatum, nanofiber, antibacterial</description><subject>Ablation</subject><subject>Acids</subject><subject>Analysis</subject><subject>Antibiotics</subject><subject>Biocompatibility</subject><subject>Cell growth</subject><subject>Crosslinked polymers</subject><subject>Diabetes</subject><subject>Drug delivery systems</subject><subject>Drug resistance</subject><subject>Enzymes</subject><subject>Fibroblasts</subject><subject>Fruits</subject><subject>Green chemistry</subject><subject>Methicillin</subject><subject>Nanoparticles</subject><subject>Original Research</subject><subject>Polyvinyl alcohol</subject><subject>Spectrum analysis</subject><subject>Staphylococcus infections</subject><subject>Transdermal medication</subject><subject>Wound healing</subject><issn>1178-2013</issn><issn>1176-9114</issn><issn>1178-2013</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptks1u1DAQxyMEoqVw4gUscUGiu42_4oQD0rIsbdFSVmrhajmOs-vKsYPtVISX5JVw2BVQhHywZ_yb_3jGk2XPYT5HkLCzyw9X82ucFxQVD7JjCFk5QznED_86H2VPQrjNc8rKonqcHWGCKcGkOs5-LHc6uiDs2bkzDbgYa68bcCWs64WPWhoVwMp6LXeqASujZPQu9IMFmy-LX1ira--GAD6KGEDrPIg7BW5cr6Uw4J0y-k75EbgWbAabfGDrhRVx6MB6DlbfohcyvgbXo01hQYdTsNyJyae8_i6idvYUvNVOuq5PVq2NjiMQtgELm8w9l_JsvOtVeq4KT7NHrTBBPTvsJ9nn96ub5cVs_en8crlYzyShOM5EWxdlC-ua0rKqyiYvICoZRoywnCAsFMOlhE3V4IpiIWuay6YiBFeiFhi1DJ9kb_a6_VB3qpHKplIM773uhB-5E5rfv7F6x7fujpcYQ4hIEnh5EPDu66BC5J0OUhkjrEr95IjSiiDKiinXi3_QWzd4m8pLVIHy9JEY_qG2wiiubeum5k6ifFEwVBBWIpqo-X-otBrVaemsanXy3wt4tQ-Q6eODV-3vGmHOp_njaf74Yf7wT6iYzuw</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Hussein, Mohamed Ahmed Mohamady</creator><creator>Ulag, Songul</creator><creator>Dena, Ahmed S. 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Extract: Synthesis, Characterization, Biocompatibility and Antibacterial Properties</title><author>Hussein, Mohamed Ahmed Mohamady ; Ulag, Songul ; Dena, Ahmed S. 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Abo</au><au>Sahin, Ali</au><au>Grinholc, Mariusz</au><au>Gunduz, Oguzhan</au><au>Sherbiny, Ibrahim El</au><au>Megahed, Mosaad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chitosan/Gold Hybrid Nanoparticles Enriched Electrospun PVA Nanofibrous Mats for the Topical Delivery of Punica granatum L. Extract: Synthesis, Characterization, Biocompatibility and Antibacterial Properties</atitle><jtitle>International journal of nanomedicine</jtitle><date>2021-01-01</date><risdate>2021</risdate><volume>16</volume><spage>5133</spage><epage>5151</epage><pages>5133-5151</pages><issn>1178-2013</issn><issn>1176-9114</issn><eissn>1178-2013</eissn><abstract>Purpose: Intending to obtain Punica granatum L. extract (PE)-loaded drug delivery system of better impact and biomedical applicability, the current study reports the use of cross-linked PVA nanofibers (NFs) as platforms incorporating different amounts of biosynthesized PE-CS-gold nanoparticles (PE-CS-Au NPs). Methods: PE-conjugated CS-Au nanoparticles (PE-CS-Au NPs) were synthesized via green chemistry approach. The formation of PE-CS-Au NPs was confirmed by UV spectroscopy, DLS, SEM and STEM. PE-CS-Au NPs were then dispersed into polyvinyl alcohol (PVA) solution at different ratios, where the optimized ratios were selected for electrospinning and further studies. Crosslinking of PE-CS-Au NPs loaded PVA nanofibers (NFs) was performed via glutaraldehyde vapor. The morphology, chemical compositions, thermal stability and mechanical properties of PE-CS-Au NPs loaded NFs were evaluated by SEM, FTIR and DSC. Swelling capacity, biodegradability, PE release profiles, release kinetics, antibacterial and cell biocompatibility were also demonstrated. Results: By incorporating PE-CS-Au NPs at 0.6% and 0.9%, the diameters of the nanofibers decreased from 295.7 [+ or -] 83.1 nm in neat PVA to 165.6 [+ or -] 43.4 and 147.8 [+ or -] 42.7 nm, respectively. It is worth noting that crosslinking and incorporation of PE-CS-Au NPs improved thermal stability and mechanical properties of the obtained NFs. The release of PE from NFs was controlled by a Fickian diffusion mechanism (n value <0.5), whereas Higuchi was the mathematical model which could describe this release. The antibacterial activity was found to be directly proportional to the amount of the incorporated PE-CS-Au NPs. The human fibroblasts (HFF-1) showed the highest viability (123%) by seeding over the PVA NFs mats containing 0.9% PE-CS-Au NPs. Conclusion: The obtained results suggest that the electrospun PVA NFs composites containing 0.9% PE-CS-Au NPs can be used as antibacterial agents against antibiotic-resistant bacteria, and as suitable scaffolds for cell adhesion, growth and proliferation of fibroblast populations. Keywords: gold nanoparticles, chitosan, Punica granatum, nanofiber, antibacterial</abstract><cop>Macclesfield</cop><pub>Dove Medical Press Limited</pub><pmid>34354349</pmid><doi>10.2147/IJN.S306526</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0001-5594-1551</orcidid><orcidid>https://orcid.org/0000-0003-3555-804X</orcidid><orcidid>https://orcid.org/0000-0001-9624-4656</orcidid><orcidid>https://orcid.org/0000-0002-8179-437X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Taylor & Francis Open Access; DOVE Medical Press Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Ablation Acids Analysis Antibiotics Biocompatibility Cell growth Crosslinked polymers Diabetes Drug delivery systems Drug resistance Enzymes Fibroblasts Fruits Green chemistry Methicillin Nanoparticles Original Research Polyvinyl alcohol Spectrum analysis Staphylococcus infections Transdermal medication Wound healing |
| title | Chitosan/Gold Hybrid Nanoparticles Enriched Electrospun PVA Nanofibrous Mats for the Topical Delivery of Punica granatum L. Extract: Synthesis, Characterization, Biocompatibility and Antibacterial Properties |
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