The Clinical Significance of Serum IL-33 and sST2 Alterations in the Post-Stroke Depression
Introduction: This study was to test whether the serum levels of IL-33 and sST2 are correlated with the development of depression after acute ischemic stroke. Methods: Patients diagnosed with acute ischemic stroke were selected. This study took the 24-item Hamilton Depression Rating Scale (HAMD) (sc...
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| Veröffentlicht in: | Journal of multidisciplinary healthcare 2021-01, Vol.14, p.2009-2015 |
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| description | Introduction: This study was to test whether the serum levels of IL-33 and sST2 are correlated with the development of depression after acute ischemic stroke.
Methods: Patients diagnosed with acute ischemic stroke were selected. This study took the 24-item Hamilton Depression Rating Scale (HAMD) (score >= 20) as the diagnostic criteria for depression. On the 21st day after admission, patients who met the depression diagnostic criteria were included in the depression group, and patients who failed to meet the diagnostic criteria were included in the non-depression group. The serum levels of IL-33, sST2 and hsCRP were measured by enzyme-linked immunosorbent assay (ELISA).
Results: On 1st day after stroke, compared with the non-depression group, there was no significant difference in the serum IL-33, sST2 and hsCRP levels in the depression group; on 21st day after stroke, compared with the non-depression group, the serum IL-33 and hsCRP levels were significantly increased, while the sST2 level was significantly decreased in the depression group. Correlation analysis showed that IL-33 was positively correlated with the depression quantitative score and hsCRP, while sST2 was negatively correlated with the depression quantitative score and hsCRP. Regression analysis showed that IL-33 and sST2 were independent risk factors for the depression after acute ischemic stroke.
Discussion: The abnormal alterations of serum IL-33 and sST2 levels in the stroke patients may serve as one of the risk factors for the occurrence and exacerbation of the depression, and its mechanism may be related to the promotion of inflammatory factor production in vivo. |
| doi_str_mv | 10.2147/JMDH.S310524 |
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Methods: Patients diagnosed with acute ischemic stroke were selected. This study took the 24-item Hamilton Depression Rating Scale (HAMD) (score >= 20) as the diagnostic criteria for depression. On the 21st day after admission, patients who met the depression diagnostic criteria were included in the depression group, and patients who failed to meet the diagnostic criteria were included in the non-depression group. The serum levels of IL-33, sST2 and hsCRP were measured by enzyme-linked immunosorbent assay (ELISA).
Results: On 1st day after stroke, compared with the non-depression group, there was no significant difference in the serum IL-33, sST2 and hsCRP levels in the depression group; on 21st day after stroke, compared with the non-depression group, the serum IL-33 and hsCRP levels were significantly increased, while the sST2 level was significantly decreased in the depression group. Correlation analysis showed that IL-33 was positively correlated with the depression quantitative score and hsCRP, while sST2 was negatively correlated with the depression quantitative score and hsCRP. Regression analysis showed that IL-33 and sST2 were independent risk factors for the depression after acute ischemic stroke.
Discussion: The abnormal alterations of serum IL-33 and sST2 levels in the stroke patients may serve as one of the risk factors for the occurrence and exacerbation of the depression, and its mechanism may be related to the promotion of inflammatory factor production in vivo.</description><identifier>ISSN: 1178-2390</identifier><identifier>EISSN: 1178-2390</identifier><identifier>DOI: 10.2147/JMDH.S310524</identifier><identifier>PMID: 34354360</identifier><language>eng</language><publisher>ALBANY: Dove Medical Press Ltd</publisher><subject>Blood pressure ; Clinical significance ; Correlation analysis ; Cytokines ; Depression, Mental ; Enzyme-linked immunosorbent assay ; Enzymes ; Health aspects ; Health Care Sciences & Services ; il-33 ; Ischemia ; Life Sciences & Biomedicine ; Mental depression ; Mental disorders ; Nervous system ; Neurological disorders ; Original Research ; Pathogenesis ; post-stroke depression (psd) ; Regression analysis ; risk factor ; Risk factors ; Science & Technology ; sst2 ; Statistical analysis ; Stroke ; Stroke (Disease)</subject><ispartof>Journal of multidisciplinary healthcare, 2021-01, Vol.14, p.2009-2015</ispartof><rights>COPYRIGHT 2021 Dove Medical Press Limited</rights><rights>2021. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Xu and Wu. 2021 Xu and Wu.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>11</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000680384000001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c553t-47246d24e877312bfb0e7e84ec7c5e0129c9dc02586777a626c351f602f657263</citedby><cites>FETCH-LOGICAL-c553t-47246d24e877312bfb0e7e84ec7c5e0129c9dc02586777a626c351f602f657263</cites><orcidid>0000-0003-1953-4996</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331084/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331084/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,3863,27929,27930,39263,53796,53798</link.rule.ids></links><search><creatorcontrib>Xu, Meirong</creatorcontrib><creatorcontrib>Wu, Ganlin</creatorcontrib><title>The Clinical Significance of Serum IL-33 and sST2 Alterations in the Post-Stroke Depression</title><title>Journal of multidisciplinary healthcare</title><addtitle>J MULTIDISCIP HEALTH</addtitle><description>Introduction: This study was to test whether the serum levels of IL-33 and sST2 are correlated with the development of depression after acute ischemic stroke.
Methods: Patients diagnosed with acute ischemic stroke were selected. This study took the 24-item Hamilton Depression Rating Scale (HAMD) (score >= 20) as the diagnostic criteria for depression. On the 21st day after admission, patients who met the depression diagnostic criteria were included in the depression group, and patients who failed to meet the diagnostic criteria were included in the non-depression group. The serum levels of IL-33, sST2 and hsCRP were measured by enzyme-linked immunosorbent assay (ELISA).
Results: On 1st day after stroke, compared with the non-depression group, there was no significant difference in the serum IL-33, sST2 and hsCRP levels in the depression group; on 21st day after stroke, compared with the non-depression group, the serum IL-33 and hsCRP levels were significantly increased, while the sST2 level was significantly decreased in the depression group. Correlation analysis showed that IL-33 was positively correlated with the depression quantitative score and hsCRP, while sST2 was negatively correlated with the depression quantitative score and hsCRP. Regression analysis showed that IL-33 and sST2 were independent risk factors for the depression after acute ischemic stroke.
Discussion: The abnormal alterations of serum IL-33 and sST2 levels in the stroke patients may serve as one of the risk factors for the occurrence and exacerbation of the depression, and its mechanism may be related to the promotion of inflammatory factor production in vivo.</description><subject>Blood pressure</subject><subject>Clinical significance</subject><subject>Correlation analysis</subject><subject>Cytokines</subject><subject>Depression, Mental</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzymes</subject><subject>Health aspects</subject><subject>Health Care Sciences & Services</subject><subject>il-33</subject><subject>Ischemia</subject><subject>Life Sciences & Biomedicine</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Nervous system</subject><subject>Neurological disorders</subject><subject>Original Research</subject><subject>Pathogenesis</subject><subject>post-stroke depression (psd)</subject><subject>Regression analysis</subject><subject>risk factor</subject><subject>Risk factors</subject><subject>Science & Technology</subject><subject>sst2</subject><subject>Statistical analysis</subject><subject>Stroke</subject><subject>Stroke (Disease)</subject><issn>1178-2390</issn><issn>1178-2390</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2LEzEYhQdR3HX1zh8wIIigUzP5nhuhdNWtVBRar7wImfSdNnWa1CSj-O9NP1i34oUJJCF5znlJcoriaY1GuKbi9YeP1zejOakRw_RecVnXQlaYNOj-nfVF8SjGDUJcYikeFheEEkYJR5fF18UayklvnTW6L-d25WyXl85A6btyDmHYltNZRUip3bKM8wUux32CoJP1LpbWlSkbfPYxVfMU_Dcor2EXIMZ8_Lh40Ok-wpPTfFV8efd2MbmpZp_eTyfjWWUYI6miAlO-xBSkEKTGbdciECApGGEYoBo3plkahJnkQgjNMTeE1R1HuONMYE6uiunRd-n1Ru2C3erwS3lt1WHDh5XSIVnTgzJGkLYhrcwDFZQ1rWk4FrjRqJOE4ez15ui1G9otLA24FHR_Znp-4uxarfwPJUn-AkmzwYuTQfDfB4hJbW000PfagR-iwow1FNOGyow--wvd-CG4_FSZ4hiRhtXNH2ql8wWs63yua_amaszz9angh7Kjf1C5L2FrjXfQ2bx_Jnh-R7AG3ad19P1w-Ndz8NURNMHHGKC7fYwaqX0C1T6B6pTAjMsj_hNa30VjIWfpVoL2GUREUrRv9cSmQ5AmfnApS1_-v5T8BqQ354w</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Xu, Meirong</creator><creator>Wu, Ganlin</creator><general>Dove Medical Press Ltd</general><general>Dove Medical Press Limited</general><general>Taylor & Francis Ltd</general><general>Dove</general><general>Dove Medical Press</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7XB</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>KB0</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-1953-4996</orcidid></search><sort><creationdate>20210101</creationdate><title>The Clinical Significance of Serum IL-33 and sST2 Alterations in the Post-Stroke Depression</title><author>Xu, Meirong ; Wu, Ganlin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c553t-47246d24e877312bfb0e7e84ec7c5e0129c9dc02586777a626c351f602f657263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Blood pressure</topic><topic>Clinical significance</topic><topic>Correlation analysis</topic><topic>Cytokines</topic><topic>Depression, Mental</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Enzymes</topic><topic>Health aspects</topic><topic>Health Care Sciences & Services</topic><topic>il-33</topic><topic>Ischemia</topic><topic>Life Sciences & Biomedicine</topic><topic>Mental depression</topic><topic>Mental disorders</topic><topic>Nervous system</topic><topic>Neurological disorders</topic><topic>Original Research</topic><topic>Pathogenesis</topic><topic>post-stroke depression (psd)</topic><topic>Regression analysis</topic><topic>risk factor</topic><topic>Risk factors</topic><topic>Science & Technology</topic><topic>sst2</topic><topic>Statistical analysis</topic><topic>Stroke</topic><topic>Stroke (Disease)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Meirong</creatorcontrib><creatorcontrib>Wu, Ganlin</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of multidisciplinary healthcare</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Meirong</au><au>Wu, Ganlin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Clinical Significance of Serum IL-33 and sST2 Alterations in the Post-Stroke Depression</atitle><jtitle>Journal of multidisciplinary healthcare</jtitle><stitle>J MULTIDISCIP HEALTH</stitle><date>2021-01-01</date><risdate>2021</risdate><volume>14</volume><spage>2009</spage><epage>2015</epage><pages>2009-2015</pages><issn>1178-2390</issn><eissn>1178-2390</eissn><abstract>Introduction: This study was to test whether the serum levels of IL-33 and sST2 are correlated with the development of depression after acute ischemic stroke.
Methods: Patients diagnosed with acute ischemic stroke were selected. This study took the 24-item Hamilton Depression Rating Scale (HAMD) (score >= 20) as the diagnostic criteria for depression. On the 21st day after admission, patients who met the depression diagnostic criteria were included in the depression group, and patients who failed to meet the diagnostic criteria were included in the non-depression group. The serum levels of IL-33, sST2 and hsCRP were measured by enzyme-linked immunosorbent assay (ELISA).
Results: On 1st day after stroke, compared with the non-depression group, there was no significant difference in the serum IL-33, sST2 and hsCRP levels in the depression group; on 21st day after stroke, compared with the non-depression group, the serum IL-33 and hsCRP levels were significantly increased, while the sST2 level was significantly decreased in the depression group. Correlation analysis showed that IL-33 was positively correlated with the depression quantitative score and hsCRP, while sST2 was negatively correlated with the depression quantitative score and hsCRP. Regression analysis showed that IL-33 and sST2 were independent risk factors for the depression after acute ischemic stroke.
Discussion: The abnormal alterations of serum IL-33 and sST2 levels in the stroke patients may serve as one of the risk factors for the occurrence and exacerbation of the depression, and its mechanism may be related to the promotion of inflammatory factor production in vivo.</abstract><cop>ALBANY</cop><pub>Dove Medical Press Ltd</pub><pmid>34354360</pmid><doi>10.2147/JMDH.S310524</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1953-4996</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Blood pressure Clinical significance Correlation analysis Cytokines Depression, Mental Enzyme-linked immunosorbent assay Enzymes Health aspects Health Care Sciences & Services il-33 Ischemia Life Sciences & Biomedicine Mental depression Mental disorders Nervous system Neurological disorders Original Research Pathogenesis post-stroke depression (psd) Regression analysis risk factor Risk factors Science & Technology sst2 Statistical analysis Stroke Stroke (Disease) |
| title | The Clinical Significance of Serum IL-33 and sST2 Alterations in the Post-Stroke Depression |
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