The PfAP2‐G2 transcription factor is a critical regulator of gametocyte maturation

Differentiation from asexual blood stages to mature sexual gametocytes is required for the transmission of malaria parasites. Here, we report that the ApiAP2 transcription factor, PfAP2‐G2 (PF3D7_1408200) plays a critical role in the maturation of Plasmodium falciparum gametocytes. PfAP2‐G2 binds to...

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Veröffentlicht in:	Molecular microbiology 2021-05, Vol.115 (5), p.1005-1024
Hauptverfasser:	Singh, Suprita, Santos, Joana M., Orchard, Lindsey M., Yamada, Naomi, Biljon, Riëtte, Painter, Heather J., Mahony, Shaun, Llinás, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	ApiAP2 Asexuality Chromatin remodeling Disease transmission gametocyte Gametocytes Gametogenesis Gene Expression Regulation, Developmental Genes Germ Cells - growth & development Germ Cells - metabolism Heterochromatin Heterochromatin protein 1 Histones Humans Life Cycle Stages Life cycles Malaria Malaria, Falciparum - parasitology Maturation Occupancy Parasites PfAP2‐G2 Plasmodium falciparum Plasmodium falciparum - genetics Plasmodium falciparum - growth & development Plasmodium falciparum - metabolism Proteins Protozoan Proteins - genetics Protozoan Proteins - metabolism Regulatory mechanisms (biology) Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Vector-borne diseases
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