The Short-Term Effect of Eugenol on the Prevention of Experimentally Induced Myringosclerosis in a Rat Model
Objective:The aim of our study was to assess the possible short-term effects of topical and oral eugenol on the suppression of experimentally developed myringosclerosis (MS).Methods:Four groups of seven male Wistar albino rats were used in the study. The tympanic membranes (TMs) of all subjects were...
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| Veröffentlicht in: | Turkish Archives of Otorhinolaryngology 2021-06, Vol.59 (2), p.124-132 |
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| container_title | Turkish Archives of Otorhinolaryngology |
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| creator | Eğilmez, Oğuz Kadir Güven, Mehmet Genç Elden, Sena Budak, Özcan Çakıroğlu, Hüseyin Elden, Halil Güven, Ebru Mihriban |
| description | Objective:The aim of our study was to assess the possible short-term effects of topical and oral eugenol on the suppression of experimentally developed myringosclerosis (MS).Methods:Four groups of seven male Wistar albino rats were used in the study. The tympanic membranes (TMs) of all subjects were myringotomized, and group 1 was given no treatment (as control group), group 2 received saline, group 3 had received topical eugenol and group 4 received oral eugenol.Results:In macroscopic evaluation the control and saline groups showed much more MS compared to the topical and oral eugenol groups which had statistically significantly less changes (p |
| doi_str_mv | 10.4274/tao.2021.6196 |
| format | Article |
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The tympanic membranes (TMs) of all subjects were myringotomized, and group 1 was given no treatment (as control group), group 2 received saline, group 3 had received topical eugenol and group 4 received oral eugenol.Results:In macroscopic evaluation the control and saline groups showed much more MS compared to the topical and oral eugenol groups which had statistically significantly less changes (p<0.05). Fibrosis and inflammation regarding the lamina propria (LP) of the eardrums of the topical and oral eugenol groups were significantly less than those of the control and saline groups (p<0.001). In microscopic evaluation, TMs were found to be thicker in the control and saline groups (p<0.001).Conclusion:Our study showed that the application of topical and oral forms of eugenol reduced fibrosis and prevented the advancement of MS in the LP of the TMs in the short-term. More studies with different extracts are needed to investigate the efficacy of phytotherapeutic agents for preventing MS development following myringotomy.</description><identifier>ISSN: 0304-4793</identifier><identifier>ISSN: 2667-7466</identifier><identifier>ISSN: 2667-7474</identifier><identifier>EISSN: 1303-6289</identifier><identifier>EISSN: 2667-7474</identifier><identifier>DOI: 10.4274/tao.2021.6196</identifier><identifier>PMID: 34386799</identifier><language>eng</language><publisher>Galenos Publishing</publisher><subject>animal experimentation ; antioxidants ; eugenol ; myringosclerosis ; Original Investigation ; rats ; tympanic membrane</subject><ispartof>Turkish Archives of Otorhinolaryngology, 2021-06, Vol.59 (2), p.124-132</ispartof><rights>Copyright 2021 by Official Journal of the Turkish Society of Otorhinolaryngology and Head and Neck Surgery 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-c04ae2379c208ed0feb3914b30b3eee4eb8e6334495baa52d1e1ec6f91a67cf23</citedby><orcidid>0000-0001-9623-9152 ; 0000-0002-9743-2867 ; 0000-0002-6306-4357 ; 0000-0002-3479-1600 ; 0000-0002-3665-2428 ; 0000-0002-1285-0665 ; 0000-0002-3445-6060</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329402/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329402/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Eğilmez, Oğuz Kadir</creatorcontrib><creatorcontrib>Güven, Mehmet</creatorcontrib><creatorcontrib>Genç Elden, Sena</creatorcontrib><creatorcontrib>Budak, Özcan</creatorcontrib><creatorcontrib>Çakıroğlu, Hüseyin</creatorcontrib><creatorcontrib>Elden, Halil</creatorcontrib><creatorcontrib>Güven, Ebru Mihriban</creatorcontrib><title>The Short-Term Effect of Eugenol on the Prevention of Experimentally Induced Myringosclerosis in a Rat Model</title><title>Turkish Archives of Otorhinolaryngology</title><description>Objective:The aim of our study was to assess the possible short-term effects of topical and oral eugenol on the suppression of experimentally developed myringosclerosis (MS).Methods:Four groups of seven male Wistar albino rats were used in the study. The tympanic membranes (TMs) of all subjects were myringotomized, and group 1 was given no treatment (as control group), group 2 received saline, group 3 had received topical eugenol and group 4 received oral eugenol.Results:In macroscopic evaluation the control and saline groups showed much more MS compared to the topical and oral eugenol groups which had statistically significantly less changes (p<0.05). Fibrosis and inflammation regarding the lamina propria (LP) of the eardrums of the topical and oral eugenol groups were significantly less than those of the control and saline groups (p<0.001). In microscopic evaluation, TMs were found to be thicker in the control and saline groups (p<0.001).Conclusion:Our study showed that the application of topical and oral forms of eugenol reduced fibrosis and prevented the advancement of MS in the LP of the TMs in the short-term. More studies with different extracts are needed to investigate the efficacy of phytotherapeutic agents for preventing MS development following myringotomy.</description><subject>animal experimentation</subject><subject>antioxidants</subject><subject>eugenol</subject><subject>myringosclerosis</subject><subject>Original Investigation</subject><subject>rats</subject><subject>tympanic membrane</subject><issn>0304-4793</issn><issn>2667-7466</issn><issn>2667-7474</issn><issn>1303-6289</issn><issn>2667-7474</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkU1rGzEQhkVoaFynx9z1B9bR12qlS6EEtzE4tDTOWcxKs_aG9cpo16b-99XWpeDTMF8P78xLyANnCyUq9ThCXAgm-EJzq2_IjEsmCy2M_UBmTDJVqMrKO_JpGN4ZE5Yz85HcSSWNrqydkW6zQ_q6i2ksNpj2dNk06EcaG7o8brGPHY09HfPMz4Qn7Mc2p1Pz9wFTu88F6LozXfXh6DHQl3Nq-20cfIcpDu1A254C_QUjfYkBu3ty20A34Od_cU7evi03T8_F-sf31dPXdeHzSWPhmQIUsrJeMIOBNVhLy1UtWS0RUWFtUEuplC1rgFIEjhy9biwHXflGyDlZXbghwrs7ZKGQzi5C6_4WYto6SGObVToudP4FlEyLUgUDxoK2WHpWVSZAmFhfLqzDsd5j8PnkBN0V9LrTtzu3jSdnpLCKTYDiAvD5JUPC5v8uZ26y0GUL3WShmyyUfwCu8I-p</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Eğilmez, Oğuz Kadir</creator><creator>Güven, Mehmet</creator><creator>Genç Elden, Sena</creator><creator>Budak, Özcan</creator><creator>Çakıroğlu, Hüseyin</creator><creator>Elden, Halil</creator><creator>Güven, Ebru Mihriban</creator><general>Galenos Publishing</general><general>Galenos Yayincilik</general><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-9623-9152</orcidid><orcidid>https://orcid.org/0000-0002-9743-2867</orcidid><orcidid>https://orcid.org/0000-0002-6306-4357</orcidid><orcidid>https://orcid.org/0000-0002-3479-1600</orcidid><orcidid>https://orcid.org/0000-0002-3665-2428</orcidid><orcidid>https://orcid.org/0000-0002-1285-0665</orcidid><orcidid>https://orcid.org/0000-0002-3445-6060</orcidid></search><sort><creationdate>20210601</creationdate><title>The Short-Term Effect of Eugenol on the Prevention of Experimentally Induced Myringosclerosis in a Rat Model</title><author>Eğilmez, Oğuz Kadir ; Güven, Mehmet ; Genç Elden, Sena ; Budak, Özcan ; Çakıroğlu, Hüseyin ; Elden, Halil ; Güven, Ebru Mihriban</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-c04ae2379c208ed0feb3914b30b3eee4eb8e6334495baa52d1e1ec6f91a67cf23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>animal experimentation</topic><topic>antioxidants</topic><topic>eugenol</topic><topic>myringosclerosis</topic><topic>Original Investigation</topic><topic>rats</topic><topic>tympanic membrane</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eğilmez, Oğuz Kadir</creatorcontrib><creatorcontrib>Güven, Mehmet</creatorcontrib><creatorcontrib>Genç Elden, Sena</creatorcontrib><creatorcontrib>Budak, Özcan</creatorcontrib><creatorcontrib>Çakıroğlu, Hüseyin</creatorcontrib><creatorcontrib>Elden, Halil</creatorcontrib><creatorcontrib>Güven, Ebru Mihriban</creatorcontrib><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Turkish Archives of Otorhinolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eğilmez, Oğuz Kadir</au><au>Güven, Mehmet</au><au>Genç Elden, Sena</au><au>Budak, Özcan</au><au>Çakıroğlu, Hüseyin</au><au>Elden, Halil</au><au>Güven, Ebru Mihriban</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Short-Term Effect of Eugenol on the Prevention of Experimentally Induced Myringosclerosis in a Rat Model</atitle><jtitle>Turkish Archives of Otorhinolaryngology</jtitle><date>2021-06-01</date><risdate>2021</risdate><volume>59</volume><issue>2</issue><spage>124</spage><epage>132</epage><pages>124-132</pages><issn>0304-4793</issn><issn>2667-7466</issn><issn>2667-7474</issn><eissn>1303-6289</eissn><eissn>2667-7474</eissn><abstract>Objective:The aim of our study was to assess the possible short-term effects of topical and oral eugenol on the suppression of experimentally developed myringosclerosis (MS).Methods:Four groups of seven male Wistar albino rats were used in the study. 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| subjects | animal experimentation antioxidants eugenol myringosclerosis Original Investigation rats tympanic membrane |
| title | The Short-Term Effect of Eugenol on the Prevention of Experimentally Induced Myringosclerosis in a Rat Model |
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