Infectious Complications Predict Premature CD8+ T-cell Senescence in CD40 Ligand-Deficient Patients

Purpose CD40 ligand (CD40L)-deficient patients display increased susceptibilities to infections that can be mitigated with effective prophylactic strategies including immunoglobulin G (IgG) replacement and prophylactic antibiotics. CD8 + T-cell senescence has been described in CD40L deficiency, but...

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Veröffentlicht in:	Journal of clinical immunology 2021-05, Vol.41 (4), p.795-806
Hauptverfasser:	Shin, Junghee J., Catanzaro, Jason, Yonkof, Jennifer R., Delmonte, Ottavia, Sacco, Keith, Shin, Min Sun, Reddy, Srikar, Whittington, Paula J., Soffer, Gary, Mustillo, Peter J., Sullivan, Kathleen E., Notarangelo, Luigi D., Abraham, Roshini S., Romberg, Neil, Kang, Insoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age of Onset Antibiotics Biomarkers Biomedical and Life Sciences Biomedicine Case-Control Studies CD40 antigen CD40 Ligand - deficiency CD40L protein CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cellular Senescence - genetics Child, Preschool Children Cytokines Disease prevention Effector cells Flow cytometry Genes, X-Linked Genetic Association Studies - methods Genetic Predisposition to Disease Humans Immune System Diseases - complications Immune System Diseases - etiology Immunoglobulin G Immunoglobulins Immunological memory Immunology Immunophenotyping Infections Infections - diagnosis Infections - etiology Infectious Diseases Internal Medicine Ligands Lymphocytes T Medical Microbiology Memory cells Original Article Patients Pedigree Phenotype Phenotypes Prognosis Prophylaxis Receptors, Antigen, T-Cell Senescence T cell receptors Young Adult
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