RNA polymerase II speed: a key player in controlling and adapting transcriptome composition

RNA polymerase II (RNA Pol II) speed or elongation rate, i.e., the number of nucleotides synthesized per unit of time, is a major determinant of transcriptome composition. It controls co‐transcriptional processes such as splicing, polyadenylation, and transcription termination, thus regulating the p...

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Veröffentlicht in:	The EMBO journal 2021-08, Vol.40 (15), p.e105740-n/a
Hauptverfasser:	Muniz, Lisa, Nicolas, Estelle, Trouche, Didier
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Animals Biochemistry - methods Changing environments Chromatin - genetics Chromatin - metabolism Composition co‐transcriptional processes Deregulation DNA-directed RNA polymerase Elongation EMBO09 Environmental changes Gene Expression Histones - genetics Humans Life Sciences Molecular Imaging - methods Nucleotides Physiology Polyadenylation Review RNA Folding RNA modification RNA polymerase RNA polymerase II RNA Polymerase II - chemistry RNA Polymerase II - genetics RNA Polymerase II - metabolism RNA Processing, Post-Transcriptional RNA Splicing RNA, Messenger - genetics RNA, Messenger - metabolism Splicing Stimuli transcription speed Transcription termination Transcription, Genetic Transcriptome - physiology Transcriptomes
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