Expression regulation and function of PD-1 and PD-L1 in T lymphoma cells
•Human T lymphoma cells express both PD-1 and PD-L1.•TCR signaling activates PD-1 but represses PD-L1 expression in T lymphoma.•PD-L1 promotes T lymphoma growth in vivo.•PD-1 signaling pathways is impaired in vitro but promotes tumor growth in vivo. T lymphoma cells may constitutively express PD-1 a...
Gespeichert in:
| Veröffentlicht in: | Cellular immunology 2021-08, Vol.366, p.104397-104397, Article 104397 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 104397 |
|---|---|
| container_issue | |
| container_start_page | 104397 |
| container_title | Cellular immunology |
| container_volume | 366 |
| creator | Liu, Maria Y. Klement, John D. Langan, Candace J. van Riggelen, Jan Liu, Kebin |
| description | •Human T lymphoma cells express both PD-1 and PD-L1.•TCR signaling activates PD-1 but represses PD-L1 expression in T lymphoma.•PD-L1 promotes T lymphoma growth in vivo.•PD-1 signaling pathways is impaired in vitro but promotes tumor growth in vivo.
T lymphoma cells may constitutively express PD-1 and PD-L1. The relative role of PD-1 and PD-L1 in T lymphoma is incompletely understood. We report here that PD-1+ PDL-1+ human T lymphoma cells exhibit constitutive hyperactivation of the TCR signaling and do not respond to PD-L1-mediated suppression in vitro. Knocking out PD-1 or PD-L1 has no effects on T lymphoma cell apoptosis and proliferation in vitro, but significantly increased tumor-bearing mouse survival. Our findings determine that the constitutively active TCR signaling pathway maintain T lymphoma cell growth in vitro and that both PD-1 and PD-L1 promote T lymphoma growth in vivo. |
| doi_str_mv | 10.1016/j.cellimm.2021.104397 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8327398</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0008874921001167</els_id><sourcerecordid>2544460126</sourcerecordid><originalsourceid>FETCH-LOGICAL-c467t-916de2f09dced7daf84b4337b561e49addab3a84152459bb7ded401d206d39443</originalsourceid><addsrcrecordid>eNqFUU1PxCAUJEaj68dP0PTopSsPKC0XjfFrTTbRw3omtFBl05YVWqP_XuquRk-eeDzmzRtmEDoGPAUM_Gw5rUzT2LadEkwg9hgV-RaaABY4JcDpNppgjIu0yJnYQ_shLDEGYALvoj3KIMsZhwma3byvvAnBui7x5nloVD-WqtNJPXTV18XVyeN1Cl_NWMwhsV2ySJqPdvXiWpWMQsIh2qlVE8zR5jxAT7c3i6tZOn-4u7-6nKcV43mfCuDakBoLXRmda1UXrGSU5mXGwTChtFYlVUXUR1gmyjLXRjMMmmCuqWCMHqDzNe9qKFsTWbreq0auvG2V_5BOWfn3pbMv8tm9yYKSnIoiEpxuCLx7HUzoZWvD-AXVGTcESTLGGMdAeIRma2jlXQje1D9rAMsxBbmUmxTkmIJcpxDnTn5r_Jn6tj0CLtYAE516s8bLUFnTRUusN1UvtbP_rPgE3pibBA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2544460126</pqid></control><display><type>article</type><title>Expression regulation and function of PD-1 and PD-L1 in T lymphoma cells</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Liu, Maria Y. ; Klement, John D. ; Langan, Candace J. ; van Riggelen, Jan ; Liu, Kebin</creator><creatorcontrib>Liu, Maria Y. ; Klement, John D. ; Langan, Candace J. ; van Riggelen, Jan ; Liu, Kebin</creatorcontrib><description>•Human T lymphoma cells express both PD-1 and PD-L1.•TCR signaling activates PD-1 but represses PD-L1 expression in T lymphoma.•PD-L1 promotes T lymphoma growth in vivo.•PD-1 signaling pathways is impaired in vitro but promotes tumor growth in vivo.
T lymphoma cells may constitutively express PD-1 and PD-L1. The relative role of PD-1 and PD-L1 in T lymphoma is incompletely understood. We report here that PD-1+ PDL-1+ human T lymphoma cells exhibit constitutive hyperactivation of the TCR signaling and do not respond to PD-L1-mediated suppression in vitro. Knocking out PD-1 or PD-L1 has no effects on T lymphoma cell apoptosis and proliferation in vitro, but significantly increased tumor-bearing mouse survival. Our findings determine that the constitutively active TCR signaling pathway maintain T lymphoma cell growth in vitro and that both PD-1 and PD-L1 promote T lymphoma growth in vivo.</description><identifier>ISSN: 0008-8749</identifier><identifier>EISSN: 1090-2163</identifier><identifier>DOI: 10.1016/j.cellimm.2021.104397</identifier><identifier>PMID: 34157461</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Apoptosis ; B7-H1 Antigen - genetics ; B7-H1 Antigen - metabolism ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Lymphoma, T-Cell - immunology ; Mice ; Mice, Inbred C57BL ; Neoplasms, Experimental ; PD-1 ; PD-L1 ; Programmed Cell Death 1 Receptor - genetics ; Programmed Cell Death 1 Receptor - metabolism ; Receptors, Antigen, T-Cell - metabolism ; Signal Transduction ; T cell receptor ; T lymphoma ; Tumor Escape</subject><ispartof>Cellular immunology, 2021-08, Vol.366, p.104397-104397, Article 104397</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-916de2f09dced7daf84b4337b561e49addab3a84152459bb7ded401d206d39443</citedby><cites>FETCH-LOGICAL-c467t-916de2f09dced7daf84b4337b561e49addab3a84152459bb7ded401d206d39443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0008874921001167$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34157461$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Maria Y.</creatorcontrib><creatorcontrib>Klement, John D.</creatorcontrib><creatorcontrib>Langan, Candace J.</creatorcontrib><creatorcontrib>van Riggelen, Jan</creatorcontrib><creatorcontrib>Liu, Kebin</creatorcontrib><title>Expression regulation and function of PD-1 and PD-L1 in T lymphoma cells</title><title>Cellular immunology</title><addtitle>Cell Immunol</addtitle><description>•Human T lymphoma cells express both PD-1 and PD-L1.•TCR signaling activates PD-1 but represses PD-L1 expression in T lymphoma.•PD-L1 promotes T lymphoma growth in vivo.•PD-1 signaling pathways is impaired in vitro but promotes tumor growth in vivo.
T lymphoma cells may constitutively express PD-1 and PD-L1. The relative role of PD-1 and PD-L1 in T lymphoma is incompletely understood. We report here that PD-1+ PDL-1+ human T lymphoma cells exhibit constitutive hyperactivation of the TCR signaling and do not respond to PD-L1-mediated suppression in vitro. Knocking out PD-1 or PD-L1 has no effects on T lymphoma cell apoptosis and proliferation in vitro, but significantly increased tumor-bearing mouse survival. Our findings determine that the constitutively active TCR signaling pathway maintain T lymphoma cell growth in vitro and that both PD-1 and PD-L1 promote T lymphoma growth in vivo.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>B7-H1 Antigen - genetics</subject><subject>B7-H1 Antigen - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene Knockdown Techniques</subject><subject>Humans</subject><subject>Lymphoma, T-Cell - immunology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neoplasms, Experimental</subject><subject>PD-1</subject><subject>PD-L1</subject><subject>Programmed Cell Death 1 Receptor - genetics</subject><subject>Programmed Cell Death 1 Receptor - metabolism</subject><subject>Receptors, Antigen, T-Cell - metabolism</subject><subject>Signal Transduction</subject><subject>T cell receptor</subject><subject>T lymphoma</subject><subject>Tumor Escape</subject><issn>0008-8749</issn><issn>1090-2163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1PxCAUJEaj68dP0PTopSsPKC0XjfFrTTbRw3omtFBl05YVWqP_XuquRk-eeDzmzRtmEDoGPAUM_Gw5rUzT2LadEkwg9hgV-RaaABY4JcDpNppgjIu0yJnYQ_shLDEGYALvoj3KIMsZhwma3byvvAnBui7x5nloVD-WqtNJPXTV18XVyeN1Cl_NWMwhsV2ySJqPdvXiWpWMQsIh2qlVE8zR5jxAT7c3i6tZOn-4u7-6nKcV43mfCuDakBoLXRmda1UXrGSU5mXGwTChtFYlVUXUR1gmyjLXRjMMmmCuqWCMHqDzNe9qKFsTWbreq0auvG2V_5BOWfn3pbMv8tm9yYKSnIoiEpxuCLx7HUzoZWvD-AXVGTcESTLGGMdAeIRma2jlXQje1D9rAMsxBbmUmxTkmIJcpxDnTn5r_Jn6tj0CLtYAE516s8bLUFnTRUusN1UvtbP_rPgE3pibBA</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Liu, Maria Y.</creator><creator>Klement, John D.</creator><creator>Langan, Candace J.</creator><creator>van Riggelen, Jan</creator><creator>Liu, Kebin</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210801</creationdate><title>Expression regulation and function of PD-1 and PD-L1 in T lymphoma cells</title><author>Liu, Maria Y. ; Klement, John D. ; Langan, Candace J. ; van Riggelen, Jan ; Liu, Kebin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-916de2f09dced7daf84b4337b561e49addab3a84152459bb7ded401d206d39443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>B7-H1 Antigen - genetics</topic><topic>B7-H1 Antigen - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene Knockdown Techniques</topic><topic>Humans</topic><topic>Lymphoma, T-Cell - immunology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Neoplasms, Experimental</topic><topic>PD-1</topic><topic>PD-L1</topic><topic>Programmed Cell Death 1 Receptor - genetics</topic><topic>Programmed Cell Death 1 Receptor - metabolism</topic><topic>Receptors, Antigen, T-Cell - metabolism</topic><topic>Signal Transduction</topic><topic>T cell receptor</topic><topic>T lymphoma</topic><topic>Tumor Escape</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Maria Y.</creatorcontrib><creatorcontrib>Klement, John D.</creatorcontrib><creatorcontrib>Langan, Candace J.</creatorcontrib><creatorcontrib>van Riggelen, Jan</creatorcontrib><creatorcontrib>Liu, Kebin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Maria Y.</au><au>Klement, John D.</au><au>Langan, Candace J.</au><au>van Riggelen, Jan</au><au>Liu, Kebin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression regulation and function of PD-1 and PD-L1 in T lymphoma cells</atitle><jtitle>Cellular immunology</jtitle><addtitle>Cell Immunol</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>366</volume><spage>104397</spage><epage>104397</epage><pages>104397-104397</pages><artnum>104397</artnum><issn>0008-8749</issn><eissn>1090-2163</eissn><abstract>•Human T lymphoma cells express both PD-1 and PD-L1.•TCR signaling activates PD-1 but represses PD-L1 expression in T lymphoma.•PD-L1 promotes T lymphoma growth in vivo.•PD-1 signaling pathways is impaired in vitro but promotes tumor growth in vivo.
T lymphoma cells may constitutively express PD-1 and PD-L1. The relative role of PD-1 and PD-L1 in T lymphoma is incompletely understood. We report here that PD-1+ PDL-1+ human T lymphoma cells exhibit constitutive hyperactivation of the TCR signaling and do not respond to PD-L1-mediated suppression in vitro. Knocking out PD-1 or PD-L1 has no effects on T lymphoma cell apoptosis and proliferation in vitro, but significantly increased tumor-bearing mouse survival. Our findings determine that the constitutively active TCR signaling pathway maintain T lymphoma cell growth in vitro and that both PD-1 and PD-L1 promote T lymphoma growth in vivo.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>34157461</pmid><doi>10.1016/j.cellimm.2021.104397</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-8749 |
| ispartof | Cellular immunology, 2021-08, Vol.366, p.104397-104397, Article 104397 |
| issn | 0008-8749 1090-2163 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8327398 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Apoptosis B7-H1 Antigen - genetics B7-H1 Antigen - metabolism Cell Line, Tumor Cell Proliferation Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Humans Lymphoma, T-Cell - immunology Mice Mice, Inbred C57BL Neoplasms, Experimental PD-1 PD-L1 Programmed Cell Death 1 Receptor - genetics Programmed Cell Death 1 Receptor - metabolism Receptors, Antigen, T-Cell - metabolism Signal Transduction T cell receptor T lymphoma Tumor Escape |
| title | Expression regulation and function of PD-1 and PD-L1 in T lymphoma cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T00%3A01%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20regulation%20and%20function%20of%20PD-1%20and%20PD-L1%20in%20T%20lymphoma%20cells&rft.jtitle=Cellular%20immunology&rft.au=Liu,%20Maria%20Y.&rft.date=2021-08-01&rft.volume=366&rft.spage=104397&rft.epage=104397&rft.pages=104397-104397&rft.artnum=104397&rft.issn=0008-8749&rft.eissn=1090-2163&rft_id=info:doi/10.1016/j.cellimm.2021.104397&rft_dat=%3Cproquest_pubme%3E2544460126%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2544460126&rft_id=info:pmid/34157461&rft_els_id=S0008874921001167&rfr_iscdi=true |