Human milk 3’-Sialyllactose is positively associated with language development during infancy
Genetic polymorphisms leading to variations in human milk oligosaccharide (HMO) composition have been reported. Alpha-Tetrasaccharide (A-tetra), an HMO, has been shown to only be present (>limit of detection; A-tetra+) in the human milk (HM) of women with blood type A, suggesting genetic origins...
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| Veröffentlicht in: | The American journal of clinical nutrition 2021-08, Vol.114 (2), p.588-597 |
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| creator | Cho, Seoyoon Zhu, Ziliang Li, Tengfei Baluyot, Kristine Howell, Brittany R Hazlett, Heather C Elison, Jed T Hauser, Jonas Sprenger, Norbert Wu, Di Lin, Weili |
| description | Genetic polymorphisms leading to variations in human milk oligosaccharide (HMO) composition have been reported. Alpha-Tetrasaccharide (A-tetra), an HMO, has been shown to only be present (>limit of detection; A-tetra+) in the human milk (HM) of women with blood type A, suggesting genetic origins determining the presence or absence (A-tetra-) of A-tetra in HM.
This study aimed to determine whether associations exist between HMO concentrations and cognitive development, and whether the associations vary between A-tetra+ and A-tetra- groups in children ( |
| doi_str_mv | 10.1093/ajcn/nqab103 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8326052</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ajcn/nqab103</oup_id><els_id>S0002916522003732</els_id><sourcerecordid>2531234662</sourcerecordid><originalsourceid>FETCH-LOGICAL-c491t-11420c00663807f5f3bdd61b52f3be0ced292e4d8d37e8f9eb6f775904242f5f3</originalsourceid><addsrcrecordid>eNqFkUGLFDEQhYMo7jh68ywBD3qw3UrSne6-CLKoKyx4UM8hnVTPZuxOepPukbn5N_x7_hIzzLioCJ4SqK8e9d4j5DGDlwxaca63xp_7G90xEHfIirWiKQSH-i5ZAQAvWiarM_IgpS0A42Uj75MzUQKHshIroi6XUXs6uuELFT--fS8-Oj3sh0GbOSSkLtEpJDe7HQ57qlMKxukZLf3q5ms6aL9Z9AapxTwP04h-pnaJzm-o8732Zv-Q3Ov1kPDR6V2Tz2_ffLq4LK4-vHt_8fqqMGXL5oKxkoMBkFI0UPdVLzprJesqnn8IBi1vOZa2saLGpm-xk31dVy2UvOQHfE1eHXWnpRvRmnxJ1IOaoht13Kugnfpz4t212oSdagSXUPEs8PwkEMPNgmlWo0sGcxIew5IUrwTjopTygD79C92GJfpsL1NVXeWMs481eXGkTAwpRexvj2GgDs2pQ3Pq1FzGn_xu4Bb-VVUGnh2BsEz_k5JHEnPgO4dRJePQ5xBdRDMrG9y_F38C80C41g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2557548666</pqid></control><display><type>article</type><title>Human milk 3’-Sialyllactose is positively associated with language development during infancy</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Cho, Seoyoon ; Zhu, Ziliang ; Li, Tengfei ; Baluyot, Kristine ; Howell, Brittany R ; Hazlett, Heather C ; Elison, Jed T ; Hauser, Jonas ; Sprenger, Norbert ; Wu, Di ; Lin, Weili</creator><creatorcontrib>Cho, Seoyoon ; Zhu, Ziliang ; Li, Tengfei ; Baluyot, Kristine ; Howell, Brittany R ; Hazlett, Heather C ; Elison, Jed T ; Hauser, Jonas ; Sprenger, Norbert ; Wu, Di ; Lin, Weili</creatorcontrib><description>Genetic polymorphisms leading to variations in human milk oligosaccharide (HMO) composition have been reported. Alpha-Tetrasaccharide (A-tetra), an HMO, has been shown to only be present (>limit of detection; A-tetra+) in the human milk (HM) of women with blood type A, suggesting genetic origins determining the presence or absence (A-tetra-) of A-tetra in HM.
This study aimed to determine whether associations exist between HMO concentrations and cognitive development, and whether the associations vary between A-tetra+ and A-tetra- groups in children (<25 months old).
We enrolled typically developing children (2–25 months old; mean, 10 months old) who were at least partially breastfed at the study visit. The Mullen Scales of Early Learning (MSEL) were used as the primary outcome measure to assess early cognitive development. Linear mixed effects models were employed by stratifying children based on A-tetra levels (A-tetra+ or A-tetra-) to assess associations between age-removed HMO concentrations and both MSEL composite scores and the 5 subdomain scores.
A total of 99 mother-child dyads and 183 HM samples were included (A-tetra+: 57 samples, 33 dyads; A-tetra-: 126 samples, 66 dyads). No significant association was observed between HMOs and MSEL when all samples were analyzed together. The composite score and 3’-sialyllactose (3’-SL) levels were positively associated [P = 0.002; effect size (EF), 13.12; 95% CI, 5.36–20.80] in the A-tetra + group. This association was driven by the receptive (adjusted P = 0.015; EF, 9.95; 95% CI, 3.91–15.99) and expressive (adjusted P = 0.048; EF, 7.53; 95% CI, 2.51–13.79) language subdomain scores. Furthermore, there was an interaction between 3’-SL and age for receptive language (adjusted P = 0.03; EF, -14.93; 95% CI, -25.29 to -4.24).
Our study reports the association of 3’-SL and cognition, particularly language functions, in typically developing children who received HM containing detectable A-tetra during infancy.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/nqab103</identifier><identifier>PMID: 34020453</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Blood group A ; Blood groups ; Breast Feeding ; Breast milk ; breastfed infants ; Child, Preschool ; Children ; Cognition ; Cognitive ability ; Cognitive development ; early cognitive development ; Female ; Gene polymorphism ; Genetic diversity ; human milk ; human milk oligosaccharides ; Humans ; Infant ; Language ; Language Development ; Milk ; Milk, Human - chemistry ; Mullen Scales of Early Learning ; Oligosaccharides ; Oligosaccharides - chemistry ; Oligosaccharides - metabolism ; Oligosaccharides - pharmacology ; Original Research Communications ; random linear mixed effects model ; sialyllactose</subject><ispartof>The American journal of clinical nutrition, 2021-08, Vol.114 (2), p.588-597</ispartof><rights>2021 American Society for Nutrition.</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition. 2021</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Aug 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-11420c00663807f5f3bdd61b52f3be0ced292e4d8d37e8f9eb6f775904242f5f3</citedby><cites>FETCH-LOGICAL-c491t-11420c00663807f5f3bdd61b52f3be0ced292e4d8d37e8f9eb6f775904242f5f3</cites><orcidid>0000-0003-4880-2750 ; 0000-0002-7027-0781 ; 0000-0001-8331-2357</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34020453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cho, Seoyoon</creatorcontrib><creatorcontrib>Zhu, Ziliang</creatorcontrib><creatorcontrib>Li, Tengfei</creatorcontrib><creatorcontrib>Baluyot, Kristine</creatorcontrib><creatorcontrib>Howell, Brittany R</creatorcontrib><creatorcontrib>Hazlett, Heather C</creatorcontrib><creatorcontrib>Elison, Jed T</creatorcontrib><creatorcontrib>Hauser, Jonas</creatorcontrib><creatorcontrib>Sprenger, Norbert</creatorcontrib><creatorcontrib>Wu, Di</creatorcontrib><creatorcontrib>Lin, Weili</creatorcontrib><title>Human milk 3’-Sialyllactose is positively associated with language development during infancy</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>Genetic polymorphisms leading to variations in human milk oligosaccharide (HMO) composition have been reported. Alpha-Tetrasaccharide (A-tetra), an HMO, has been shown to only be present (>limit of detection; A-tetra+) in the human milk (HM) of women with blood type A, suggesting genetic origins determining the presence or absence (A-tetra-) of A-tetra in HM.
This study aimed to determine whether associations exist between HMO concentrations and cognitive development, and whether the associations vary between A-tetra+ and A-tetra- groups in children (<25 months old).
We enrolled typically developing children (2–25 months old; mean, 10 months old) who were at least partially breastfed at the study visit. The Mullen Scales of Early Learning (MSEL) were used as the primary outcome measure to assess early cognitive development. Linear mixed effects models were employed by stratifying children based on A-tetra levels (A-tetra+ or A-tetra-) to assess associations between age-removed HMO concentrations and both MSEL composite scores and the 5 subdomain scores.
A total of 99 mother-child dyads and 183 HM samples were included (A-tetra+: 57 samples, 33 dyads; A-tetra-: 126 samples, 66 dyads). No significant association was observed between HMOs and MSEL when all samples were analyzed together. The composite score and 3’-sialyllactose (3’-SL) levels were positively associated [P = 0.002; effect size (EF), 13.12; 95% CI, 5.36–20.80] in the A-tetra + group. This association was driven by the receptive (adjusted P = 0.015; EF, 9.95; 95% CI, 3.91–15.99) and expressive (adjusted P = 0.048; EF, 7.53; 95% CI, 2.51–13.79) language subdomain scores. Furthermore, there was an interaction between 3’-SL and age for receptive language (adjusted P = 0.03; EF, -14.93; 95% CI, -25.29 to -4.24).
Our study reports the association of 3’-SL and cognition, particularly language functions, in typically developing children who received HM containing detectable A-tetra during infancy.</description><subject>Adult</subject><subject>Blood group A</subject><subject>Blood groups</subject><subject>Breast Feeding</subject><subject>Breast milk</subject><subject>breastfed infants</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Cognitive development</subject><subject>early cognitive development</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genetic diversity</subject><subject>human milk</subject><subject>human milk oligosaccharides</subject><subject>Humans</subject><subject>Infant</subject><subject>Language</subject><subject>Language Development</subject><subject>Milk</subject><subject>Milk, Human - chemistry</subject><subject>Mullen Scales of Early Learning</subject><subject>Oligosaccharides</subject><subject>Oligosaccharides - chemistry</subject><subject>Oligosaccharides - metabolism</subject><subject>Oligosaccharides - pharmacology</subject><subject>Original Research Communications</subject><subject>random linear mixed effects model</subject><subject>sialyllactose</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><recordid>eNqFkUGLFDEQhYMo7jh68ywBD3qw3UrSne6-CLKoKyx4UM8hnVTPZuxOepPukbn5N_x7_hIzzLioCJ4SqK8e9d4j5DGDlwxaca63xp_7G90xEHfIirWiKQSH-i5ZAQAvWiarM_IgpS0A42Uj75MzUQKHshIroi6XUXs6uuELFT--fS8-Oj3sh0GbOSSkLtEpJDe7HQ57qlMKxukZLf3q5ms6aL9Z9AapxTwP04h-pnaJzm-o8732Zv-Q3Ov1kPDR6V2Tz2_ffLq4LK4-vHt_8fqqMGXL5oKxkoMBkFI0UPdVLzprJesqnn8IBi1vOZa2saLGpm-xk31dVy2UvOQHfE1eHXWnpRvRmnxJ1IOaoht13Kugnfpz4t212oSdagSXUPEs8PwkEMPNgmlWo0sGcxIew5IUrwTjopTygD79C92GJfpsL1NVXeWMs481eXGkTAwpRexvj2GgDs2pQ3Pq1FzGn_xu4Bb-VVUGnh2BsEz_k5JHEnPgO4dRJePQ5xBdRDMrG9y_F38C80C41g</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Cho, Seoyoon</creator><creator>Zhu, Ziliang</creator><creator>Li, Tengfei</creator><creator>Baluyot, Kristine</creator><creator>Howell, Brittany R</creator><creator>Hazlett, Heather C</creator><creator>Elison, Jed T</creator><creator>Hauser, Jonas</creator><creator>Sprenger, Norbert</creator><creator>Wu, Di</creator><creator>Lin, Weili</creator><general>Elsevier Inc</general><general>Oxford University Press</general><general>American Society for Clinical Nutrition, Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4880-2750</orcidid><orcidid>https://orcid.org/0000-0002-7027-0781</orcidid><orcidid>https://orcid.org/0000-0001-8331-2357</orcidid></search><sort><creationdate>20210801</creationdate><title>Human milk 3’-Sialyllactose is positively associated with language development during infancy</title><author>Cho, Seoyoon ; Zhu, Ziliang ; Li, Tengfei ; Baluyot, Kristine ; Howell, Brittany R ; Hazlett, Heather C ; Elison, Jed T ; Hauser, Jonas ; Sprenger, Norbert ; Wu, Di ; Lin, Weili</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-11420c00663807f5f3bdd61b52f3be0ced292e4d8d37e8f9eb6f775904242f5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Blood group A</topic><topic>Blood groups</topic><topic>Breast Feeding</topic><topic>Breast milk</topic><topic>breastfed infants</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Cognitive development</topic><topic>early cognitive development</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Genetic diversity</topic><topic>human milk</topic><topic>human milk oligosaccharides</topic><topic>Humans</topic><topic>Infant</topic><topic>Language</topic><topic>Language Development</topic><topic>Milk</topic><topic>Milk, Human - chemistry</topic><topic>Mullen Scales of Early Learning</topic><topic>Oligosaccharides</topic><topic>Oligosaccharides - chemistry</topic><topic>Oligosaccharides - metabolism</topic><topic>Oligosaccharides - pharmacology</topic><topic>Original Research Communications</topic><topic>random linear mixed effects model</topic><topic>sialyllactose</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cho, Seoyoon</creatorcontrib><creatorcontrib>Zhu, Ziliang</creatorcontrib><creatorcontrib>Li, Tengfei</creatorcontrib><creatorcontrib>Baluyot, Kristine</creatorcontrib><creatorcontrib>Howell, Brittany R</creatorcontrib><creatorcontrib>Hazlett, Heather C</creatorcontrib><creatorcontrib>Elison, Jed T</creatorcontrib><creatorcontrib>Hauser, Jonas</creatorcontrib><creatorcontrib>Sprenger, Norbert</creatorcontrib><creatorcontrib>Wu, Di</creatorcontrib><creatorcontrib>Lin, Weili</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Oxford Journals Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cho, Seoyoon</au><au>Zhu, Ziliang</au><au>Li, Tengfei</au><au>Baluyot, Kristine</au><au>Howell, Brittany R</au><au>Hazlett, Heather C</au><au>Elison, Jed T</au><au>Hauser, Jonas</au><au>Sprenger, Norbert</au><au>Wu, Di</au><au>Lin, Weili</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human milk 3’-Sialyllactose is positively associated with language development during infancy</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>114</volume><issue>2</issue><spage>588</spage><epage>597</epage><pages>588-597</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><abstract>Genetic polymorphisms leading to variations in human milk oligosaccharide (HMO) composition have been reported. Alpha-Tetrasaccharide (A-tetra), an HMO, has been shown to only be present (>limit of detection; A-tetra+) in the human milk (HM) of women with blood type A, suggesting genetic origins determining the presence or absence (A-tetra-) of A-tetra in HM.
This study aimed to determine whether associations exist between HMO concentrations and cognitive development, and whether the associations vary between A-tetra+ and A-tetra- groups in children (<25 months old).
We enrolled typically developing children (2–25 months old; mean, 10 months old) who were at least partially breastfed at the study visit. The Mullen Scales of Early Learning (MSEL) were used as the primary outcome measure to assess early cognitive development. Linear mixed effects models were employed by stratifying children based on A-tetra levels (A-tetra+ or A-tetra-) to assess associations between age-removed HMO concentrations and both MSEL composite scores and the 5 subdomain scores.
A total of 99 mother-child dyads and 183 HM samples were included (A-tetra+: 57 samples, 33 dyads; A-tetra-: 126 samples, 66 dyads). No significant association was observed between HMOs and MSEL when all samples were analyzed together. The composite score and 3’-sialyllactose (3’-SL) levels were positively associated [P = 0.002; effect size (EF), 13.12; 95% CI, 5.36–20.80] in the A-tetra + group. This association was driven by the receptive (adjusted P = 0.015; EF, 9.95; 95% CI, 3.91–15.99) and expressive (adjusted P = 0.048; EF, 7.53; 95% CI, 2.51–13.79) language subdomain scores. Furthermore, there was an interaction between 3’-SL and age for receptive language (adjusted P = 0.03; EF, -14.93; 95% CI, -25.29 to -4.24).
Our study reports the association of 3’-SL and cognition, particularly language functions, in typically developing children who received HM containing detectable A-tetra during infancy.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34020453</pmid><doi>10.1093/ajcn/nqab103</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-4880-2750</orcidid><orcidid>https://orcid.org/0000-0002-7027-0781</orcidid><orcidid>https://orcid.org/0000-0001-8331-2357</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | The American journal of clinical nutrition, 2021-08, Vol.114 (2), p.588-597 |
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| subjects | Adult Blood group A Blood groups Breast Feeding Breast milk breastfed infants Child, Preschool Children Cognition Cognitive ability Cognitive development early cognitive development Female Gene polymorphism Genetic diversity human milk human milk oligosaccharides Humans Infant Language Language Development Milk Milk, Human - chemistry Mullen Scales of Early Learning Oligosaccharides Oligosaccharides - chemistry Oligosaccharides - metabolism Oligosaccharides - pharmacology Original Research Communications random linear mixed effects model sialyllactose |
| title | Human milk 3’-Sialyllactose is positively associated with language development during infancy |
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