MAP2 is differentially phosphorylated in schizophrenia, altering its function

Schizophrenia (Sz) is a highly polygenic disorder, with common, rare, and structural variants each contributing only a small fraction of overall disease risk. Thus, there is a need to identify downstream points of convergence that can be targeted with therapeutics. Reduction of microtubule-associate...

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Veröffentlicht in:	Molecular psychiatry 2021-09, Vol.26 (9), p.5371-5388
Hauptverfasser:	Grubisha, M. J., Sun, X., MacDonald, M. L., Garver, M., Sun, Z., Paris, K. A., Patel, D. S., DeGiosio, R. A., Lewis, D. A., Yates, N. A., Camacho, C., Homanics, G. E., Ding, Y., Sweet, R. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 14/19 14/63 631/378 64/60 692/699/476/1799 82/1 82/58 Animals Behavioral Sciences Biological Psychology Computational neuroscience Dendritic spines Diagnosis Health aspects Immunoprecipitation Immunoreactivity Kinases MAP2 protein Mass spectroscopy Medicine Medicine & Public Health Mental disorders Mice Microtubule-associated protein 2 Microtubule-associated proteins Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Microtubules - metabolism Neural transmission Neurons - metabolism Neurosciences Pharmacotherapy Phosphorylation Physiological aspects Protein biosynthesis Protein research Protein structure Protein synthesis Proteins Psychiatry Psychological aspects Schizophrenia Schizophrenia - genetics Schizophrenia - metabolism Transgenic mice
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