Characterization of neoantigen-specific T cells in cancer resistant to immune checkpoint therapies

Neoantigen-specific T cells are strongly implicated as being critical for effective immune checkpoint blockade treatment (ICB) (e.g., anti–PD-1 and anti–CTLA-4) and are being targeted for vaccination-based therapies. However, ICB treatments show uneven responses between patients, and neoantigen vacc...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-07, Vol.118 (30), p.1-10
Hauptverfasser:	Li, Shamin, Simoni, Yannick, Zhuang, Summer, Gabel, Austin, Ma, Shaokang, Chee, Jonathan, Islas, Laura, Cessna, Anthony, Creaney, Jenette, Bradley, Robert K., Redwood, Alec, Robinson, Bruce W., Newell, Evan W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - immunology Antineoplastic Agents, Immunological - pharmacology Biological Sciences Cancer Carcinoma, Lewis Lung - drug therapy Carcinoma, Lewis Lung - immunology Carcinoma, Lewis Lung - metabolism Carcinoma, Lewis Lung - pathology CD8 antigen CD8-Positive T-Lymphocytes - immunology CTLA-4 protein Cytokines Cytometry Cytotoxicity Drug Resistance, Neoplasm Female Immune checkpoint Immunization Immunotherapy Lung carcinoma Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Major histocompatibility complex Mice Mice, Inbred C57BL Neoantigens PD-1 protein Phenotypes Regression Tumor-infiltrating lymphocytes Tumors Vaccination
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