Helicobacter pylori outer membrane vesicles induce expression and secretion of oncostatin M in AGS gastric cancer cells
Helicobacter pylori , a human pathogen that colonizes the stomach of 50% of the world’s population, is associated with gastritis, gastric adenocarcinoma, and mucosa-associated lymphoid tissue (MALT) lymphoma. Diseases are characterized by severe inflammatory responses in the stomach that are induced...
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| Veröffentlicht in: | Brazilian journal of microbiology 2021-09, Vol.52 (3), p.1057-1066 |
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| container_issue | 3 |
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| container_title | Brazilian journal of microbiology |
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| creator | Zoaiter, Malak Nasser, Roudaina Hage-Sleiman, Rouba Abdel-Sater, Fadi Badran, Bassam Zeaiter, Zaher |
| description | Helicobacter pylori
, a human pathogen that colonizes the stomach of 50% of the world’s population, is associated with gastritis, gastric adenocarcinoma, and mucosa-associated lymphoid tissue (MALT) lymphoma. Diseases are characterized by severe inflammatory responses in the stomach that are induced by various chemokines and cytokines. Recently, oncostatin M (OSM), an IL-6 family cytokine, was detected in early gastric cancer biopsies. In this study, we showed that
Helicobacter pylori
induced secretion of OSM and overexpression of its type II receptor OSMRβ (OSM/OSMRβ) in a human gastric adenocarcinoma cell line (AGS) over 24 h of infection. Furthermore, we showed that the induction of OSM and OSMRβ was carried out by heat-sensitive
Helicobacter pylori
outer membrane vesicle (OMV) protein. Collectively, our results established, for the first time, a direct relation between
Helicobacter pylori
OMVs and the OSM/OSMRβ signaling axis. |
| doi_str_mv | 10.1007/s42770-021-00490-7 |
| format | Article |
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, a human pathogen that colonizes the stomach of 50% of the world’s population, is associated with gastritis, gastric adenocarcinoma, and mucosa-associated lymphoid tissue (MALT) lymphoma. Diseases are characterized by severe inflammatory responses in the stomach that are induced by various chemokines and cytokines. Recently, oncostatin M (OSM), an IL-6 family cytokine, was detected in early gastric cancer biopsies. In this study, we showed that
Helicobacter pylori
induced secretion of OSM and overexpression of its type II receptor OSMRβ (OSM/OSMRβ) in a human gastric adenocarcinoma cell line (AGS) over 24 h of infection. Furthermore, we showed that the induction of OSM and OSMRβ was carried out by heat-sensitive
Helicobacter pylori
outer membrane vesicle (OMV) protein. Collectively, our results established, for the first time, a direct relation between
Helicobacter pylori
OMVs and the OSM/OSMRβ signaling axis.</description><identifier>ISSN: 1517-8382</identifier><identifier>EISSN: 1678-4405</identifier><identifier>DOI: 10.1007/s42770-021-00490-7</identifier><identifier>PMID: 33851342</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adenocarcinoma ; Adenocarcinoma - metabolism ; Bacterial and Fungal Pathogenesis - Research Paper ; Bacterial Outer Membrane ; Bacteriology ; Biomedical and Life Sciences ; Cancer ; Cardiology and cardiovascular system ; Chemokines ; Cytokines ; Emerging diseases ; Food Microbiology ; Gastric cancer ; Gastric Mucosa ; Gastritis ; Helicobacter Infections - metabolism ; Helicobacter pylori ; Helicobacter pylori - genetics ; Human health and pathology ; Humans ; Infectious diseases ; Inflammation ; Interleukin 6 ; Life Sciences ; Lymphoma ; Medical Microbiology ; Membrane proteins ; Membrane vesicles ; Membranes ; Microbial Ecology ; Microbial Genetics and Genomics ; Microbiology ; Microbiology and Parasitology ; Mucosa ; Mucosal-associated lymphoid tissue ; Mycology ; Oncostatin M ; Oncostatin M - metabolism ; Oncostatin M Receptor beta Subunit - metabolism ; Parasitology ; Signal Transduction ; Stomach ; Stomach Neoplasms - metabolism ; Virology</subject><ispartof>Brazilian journal of microbiology, 2021-09, Vol.52 (3), p.1057-1066</ispartof><rights>Sociedade Brasileira de Microbiologia 2021</rights><rights>2021. Sociedade Brasileira de Microbiologia.</rights><rights>Sociedade Brasileira de Microbiologia 2021.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-9fa8e579ec3fc664c288d9f594f8fcfb513b5e710c70f9464c57505eb1ef83ac3</citedby><cites>FETCH-LOGICAL-c508t-9fa8e579ec3fc664c288d9f594f8fcfb513b5e710c70f9464c57505eb1ef83ac3</cites><orcidid>0000-0003-2312-5001</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324738/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324738/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33851342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://amu.hal.science/hal-03243234$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Zoaiter, Malak</creatorcontrib><creatorcontrib>Nasser, Roudaina</creatorcontrib><creatorcontrib>Hage-Sleiman, Rouba</creatorcontrib><creatorcontrib>Abdel-Sater, Fadi</creatorcontrib><creatorcontrib>Badran, Bassam</creatorcontrib><creatorcontrib>Zeaiter, Zaher</creatorcontrib><title>Helicobacter pylori outer membrane vesicles induce expression and secretion of oncostatin M in AGS gastric cancer cells</title><title>Brazilian journal of microbiology</title><addtitle>Braz J Microbiol</addtitle><addtitle>Braz J Microbiol</addtitle><description>Helicobacter pylori
, a human pathogen that colonizes the stomach of 50% of the world’s population, is associated with gastritis, gastric adenocarcinoma, and mucosa-associated lymphoid tissue (MALT) lymphoma. Diseases are characterized by severe inflammatory responses in the stomach that are induced by various chemokines and cytokines. Recently, oncostatin M (OSM), an IL-6 family cytokine, was detected in early gastric cancer biopsies. In this study, we showed that
Helicobacter pylori
induced secretion of OSM and overexpression of its type II receptor OSMRβ (OSM/OSMRβ) in a human gastric adenocarcinoma cell line (AGS) over 24 h of infection. Furthermore, we showed that the induction of OSM and OSMRβ was carried out by heat-sensitive
Helicobacter pylori
outer membrane vesicle (OMV) protein. Collectively, our results established, for the first time, a direct relation between
Helicobacter pylori
OMVs and the OSM/OSMRβ signaling axis.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - metabolism</subject><subject>Bacterial and Fungal Pathogenesis - Research Paper</subject><subject>Bacterial Outer Membrane</subject><subject>Bacteriology</subject><subject>Biomedical and Life Sciences</subject><subject>Cancer</subject><subject>Cardiology and cardiovascular system</subject><subject>Chemokines</subject><subject>Cytokines</subject><subject>Emerging diseases</subject><subject>Food Microbiology</subject><subject>Gastric cancer</subject><subject>Gastric Mucosa</subject><subject>Gastritis</subject><subject>Helicobacter Infections - metabolism</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - genetics</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Life Sciences</subject><subject>Lymphoma</subject><subject>Medical Microbiology</subject><subject>Membrane proteins</subject><subject>Membrane vesicles</subject><subject>Membranes</subject><subject>Microbial Ecology</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbiology</subject><subject>Microbiology and Parasitology</subject><subject>Mucosa</subject><subject>Mucosal-associated lymphoid tissue</subject><subject>Mycology</subject><subject>Oncostatin M</subject><subject>Oncostatin M - metabolism</subject><subject>Oncostatin M Receptor beta Subunit - metabolism</subject><subject>Parasitology</subject><subject>Signal Transduction</subject><subject>Stomach</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Virology</subject><issn>1517-8382</issn><issn>1678-4405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk1v1DAQhiMEoqXwBzggS1zgkNafsXNBWlXQRVrUA3C2HO946yqxFzvZ0n-PQ0opPXCyx_PMOx-eqnpN8CnBWJ5lTqXENaakxpi3uJZPqmPSSFVzjsXTchdE1oopelS9yPkaYyowp8-rI8aUIIzT4-pmDb23sTN2hIT2t31MHsVpNgYYumQCoANkb3vIyIftZAHBz32CnH0MyIQtymATjLMVHYrBxjya0Qf0pfBodfEV7Uwek7fImmCLroW-zy-rZ870GV7dnSfV908fv52v683lxefz1aa2Aquxbp1RIGQLljnbNNxSpbatEy13ylnXlS46AZJgK7FreQGEFFhAR8ApZiw7qT4suvupG2BrIYzJ9Hqf_GDSrY7G6389wV_pXTxoxSiXTBWB94vA1aOw9Wqj5zdcQEYZP5DCvrtLluKPCfKoB5_ndssU45Q1FYRKWsrEBX37CL2OUwplFIUSjWpaqlih6ELZFHNO4O4rIFjPO6CXHdBlB_TvHdCyBL152PJ9yJ9PLwBbgFxcYQfpb-7_yP4CPWa-Pw</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Zoaiter, Malak</creator><creator>Nasser, Roudaina</creator><creator>Hage-Sleiman, Rouba</creator><creator>Abdel-Sater, Fadi</creator><creator>Badran, Bassam</creator><creator>Zeaiter, Zaher</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><general>Sociedade Brasileira de Microbiologia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2312-5001</orcidid></search><sort><creationdate>20210901</creationdate><title>Helicobacter pylori outer membrane vesicles induce expression and secretion of oncostatin M in AGS gastric cancer cells</title><author>Zoaiter, Malak ; Nasser, Roudaina ; Hage-Sleiman, Rouba ; Abdel-Sater, Fadi ; Badran, Bassam ; Zeaiter, Zaher</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-9fa8e579ec3fc664c288d9f594f8fcfb513b5e710c70f9464c57505eb1ef83ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - metabolism</topic><topic>Bacterial and Fungal Pathogenesis - Research Paper</topic><topic>Bacterial Outer Membrane</topic><topic>Bacteriology</topic><topic>Biomedical and Life Sciences</topic><topic>Cancer</topic><topic>Cardiology and cardiovascular system</topic><topic>Chemokines</topic><topic>Cytokines</topic><topic>Emerging diseases</topic><topic>Food Microbiology</topic><topic>Gastric cancer</topic><topic>Gastric Mucosa</topic><topic>Gastritis</topic><topic>Helicobacter Infections - metabolism</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - genetics</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Life Sciences</topic><topic>Lymphoma</topic><topic>Medical Microbiology</topic><topic>Membrane proteins</topic><topic>Membrane vesicles</topic><topic>Membranes</topic><topic>Microbial Ecology</topic><topic>Microbial Genetics and Genomics</topic><topic>Microbiology</topic><topic>Microbiology and Parasitology</topic><topic>Mucosa</topic><topic>Mucosal-associated lymphoid tissue</topic><topic>Mycology</topic><topic>Oncostatin M</topic><topic>Oncostatin M - metabolism</topic><topic>Oncostatin M Receptor beta Subunit - metabolism</topic><topic>Parasitology</topic><topic>Signal Transduction</topic><topic>Stomach</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zoaiter, Malak</creatorcontrib><creatorcontrib>Nasser, Roudaina</creatorcontrib><creatorcontrib>Hage-Sleiman, Rouba</creatorcontrib><creatorcontrib>Abdel-Sater, Fadi</creatorcontrib><creatorcontrib>Badran, Bassam</creatorcontrib><creatorcontrib>Zeaiter, Zaher</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brazilian journal of microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zoaiter, Malak</au><au>Nasser, Roudaina</au><au>Hage-Sleiman, Rouba</au><au>Abdel-Sater, Fadi</au><au>Badran, Bassam</au><au>Zeaiter, Zaher</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Helicobacter pylori outer membrane vesicles induce expression and secretion of oncostatin M in AGS gastric cancer cells</atitle><jtitle>Brazilian journal of microbiology</jtitle><stitle>Braz J Microbiol</stitle><addtitle>Braz J Microbiol</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>52</volume><issue>3</issue><spage>1057</spage><epage>1066</epage><pages>1057-1066</pages><issn>1517-8382</issn><eissn>1678-4405</eissn><abstract>Helicobacter pylori
, a human pathogen that colonizes the stomach of 50% of the world’s population, is associated with gastritis, gastric adenocarcinoma, and mucosa-associated lymphoid tissue (MALT) lymphoma. Diseases are characterized by severe inflammatory responses in the stomach that are induced by various chemokines and cytokines. Recently, oncostatin M (OSM), an IL-6 family cytokine, was detected in early gastric cancer biopsies. In this study, we showed that
Helicobacter pylori
induced secretion of OSM and overexpression of its type II receptor OSMRβ (OSM/OSMRβ) in a human gastric adenocarcinoma cell line (AGS) over 24 h of infection. Furthermore, we showed that the induction of OSM and OSMRβ was carried out by heat-sensitive
Helicobacter pylori
outer membrane vesicle (OMV) protein. Collectively, our results established, for the first time, a direct relation between
Helicobacter pylori
OMVs and the OSM/OSMRβ signaling axis.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33851342</pmid><doi>10.1007/s42770-021-00490-7</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-2312-5001</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1517-8382 |
| ispartof | Brazilian journal of microbiology, 2021-09, Vol.52 (3), p.1057-1066 |
| issn | 1517-8382 1678-4405 |
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| source | MEDLINE; PMC (PubMed Central); Springer Journals; Alma/SFX Local Collection |
| subjects | Adenocarcinoma Adenocarcinoma - metabolism Bacterial and Fungal Pathogenesis - Research Paper Bacterial Outer Membrane Bacteriology Biomedical and Life Sciences Cancer Cardiology and cardiovascular system Chemokines Cytokines Emerging diseases Food Microbiology Gastric cancer Gastric Mucosa Gastritis Helicobacter Infections - metabolism Helicobacter pylori Helicobacter pylori - genetics Human health and pathology Humans Infectious diseases Inflammation Interleukin 6 Life Sciences Lymphoma Medical Microbiology Membrane proteins Membrane vesicles Membranes Microbial Ecology Microbial Genetics and Genomics Microbiology Microbiology and Parasitology Mucosa Mucosal-associated lymphoid tissue Mycology Oncostatin M Oncostatin M - metabolism Oncostatin M Receptor beta Subunit - metabolism Parasitology Signal Transduction Stomach Stomach Neoplasms - metabolism Virology |
| title | Helicobacter pylori outer membrane vesicles induce expression and secretion of oncostatin M in AGS gastric cancer cells |
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