The TNFRSF11B mutation associated with calcium pyrophosphate deposition disease results in ineffective osteoclast suppression

TNFRSF11B encodes for osteoprotegerin (OPG) and was recently identified as the CCAL1 locus associated with familial calcium pyrophosphate deposition disease (CPDD). While the CCAL1 OPG mutation (OPG-XL) was originally believed to be a gain-of-function, loss of OPG activity causes arthritis-associate...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2021-06, Vol.73 (8), p.1543-1549
Hauptverfasser:	Mitton-Fitzgerald, Elizabeth, Gohr, Claudia M, Williams, Charlene J, Ortiz, Amaryllis, Mbalaviele, Gabriel, Rosenthal, Ann K
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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