EOMES and IL-10 regulate antitumor activity of T regulatory type 1 CD4+ T cells in chronic lymphocytic leukemia

The transcription factor eomesodermin (EOMES) promotes interleukin (IL)-10 expression in CD4 + T cells, which has been linked to immunosuppressive and cytotoxic activities. We detected cytotoxic, programmed cell death protein-1 (PD-1) and EOMES co-expressing CD4 + T cells in lymph nodes (LNs) of pat...

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Veröffentlicht in:	Leukemia 2021-08, Vol.35 (8), p.2311-2324
Hauptverfasser:	Roessner, Philipp M., Llaó Cid, Laura, Lupar, Ekaterina, Roider, Tobias, Bordas, Marie, Schifflers, Christoph, Arseni, Lavinia, Gaupel, Ann-Christin, Kilpert, Fabian, Krötschel, Marit, Arnold, Sebastian J., Sellner, Leopold, Colomer, Dolors, Stilgenbauer, Stephan, Dietrich, Sascha, Lichter, Peter, Izcue, Ana, Seiffert, Martina
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 42/35 631/250/1619/554/1898 631/250/580/1884 631/67/1990/283/1895 631/67/1990/291/1621 631/67/327 64/110 96/21 Adoptive transfer Animals Anticancer properties Antitumor activity Apoptosis B-cell lymphoma Cancer Research CD4 antigen CD4-Positive T-Lymphocytes - immunology Cell death Cell Differentiation Chronic lymphocytic leukemia Critical Care Medicine Cytotoxicity Female Flow cytometry Gene Expression Regulation, Leukemic Hematology Humans Intensive Interferon Interferon-gamma Interleukin 1 Interleukin 10 Interleukin-10 - genetics Interleukin-10 - metabolism Internal Medicine Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - immunology Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemia, Lymphocytic, Chronic, B-Cell - pathology Leukemia, Lymphocytic, Chronic, B-Cell - prevention & control Lymph nodes Lymphatic leukemia Lymphocytes Lymphocytes B Lymphocytes T Lymphoma Medicine Medicine & Public Health Mice Mice, Inbred C57BL Oncology PD-1 protein Prognosis RAG2 protein Receptors Signal Transduction T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Regulatory - immunology Th1 Cells - immunology Transcriptome Transcriptomes Tumor Cells, Cultured
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