Different evolutionary pathways of HIV-1 between fetus and mother perinatal transmission pairs indicate unique immune selection in fetuses

Study of evolution and selection pressure on HIV-1 in fetuses will lead to a better understanding of the role of immune responses in shaping virus evolution and vertical transmission. Detailed genetic analyses of HIV-1 env gene from 12 in utero transmission pairs show that most infections (67%) occu...

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Veröffentlicht in:	Cell reports. Medicine 2021-07, Vol.2 (7), p.100315-100315, Article 100315
Hauptverfasser:	Marichannegowda, Manukumar Honnayakanahalli, Mengual, Michael, Kumar, Amit, Giorgi, Elena E., Tu, Joshua J., Martinez, David R., Romero-Severson, Ethan O., Li, Xiaojun, Feng, Liping, Permar, Sallie R., Gao, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Base Sequence Biological Evolution biological science Cell Line env Gene Products, Human Immunodeficiency Virus Female fetus Fetus - immunology Fetus - virology Genetic Variation HIV Infections - blood HIV Infections - virology HIV, mother-to-child transmission HIV-1 HIV-1 - physiology Host-Pathogen Interactions - immunology Humans immune selection in utero transmission Infant, Newborn Infectious Disease Transmission, Vertical mother to child transmission Mothers neonate Neutralization Tests Nucleotide Motifs - genetics Phylogeny Placenta - metabolism Pregnancy signature Young Adult
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