Intercellular communication and conjugation are mediated by ESX secretion systems in mycobacteria

Communal bacterial processes require intercellular communication mediated by secretion systems to coordinate appropriate molecular responses. Intercellular communication has not been described previously in mycobacteria. Here we show that the ESX secretion-system family member ESX-4 is essential for...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2016-10, Vol.354 (6310), p.347-350
Hauptverfasser:	Gray, Todd A., Clark, Ryan R., Boucher, Nathalie, Lapierre, Pascal, Smith, Carol, Derbyshire, Keith M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amplification Bacteria Bacterial proteins Bacterial Proteins - genetics Bacterial Proteins - metabolism Cellular biology Channels Conjugation Conjugation, Genetic - genetics Deoxyribonucleic acid DNA Donors Exchange Gene Expression Regulation, Bacterial Mathematical models Mutation Mycobacterium smegmatis Mycobacterium smegmatis - genetics Mycobacterium smegmatis - metabolism Secretions Transcription, Genetic Type VII Secretion Systems - genetics Type VII Secretion Systems - metabolism
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