Dlg1 Maintains Dendritic Cell Function by Securing Voltage-Gated K + Channel Integrity

Dendritic cells (DCs) play key roles in Ab responses by presenting Ags to lymphocytes and by producing proinflammatory cytokines. In this study, we reported that DC-specific knockout of discs large homologue 1 (Dlg1) resulted in a significantly reduced capacity to mediate Ab responses to both thymus...

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Veröffentlicht in:	The Journal of immunology (1950) 2019-06, Vol.202 (11), p.3187-3197
Hauptverfasser:	Dong, Xuejiao, Wei, Lisi, Guo, Xueheng, Yang, Zhiyong, Wu, Chuan, Li, Peiyu, Lu, Lu, Qi, Hai, Shi, Yan, Hu, Xiaoyu, Wu, Li, Chen, Liangyi, Liu, Wanli
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation - genetics Antigen Presentation Calcium Signaling Cells, Cultured Cytokines - metabolism Dendritic Cells - immunology Discs Large Homolog 1 Protein - genetics Discs Large Homolog 1 Protein - metabolism Endocytosis - genetics Gene Expression Regulation Membrane Potentials Mice Mice, Inbred C57BL Mice, Knockout Potassium Channels, Voltage-Gated - genetics Potassium Channels, Voltage-Gated - metabolism
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