Variable immunogenicity of a vivax malaria blood-stage vaccine candidate
•We evaluated the immunogenicity of a rDBPII vaccine with different variables.•Significant variations in immune responses were observed with different variables.•No specific pattern in immune responses with respect to sex or adjuvant observed.•Sex and immune genes are critical variables to consider...
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| Veröffentlicht in: | Vaccine 2021-05, Vol.39 (19), p.2668-2675 |
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| creator | De, Sai Lata May, Samuel Shah, Keshav Slawinski, Michelle Changrob, Siriruk Xu, Shulin Barnes, Samantha J. Chootong, Patchanee Ntumngia, Francis B. Adams, John H. |
| description | •We evaluated the immunogenicity of a rDBPII vaccine with different variables.•Significant variations in immune responses were observed with different variables.•No specific pattern in immune responses with respect to sex or adjuvant observed.•Sex and immune genes are critical variables to consider in vaccine study design.
Relapsing malaria caused by Plasmodium vivax is a neglected tropical disease and an important cause of malaria worldwide. Vaccines to prevent clinical disease and mosquito transmission of vivax malaria are needed to overcome the distinct challenges of this important public health problem. In this vaccine immunogenicity study in mice, we examined key variables of responses to a P. vivax Duffy binding protein vaccine, a leading candidate to prevent the disease-causing blood-stages. Significant sex-dependent differences were observed in B cell (CD80+) and T cell (CD8+) central memory subsets, resulting in significant differences in functional immunogenicity and durability of anti-DBP protective efficacy. These significant sex-dependent differences in inbred mice were in the CD73+CD80+ memory B cell, H2KhiCD38hi/lo, and effector memory subsets. This study highlights sex and immune genes as critical variables that can impact host responses to P. vivax antigens and must be taken into consideration when designing clinical vaccine studies. |
| doi_str_mv | 10.1016/j.vaccine.2021.03.072 |
| format | Article |
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Relapsing malaria caused by Plasmodium vivax is a neglected tropical disease and an important cause of malaria worldwide. Vaccines to prevent clinical disease and mosquito transmission of vivax malaria are needed to overcome the distinct challenges of this important public health problem. In this vaccine immunogenicity study in mice, we examined key variables of responses to a P. vivax Duffy binding protein vaccine, a leading candidate to prevent the disease-causing blood-stages. Significant sex-dependent differences were observed in B cell (CD80+) and T cell (CD8+) central memory subsets, resulting in significant differences in functional immunogenicity and durability of anti-DBP protective efficacy. These significant sex-dependent differences in inbred mice were in the CD73+CD80+ memory B cell, H2KhiCD38hi/lo, and effector memory subsets. This study highlights sex and immune genes as critical variables that can impact host responses to P. vivax antigens and must be taken into consideration when designing clinical vaccine studies.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2021.03.072</identifier><identifier>PMID: 33840564</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; Antibodies ; Antibodies, Protozoan ; Antigens ; Antigens, Protozoan ; Blood ; CD73 antigen ; CD8 antigen ; CD80 antigen ; Disease transmission ; Females ; Gene expression ; Immunogenicity ; Immunological memory ; Inbreeding ; Infections ; Lymphocytes ; Lymphocytes T ; Malaria ; Malaria Vaccines ; Malaria, Vivax - prevention & control ; Males ; Memory B cells ; Memory cells ; Mice ; Phosphatase ; Plasmodium vivax ; Protozoan Proteins - genetics ; Public health ; Sex ; Sex as a biological variable ; Software ; Vaccine ; Vaccines ; Vector-borne diseases</subject><ispartof>Vaccine, 2021-05, Vol.39 (19), p.2668-2675</ispartof><rights>2021 The Author(s)</rights><rights>Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.</rights><rights>2021. The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-72d5c80f7281eca1e7c2ac784347d19fcd95c3fa304f412f54b349406b63249a3</citedby><cites>FETCH-LOGICAL-c495t-72d5c80f7281eca1e7c2ac784347d19fcd95c3fa304f412f54b349406b63249a3</cites><orcidid>0000-0002-6662-1307</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2518690585?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33840564$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De, Sai Lata</creatorcontrib><creatorcontrib>May, Samuel</creatorcontrib><creatorcontrib>Shah, Keshav</creatorcontrib><creatorcontrib>Slawinski, Michelle</creatorcontrib><creatorcontrib>Changrob, Siriruk</creatorcontrib><creatorcontrib>Xu, Shulin</creatorcontrib><creatorcontrib>Barnes, Samantha J.</creatorcontrib><creatorcontrib>Chootong, Patchanee</creatorcontrib><creatorcontrib>Ntumngia, Francis B.</creatorcontrib><creatorcontrib>Adams, John H.</creatorcontrib><title>Variable immunogenicity of a vivax malaria blood-stage vaccine candidate</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>•We evaluated the immunogenicity of a rDBPII vaccine with different variables.•Significant variations in immune responses were observed with different variables.•No specific pattern in immune responses with respect to sex or adjuvant observed.•Sex and immune genes are critical variables to consider in vaccine study design.
Relapsing malaria caused by Plasmodium vivax is a neglected tropical disease and an important cause of malaria worldwide. Vaccines to prevent clinical disease and mosquito transmission of vivax malaria are needed to overcome the distinct challenges of this important public health problem. In this vaccine immunogenicity study in mice, we examined key variables of responses to a P. vivax Duffy binding protein vaccine, a leading candidate to prevent the disease-causing blood-stages. Significant sex-dependent differences were observed in B cell (CD80+) and T cell (CD8+) central memory subsets, resulting in significant differences in functional immunogenicity and durability of anti-DBP protective efficacy. These significant sex-dependent differences in inbred mice were in the CD73+CD80+ memory B cell, H2KhiCD38hi/lo, and effector memory subsets. This study highlights sex and immune genes as critical variables that can impact host responses to P. vivax antigens and must be taken into consideration when designing clinical vaccine studies.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Protozoan</subject><subject>Antigens</subject><subject>Antigens, Protozoan</subject><subject>Blood</subject><subject>CD73 antigen</subject><subject>CD8 antigen</subject><subject>CD80 antigen</subject><subject>Disease transmission</subject><subject>Females</subject><subject>Gene expression</subject><subject>Immunogenicity</subject><subject>Immunological memory</subject><subject>Inbreeding</subject><subject>Infections</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Malaria</subject><subject>Malaria Vaccines</subject><subject>Malaria, Vivax - prevention & control</subject><subject>Males</subject><subject>Memory B cells</subject><subject>Memory cells</subject><subject>Mice</subject><subject>Phosphatase</subject><subject>Plasmodium vivax</subject><subject>Protozoan Proteins - genetics</subject><subject>Public health</subject><subject>Sex</subject><subject>Sex as a biological variable</subject><subject>Software</subject><subject>Vaccine</subject><subject>Vaccines</subject><subject>Vector-borne diseases</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU9v1DAQxS0EotvCRwBF4sIlqf8m9gVUVdAiVeICiJvl2JPFq8QudhLRb1-vdqmgl57mML95M_MeQm8Ibggm7fmuWY21PkBDMSUNZg3u6DO0IbJjNRVEPkcbTFtec4J_nqDTnHcYY8GIeolOGJMci5Zv0PUPk7zpR6j8NC0hbiF46-e7Kg6VqVa_mj_VZMY9VPVjjK7Os9lCdVxeWROcd2aGV-jFYMYMr4_1DH3__Onb5XV98_Xqy-XFTW25EnPdUSesxENHJQFrCHSWGttJznjniBqsU8KywTDMB07oIHjPuOK47VtGuTLsDH046N4u_QTOQpiTGfVt8pNJdzoar__vBP9Lb-OqJaNMYFUE3h8FUvy9QJ715LOFcTQB4pJ18Y5IJYkiBX33CN3FJYXy3p6SrcJCikKJA2VTzDnB8HAMwXqfld7po116n5XGTJesytzbfz95mPobTgE-HgAofq4eks7WQ7DgfAI7axf9EyvuAeNRqB0</recordid><startdate>20210506</startdate><enddate>20210506</enddate><creator>De, Sai Lata</creator><creator>May, Samuel</creator><creator>Shah, Keshav</creator><creator>Slawinski, Michelle</creator><creator>Changrob, Siriruk</creator><creator>Xu, Shulin</creator><creator>Barnes, Samantha J.</creator><creator>Chootong, Patchanee</creator><creator>Ntumngia, Francis B.</creator><creator>Adams, John H.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6662-1307</orcidid></search><sort><creationdate>20210506</creationdate><title>Variable immunogenicity of a vivax malaria blood-stage vaccine candidate</title><author>De, Sai Lata ; May, Samuel ; Shah, Keshav ; Slawinski, Michelle ; Changrob, Siriruk ; Xu, Shulin ; Barnes, Samantha J. ; Chootong, Patchanee ; Ntumngia, Francis B. ; Adams, John H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-72d5c80f7281eca1e7c2ac784347d19fcd95c3fa304f412f54b349406b63249a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Protozoan</topic><topic>Antigens</topic><topic>Antigens, Protozoan</topic><topic>Blood</topic><topic>CD73 antigen</topic><topic>CD8 antigen</topic><topic>CD80 antigen</topic><topic>Disease transmission</topic><topic>Females</topic><topic>Gene expression</topic><topic>Immunogenicity</topic><topic>Immunological memory</topic><topic>Inbreeding</topic><topic>Infections</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Malaria</topic><topic>Malaria Vaccines</topic><topic>Malaria, Vivax - prevention & control</topic><topic>Males</topic><topic>Memory B cells</topic><topic>Memory cells</topic><topic>Mice</topic><topic>Phosphatase</topic><topic>Plasmodium vivax</topic><topic>Protozoan Proteins - genetics</topic><topic>Public health</topic><topic>Sex</topic><topic>Sex as a biological variable</topic><topic>Software</topic><topic>Vaccine</topic><topic>Vaccines</topic><topic>Vector-borne diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De, Sai Lata</creatorcontrib><creatorcontrib>May, Samuel</creatorcontrib><creatorcontrib>Shah, Keshav</creatorcontrib><creatorcontrib>Slawinski, Michelle</creatorcontrib><creatorcontrib>Changrob, Siriruk</creatorcontrib><creatorcontrib>Xu, Shulin</creatorcontrib><creatorcontrib>Barnes, Samantha J.</creatorcontrib><creatorcontrib>Chootong, Patchanee</creatorcontrib><creatorcontrib>Ntumngia, Francis B.</creatorcontrib><creatorcontrib>Adams, John H.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De, Sai Lata</au><au>May, Samuel</au><au>Shah, Keshav</au><au>Slawinski, Michelle</au><au>Changrob, Siriruk</au><au>Xu, Shulin</au><au>Barnes, Samantha J.</au><au>Chootong, Patchanee</au><au>Ntumngia, Francis B.</au><au>Adams, John H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variable immunogenicity of a vivax malaria blood-stage vaccine candidate</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2021-05-06</date><risdate>2021</risdate><volume>39</volume><issue>19</issue><spage>2668</spage><epage>2675</epage><pages>2668-2675</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>•We evaluated the immunogenicity of a rDBPII vaccine with different variables.•Significant variations in immune responses were observed with different variables.•No specific pattern in immune responses with respect to sex or adjuvant observed.•Sex and immune genes are critical variables to consider in vaccine study design.
Relapsing malaria caused by Plasmodium vivax is a neglected tropical disease and an important cause of malaria worldwide. Vaccines to prevent clinical disease and mosquito transmission of vivax malaria are needed to overcome the distinct challenges of this important public health problem. In this vaccine immunogenicity study in mice, we examined key variables of responses to a P. vivax Duffy binding protein vaccine, a leading candidate to prevent the disease-causing blood-stages. Significant sex-dependent differences were observed in B cell (CD80+) and T cell (CD8+) central memory subsets, resulting in significant differences in functional immunogenicity and durability of anti-DBP protective efficacy. These significant sex-dependent differences in inbred mice were in the CD73+CD80+ memory B cell, H2KhiCD38hi/lo, and effector memory subsets. This study highlights sex and immune genes as critical variables that can impact host responses to P. vivax antigens and must be taken into consideration when designing clinical vaccine studies.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>33840564</pmid><doi>10.1016/j.vaccine.2021.03.072</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6662-1307</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Vaccine, 2021-05, Vol.39 (19), p.2668-2675 |
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| subjects | Animals Antibodies Antibodies, Protozoan Antigens Antigens, Protozoan Blood CD73 antigen CD8 antigen CD80 antigen Disease transmission Females Gene expression Immunogenicity Immunological memory Inbreeding Infections Lymphocytes Lymphocytes T Malaria Malaria Vaccines Malaria, Vivax - prevention & control Males Memory B cells Memory cells Mice Phosphatase Plasmodium vivax Protozoan Proteins - genetics Public health Sex Sex as a biological variable Software Vaccine Vaccines Vector-borne diseases |
| title | Variable immunogenicity of a vivax malaria blood-stage vaccine candidate |
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