Type 2 Diabetes, Metabolic Traits, and Risk of Heart Failure: A Mendelian Randomization Study

The aim of this study was to use Mendelian randomization (MR) techniques to estimate the causal relationships between genetic liability to type 2 diabetes (T2D), glycemic traits, and risk of heart failure (HF). Summary-level data were obtained from genome-wide association studies of T2D, insulin res...

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Veröffentlicht in:	Diabetes care 2021-07, Vol.44 (7), p.1699-1705
Hauptverfasser:	Mordi, Ify R, Lumbers, R Thomas, Palmer, Colin N A, Pearson, Ewan R, Sattar, Naveed, Holmes, Michael V, Lang, Chim C
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood pressure Cardiovascular and Metabolic Risk Cholesterol Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Etiology Fasting Genome-Wide Association Study Genomes Glucose Health risks Heart diseases Heart failure Heart Failure - etiology Heart Failure - genetics Hemoglobin Humans Insulin Insulin resistance Laboratory testing Liability Low density lipoprotein Mendelian Randomization Analysis Pleiotropy Polymorphism, Single Nucleotide Randomization Research design Risk Risk Factors Sensitivity analysis Variance analysis
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