Slug promotes p53 and p21 protein degradation by inducing Mdm2 expression in HCT116 colon cancer cells

Our previous study revealed that the tumor suppressor/transcription factor p53 directly binds to its transcriptional target, p21, and that the p53/p21 complex binds to zinc finger protein SNAI2 (Slug), a tumor promoter/transcription factor; thereby promoting the degradation of Slug by Mdm2, an E3 li...

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Veröffentlicht in:	Oncology letters 2021-09, Vol.22 (3), p.1, Article 681
Hauptverfasser:	Kim, Jongdoo, Lee, Jihyun, Kim, Ukjin, Park, Jong-Kuk, Um, Hong-Duck
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Biotechnology Cancer cells Colon cancer Colorectal cancer DNA binding proteins Influence Ligases Lung cancer Protein binding Proteins Proteolysis RNA Tumor proteins Ubiquitin
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