Further Investigations into Rigidity‐Activity Relationships in BisQAC Amphiphilic Antiseptics

Thirty‐six biscationic quaternary ammonium compounds were efficiently synthesized in one step to examine the effect of molecular geometry of two‐carbon linkers on antimicrobial activity. The synthesized compounds showed strong antimicrobial activity against a panel of both Gram‐positive and Gram‐neg...

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Veröffentlicht in:	ChemMedChem 2020-04, Vol.15 (8), p.667-670
Hauptverfasser:	Leitgeb, Austin J., Feliciano, Javier A., Sanchez, Hugo A., Allen, Ryan A., Morrison, Kelly R., Sommers, Kyle J., Carden, Robert G., Wuest, William M., Minbiole, Kevin P. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ammonium Ammonium compounds Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antiinfectives and antibacterials Antimicrobial activity Antimicrobial agents Antiseptics bisQACs Dose-Response Relationship, Drug Drug resistance Gram-negative bacteria Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Methicillin methicillin-resistant Staphylococcus aureus (MRSA) Microbial Sensitivity Tests Minimum inhibitory concentration Molecular Structure Quaternary ammonium compounds Quaternary Ammonium Compounds - chemical synthesis Quaternary Ammonium Compounds - chemistry Quaternary Ammonium Compounds - pharmacology Quaternary ammonium salts Rigidity Staphylococcus aureus Surface-Active Agents - chemical synthesis Surface-Active Agents - chemistry Surface-Active Agents - pharmacology
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