Computational Fluid Dynamics of Intraocular Silicone Oil Tamponade

PurposeTo investigate the behavior of silicone oil (SiO) at the steady equilibrium and during saccades and calculate SiO-retina contact, shear stress (SS), and shear rate (SR). MethodsA 24 mm phakic eye mesh model underwent 50°/0.137s saccade. The vitreous chamber compartment was divided into superi...

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Veröffentlicht in:Translational vision science & technology 2021-07, Vol.10 (8), p.22-22
Hauptverfasser: Rossi, Tommaso, Querzoli, Giorgio, Badas, Maria Grazia, Angius, Federico, Telani, Serena, Ripandelli, Guido
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container_issue 8
container_start_page 22
container_title Translational vision science & technology
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creator Rossi, Tommaso
Querzoli, Giorgio
Badas, Maria Grazia
Angius, Federico
Telani, Serena
Ripandelli, Guido
description PurposeTo investigate the behavior of silicone oil (SiO) at the steady equilibrium and during saccades and calculate SiO-retina contact, shear stress (SS), and shear rate (SR). MethodsA 24 mm phakic eye mesh model underwent 50°/0.137s saccade. The vitreous chamber compartment was divided into superior and inferior 180° sectors: lens, pre-equator, postequator, and macula. SiO-retina contact was evaluated as a function of fill percentages between 80% and 90% for a standing patient, 45° upward gaze, and supine. SS and SR for 1000 mPa-s (SiO1000) and 5000 mPa-s (SiO5000) silicon oil were calculated. ResultsSiO fill between 80% to 90% allowed 55% to 78% retinal contact. The superior retina always kept better contact with SiO, regardless of the fill percentage (P < 0.01). SiO interface thoroughly contacted the macula only in standing position. SS followed a bimodal behavior and was always significantly higher for SiO5000 compared to SiO1000 (P < 0.01) throughout the saccade. The macula suffered the highest mean SS in standing position, while throughout the saccade the average SS was maximum at the SiO-aqueous interface. SR was significantly higher for SiO1000 compared to SiO5000 (P < 0.001). ConclusionsSS on the retinal surface may instantaneously exceed reported retinal adhesiveness values especially at the SiO-aqueous interface and possibly favor redetachment. Despite 90% SiO fill the inferior retina remains extremely difficult to tamponade. Translational RelevanceAccurate assessment of retina-tamponade interaction may explain recurrent inferior retinal redetachment, silicone oil emulsification, and help to develop better vitreous substitutes.
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MethodsA 24 mm phakic eye mesh model underwent 50°/0.137s saccade. The vitreous chamber compartment was divided into superior and inferior 180° sectors: lens, pre-equator, postequator, and macula. SiO-retina contact was evaluated as a function of fill percentages between 80% and 90% for a standing patient, 45° upward gaze, and supine. SS and SR for 1000 mPa-s (SiO1000) and 5000 mPa-s (SiO5000) silicon oil were calculated. ResultsSiO fill between 80% to 90% allowed 55% to 78% retinal contact. The superior retina always kept better contact with SiO, regardless of the fill percentage (P &lt; 0.01). SiO interface thoroughly contacted the macula only in standing position. SS followed a bimodal behavior and was always significantly higher for SiO5000 compared to SiO1000 (P &lt; 0.01) throughout the saccade. The macula suffered the highest mean SS in standing position, while throughout the saccade the average SS was maximum at the SiO-aqueous interface. SR was significantly higher for SiO1000 compared to SiO5000 (P &lt; 0.001). ConclusionsSS on the retinal surface may instantaneously exceed reported retinal adhesiveness values especially at the SiO-aqueous interface and possibly favor redetachment. Despite 90% SiO fill the inferior retina remains extremely difficult to tamponade. Translational RelevanceAccurate assessment of retina-tamponade interaction may explain recurrent inferior retinal redetachment, silicone oil emulsification, and help to develop better vitreous substitutes.</description><identifier>ISSN: 2164-2591</identifier><identifier>EISSN: 2164-2591</identifier><identifier>DOI: 10.1167/tvst.10.8.22</identifier><identifier>PMID: 34313726</identifier><language>eng</language><publisher>The Association for Research in Vision and Ophthalmology</publisher><ispartof>Translational vision science &amp; technology, 2021-07, Vol.10 (8), p.22-22</ispartof><rights>Copyright 2021 The Authors 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-5d30399daf497d96f1b2a9cf5e9f30e8508c447aa9b16569e86227a5c13973bc3</citedby><cites>FETCH-LOGICAL-c361t-5d30399daf497d96f1b2a9cf5e9f30e8508c447aa9b16569e86227a5c13973bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322710/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322710/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Rossi, Tommaso</creatorcontrib><creatorcontrib>Querzoli, Giorgio</creatorcontrib><creatorcontrib>Badas, Maria Grazia</creatorcontrib><creatorcontrib>Angius, Federico</creatorcontrib><creatorcontrib>Telani, Serena</creatorcontrib><creatorcontrib>Ripandelli, Guido</creatorcontrib><title>Computational Fluid Dynamics of Intraocular Silicone Oil Tamponade</title><title>Translational vision science &amp; technology</title><description>PurposeTo investigate the behavior of silicone oil (SiO) at the steady equilibrium and during saccades and calculate SiO-retina contact, shear stress (SS), and shear rate (SR). MethodsA 24 mm phakic eye mesh model underwent 50°/0.137s saccade. The vitreous chamber compartment was divided into superior and inferior 180° sectors: lens, pre-equator, postequator, and macula. SiO-retina contact was evaluated as a function of fill percentages between 80% and 90% for a standing patient, 45° upward gaze, and supine. SS and SR for 1000 mPa-s (SiO1000) and 5000 mPa-s (SiO5000) silicon oil were calculated. ResultsSiO fill between 80% to 90% allowed 55% to 78% retinal contact. The superior retina always kept better contact with SiO, regardless of the fill percentage (P &lt; 0.01). SiO interface thoroughly contacted the macula only in standing position. SS followed a bimodal behavior and was always significantly higher for SiO5000 compared to SiO1000 (P &lt; 0.01) throughout the saccade. The macula suffered the highest mean SS in standing position, while throughout the saccade the average SS was maximum at the SiO-aqueous interface. SR was significantly higher for SiO1000 compared to SiO5000 (P &lt; 0.001). ConclusionsSS on the retinal surface may instantaneously exceed reported retinal adhesiveness values especially at the SiO-aqueous interface and possibly favor redetachment. Despite 90% SiO fill the inferior retina remains extremely difficult to tamponade. Translational RelevanceAccurate assessment of retina-tamponade interaction may explain recurrent inferior retinal redetachment, silicone oil emulsification, and help to develop better vitreous substitutes.</description><issn>2164-2591</issn><issn>2164-2591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpVkMFOwzAMhiMEYtPYjQfIkQMdTdKkzQUJBoNJk3ZgnCM3TSEobUrTTtrb02oTAl_sX_792TJC1yReECLSu24fusUgsgWlZ2hKiUgiyiU5_1NP0DyEr3gIkfEkEZdowhJGWErFFD0ufdX0HXTW1-DwyvW2wE-HGiqrA_YlXtddC173Dlr8Zp3VvjZ4ax3eQdUMM4W5QhcluGDmpzxD76vn3fI12mxf1suHTaSZIF3ECxYzKQsoE5kWUpQkpyB1yY0sWWwyHmc6SVIAmRPBhTSZoDQFrgmTKcs1m6H7I7fp88oU2oyXOdW0toL2oDxY9b9T20_14fcqYwOIxAPg5gRo_XdvQqcqG7RxDmrj-6Ao51ywVBIxWG-PVt36EFpT_q4hsRo_r8bPjyJTlLIfv5N2OA</recordid><startdate>20210727</startdate><enddate>20210727</enddate><creator>Rossi, Tommaso</creator><creator>Querzoli, Giorgio</creator><creator>Badas, Maria Grazia</creator><creator>Angius, Federico</creator><creator>Telani, Serena</creator><creator>Ripandelli, Guido</creator><general>The Association for Research in Vision and Ophthalmology</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210727</creationdate><title>Computational Fluid Dynamics of Intraocular Silicone Oil Tamponade</title><author>Rossi, Tommaso ; Querzoli, Giorgio ; Badas, Maria Grazia ; Angius, Federico ; Telani, Serena ; Ripandelli, Guido</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-5d30399daf497d96f1b2a9cf5e9f30e8508c447aa9b16569e86227a5c13973bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rossi, Tommaso</creatorcontrib><creatorcontrib>Querzoli, Giorgio</creatorcontrib><creatorcontrib>Badas, Maria Grazia</creatorcontrib><creatorcontrib>Angius, Federico</creatorcontrib><creatorcontrib>Telani, Serena</creatorcontrib><creatorcontrib>Ripandelli, Guido</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Translational vision science &amp; technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rossi, Tommaso</au><au>Querzoli, Giorgio</au><au>Badas, Maria Grazia</au><au>Angius, Federico</au><au>Telani, Serena</au><au>Ripandelli, Guido</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Computational Fluid Dynamics of Intraocular Silicone Oil Tamponade</atitle><jtitle>Translational vision science &amp; technology</jtitle><date>2021-07-27</date><risdate>2021</risdate><volume>10</volume><issue>8</issue><spage>22</spage><epage>22</epage><pages>22-22</pages><issn>2164-2591</issn><eissn>2164-2591</eissn><abstract>PurposeTo investigate the behavior of silicone oil (SiO) at the steady equilibrium and during saccades and calculate SiO-retina contact, shear stress (SS), and shear rate (SR). MethodsA 24 mm phakic eye mesh model underwent 50°/0.137s saccade. The vitreous chamber compartment was divided into superior and inferior 180° sectors: lens, pre-equator, postequator, and macula. SiO-retina contact was evaluated as a function of fill percentages between 80% and 90% for a standing patient, 45° upward gaze, and supine. SS and SR for 1000 mPa-s (SiO1000) and 5000 mPa-s (SiO5000) silicon oil were calculated. ResultsSiO fill between 80% to 90% allowed 55% to 78% retinal contact. The superior retina always kept better contact with SiO, regardless of the fill percentage (P &lt; 0.01). SiO interface thoroughly contacted the macula only in standing position. SS followed a bimodal behavior and was always significantly higher for SiO5000 compared to SiO1000 (P &lt; 0.01) throughout the saccade. The macula suffered the highest mean SS in standing position, while throughout the saccade the average SS was maximum at the SiO-aqueous interface. SR was significantly higher for SiO1000 compared to SiO5000 (P &lt; 0.001). ConclusionsSS on the retinal surface may instantaneously exceed reported retinal adhesiveness values especially at the SiO-aqueous interface and possibly favor redetachment. Despite 90% SiO fill the inferior retina remains extremely difficult to tamponade. Translational RelevanceAccurate assessment of retina-tamponade interaction may explain recurrent inferior retinal redetachment, silicone oil emulsification, and help to develop better vitreous substitutes.</abstract><pub>The Association for Research in Vision and Ophthalmology</pub><pmid>34313726</pmid><doi>10.1167/tvst.10.8.22</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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title Computational Fluid Dynamics of Intraocular Silicone Oil Tamponade
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