Therapeutic efficacy of anti-CD19 CAR-T cells in a mouse model of systemic lupus erythematosus

Dysregulated B-cell activation plays pivotal roles in systemic lupus erythematosus (SLE), which makes B-cell depletion a potential strategy for SLE treatment. The clinical success of anti-CD19 CAR-T cells in treating B-cell malignancies has attracted the attention of researchers. In this study, we a...

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Veröffentlicht in:	Cellular & molecular immunology 2021-08, Vol.18 (8), p.1896-1903
Hauptverfasser:	Jin, Xuexiao, Xu, Qin, Pu, Chengfei, Zhu, Kaixiang, Lu, Cheng, Jiang, Yu, Xiao, Lei, Han, Yongmei, Lu, Linrong
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/251 631/250/38 Adoptive transfer Animal models Animals Antibodies Antigens, CD19 Biomedical and Life Sciences Biomedicine CD19 antigen CD28 antigen Cell activation Cell therapy Disease Models, Animal Humans Immunology Lupus Lupus Erythematosus, Systemic - pathology Lupus Erythematosus, Systemic - therapy Lymphocytes Lymphocytes B Lymphocytes T Medical Microbiology Mice Mice, Inbred MRL lpr Microbiology Systemic lupus erythematosus T-Lymphocytes Vaccine
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