Cytomegalovirus mediates expansion of IL-15-responsive innate-memory cells with SIV killing function

Interindividual immune variability is driven predominantly by environmental factors, including exposure to chronic infectious agents such as cytomegalovirus (CMV). We investigated the effects of rhesus CMV (RhCMV) on composition and function of the immune system in young macaques. Within months of i...

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Veröffentlicht in:	The Journal of clinical investigation 2021-08, Vol.131 (15)
Hauptverfasser:	Méndez-Lagares, Gema, Chin, Ning, Chang, W L William, Lee, Jaewon, Rosás-Umbert, Míriam, Kieu, Hung T, Merriam, David, Lu, Wenze, Kim, Sungjin, Adamson, Lourdes, Brander, Christian, Luciw, Paul A, Barry, Peter A, Hartigan-O'Connor, Dennis J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD8-Positive T-Lymphocytes - immunology Cytomegalovirus - immunology Female Immunity, Innate Immunologic Memory Interleukin-15 - immunology Killer Cells, Natural - immunology Macaca mulatta Male Simian Acquired Immunodeficiency Syndrome - immunology Simian Immunodeficiency Virus - immunology
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