Doxycycline host-directed therapy in human pulmonary tuberculosis

BACKGROUNDMatrix metalloproteinases (MMPs) are key regulators of tissue destruction in tuberculosis (TB) and may be targets for host-directed therapy. We conducted a phase II double-blind, randomized, controlled trial investigating doxycycline, a licensed broad-spectrum MMP inhibitor, in patients wi...

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Veröffentlicht in:	The Journal of clinical investigation 2021-08, Vol.131 (15)
Hauptverfasser:	Miow, Qing Hao, Vallejo, Andres F, Wang, Yu, Hong, Jia Mei, Bai, Chen, Teo, Felicia Sw, Wang, Alvin Dy, Loh, Hong Rong, Tan, Tuan Zea, Ding, Ying, She, Hoi Wah, Gan, Suay Hong, Paton, Nicholas I, Lum, Josephine, Tay, Alicia, Chee, Cynthia Be, Tambyah, Paul A, Polak, Marta E, Wang, Yee Tang, Singhal, Amit, Elkington, Paul T, Friedland, Jon S, Ong, Catherine Wm
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Clinical Medicine Collagenases - biosynthesis Double-Blind Method Doxycycline Doxycycline - administration & dosage Drug therapy Female Gene Expression Regulation, Enzymologic - drug effects Health aspects Host-bacteria relationships Humans Male Middle Aged Molecular targeted therapy Pulmonary tuberculosis RNA-Seq Testing Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - enzymology
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