Canonical features of human antibodies recognizing the influenza hemagglutinin trimer interface

Broadly reactive antibodies targeting the influenza A virus hemagglutinin (HA) head domain are thought to be rare and to require extensive somatic mutations or unusual structural features to achieve breadth against divergent HA subtypes. Here we describe common genetic and structural features of pro...

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Veröffentlicht in:	The Journal of clinical investigation 2021-08, Vol.131 (15), p.1-11
Hauptverfasser:	Zost, Seth J, Dong, Jinhui, Gilchuk, Iuliia M, Gilchuk, Pavlo, Thornburg, Natalie J, Bangaru, Sandhya, Kose, Nurgun, Finn, Jessica A, Bombardi, Robin, Soto, Cinque, Chen, Elaine C, Nargi, Rachel S, Sutton, Rachel E, Irving, Ryan P, Suryadevara, Naveenchandra, Westover, Jonna B, Carnahan, Robert H, Turner, Hannah L, Li, Sheng, Ward, Andrew B, Crowe, Jr, James E
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - immunology Antibodies, Viral - chemistry Antibodies, Viral - immunology Antigen-antibody reactions Antigens Avian flu Biomedical research Development and progression Epitopes Epitopes - chemistry Epitopes - immunology Genetic aspects Genetic diversity Glycoproteins Health aspects Hemagglutinin Glycoproteins, Influenza Virus - chemistry Hemagglutinin Glycoproteins, Influenza Virus - immunology Hemagglutinins Humans Immunization Immunological research Influenza Influenza A Influenza A Virus, H1N1 Subtype - chemistry Influenza A Virus, H1N1 Subtype - immunology Influenza vaccines Influenza Vaccines - chemistry Influenza Vaccines - immunology Mutation Peptides Prevention Structure Trimers Vaccines Viral antibodies Viral proteins Viruses
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