Fluorescent Probes with Unnatural Amino Acids to Monitor Proteasome Activity in Real-Time

The proteasome is an essential protein complex that, when dysregulated, can result in various diseases in eukaryotic cells. As such, understanding the enzymatic activity of the proteasome and what can alter it is crucial to elucidating its roles in these diseases. This can be done effectively by usi...

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Veröffentlicht in:	ACS chemical biology 2020-09, Vol.15 (9), p.2588-2596
Hauptverfasser:	Zerfas, Breanna L, Coleman, Rachel A, Salazar-Chaparro, Andres F, Macatangay, Nathaniel J, Trader, Darci J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Cell Line, Tumor Fluoresceins - chemistry Fluorescent Dyes - chemistry HEK293 Cells Humans Peptides - chemistry Peptides - metabolism Proteasome Endopeptidase Complex - chemistry Proteasome Endopeptidase Complex - metabolism Substrate Specificity
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