Association Between NEDD4L Variation and the Genetic Risk of Acute Appendicitis: A Multi-institutional Genome-Wide Association Study

IMPORTANCE: The familial aspect of acute appendicitis (AA) has been proposed, but its hereditary basis remains undetermined. OBJECTIVE: To identify genomic variants associated with AA. DESIGN, SETTING, AND PARTICIPANTS: This genome-wide association study, conducted from June 21, 2019, to February 4,...

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Veröffentlicht in:	Archives of surgery (Chicago. 1960) 2021-10, Vol.156 (10), p.917-923
Hauptverfasser:	Gaitanidis, Apostolos, Kaafarani, Haytham M. A, Christensen, Mathias A, Breen, Kerry, Mendoza, April, Fagenholz, Peter J, Velmahos, George C, Farhat, Maha R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Appendicitis Appendicitis - genetics Female Gene expression Genetic Predisposition to Disease - genetics Genome-Wide Association Study Genomes Genotype & phenotype Humans Male Middle Aged Nedd4 Ubiquitin Protein Ligases - genetics Online First Original Investigation Polymorphism, Single Nucleotide - genetics Retrospective Studies
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