Upregulation of CD38 expression on multiple myeloma cells by novel HDAC6 inhibitors is a class effect and augments the efficacy of daratumumab

Multiple myeloma (MM) is incurable, so there is a significant unmet need for effective therapy for patients with relapsed or refractory disease. This situation has not changed despite the recent approval of the anti-CD38 antibody daratumumab, one of the most potent agents in MM treatment. The effici...

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Veröffentlicht in:	Leukemia 2021-01, Vol.35 (1), p.201-214
Hauptverfasser:	García-Guerrero, Estefanía, Götz, Ralph, Doose, Sören, Sauer, Markus, Rodríguez-Gil, Alfonso, Nerreter, Thomas, Kortüm, K. Martin, Pérez-Simón, José A., Einsele, Hermann, Hudecek, Michael, Danhof, Sophia
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/106 13/31 14 14/63 38/90 692/699/1541/1990/804 692/700/565/1436/1437 692/700/565/251 ADP-ribosyl Cyclase 1 - genetics ADP-ribosyl Cyclase 1 - metabolism Antibodies Antibodies, Monoclonal - pharmacology Antibody-Dependent Cell Cytotoxicity - drug effects Antibody-Dependent Cell Cytotoxicity - immunology Antineoplastic Agents - pharmacology Cancer Research CD38 antigen Cell Line, Tumor Cell membranes Cellular proteins Critical Care Medicine Development and progression Drug Synergism Drug therapy Flow cytometry Gene expression Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Health aspects Hematology Histone deacetylase Histone Deacetylase 6 - antagonists & inhibitors Histone Deacetylase Inhibitors - pharmacology Histone Deacetylase Inhibitors - therapeutic use Humans Hydroxamic Acids - pharmacology Image resolution Immunophenotyping Immunotherapy Inhibitors Intensive Internal Medicine Lysis Medicine Medicine & Public Health Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Microscopy Models, Biological Monoclonal antibodies Multiple myeloma Multiple Myeloma - drug therapy Multiple Myeloma - genetics Multiple Myeloma - metabolism Oncology Polymerase chain reaction Pyrimidines - pharmacology Reverse transcription Ribonucleic acid RNA Stochasticity T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Targeted cancer therapy Up-regulation
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