Fractionation of soluble molybdenum-binding proteins from liver, kidney, plasma and erythrocytes from sheep supplemented with molybdenum
Five ewes were given a daily dose of 1.4 mg Mo/kg body weight as ammonium molybdate for 21 to 55 days. Plasma molybdenum concentrations increased considerably following the dosage, but no systematic changes were seen in the plasma copper concentrations. About 80 per cent of the molybdenum present in...
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| Veröffentlicht in: | Acta veterinaria scandinavica 1980-01, Vol.21 (3), p.428-437 |
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| container_title | Acta veterinaria scandinavica |
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| creator | Norheim, G Soeli, N.E Froeslie, A Mjoer-Grimsrudd, M. (Veterinaerinstituttet, Oslo (Norway)) |
| description | Five ewes were given a daily dose of 1.4 mg Mo/kg body weight as ammonium molybdate for 21 to 55 days. Plasma molybdenum concentrations increased considerably following the dosage, but no systematic changes were seen in the plasma copper concentrations. About 80 per cent of the molybdenum present in blood was found in plasma. With gel filtration it was shown that practically all of the molybdenum present in plasma and red cell heamolyzates was found in a fraction with molecular weight less than 1,500. Soluble proteins from liver and kidney cortex were separated into one high molecular weight fraction with mole-cular weight above 200,000 and a non-protein fraction with molecular weight less than 1,500. Significant correlations were found between the amounts of molybdenum present in the high molecular weight fraction and the molybdenum concentrations in liver and kidney |
| doi_str_mv | 10.1186/BF03546875 |
| format | Article |
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(Veterinaerinstituttet, Oslo (Norway))</creatorcontrib><title>Fractionation of soluble molybdenum-binding proteins from liver, kidney, plasma and erythrocytes from sheep supplemented with molybdenum</title><title>Acta veterinaria scandinavica</title><addtitle>Acta Vet Scand</addtitle><description>Five ewes were given a daily dose of 1.4 mg Mo/kg body weight as ammonium molybdate for 21 to 55 days. Plasma molybdenum concentrations increased considerably following the dosage, but no systematic changes were seen in the plasma copper concentrations. About 80 per cent of the molybdenum present in blood was found in plasma. With gel filtration it was shown that practically all of the molybdenum present in plasma and red cell heamolyzates was found in a fraction with molecular weight less than 1,500. Soluble proteins from liver and kidney cortex were separated into one high molecular weight fraction with mole-cular weight above 200,000 and a non-protein fraction with molecular weight less than 1,500. Significant correlations were found between the amounts of molybdenum present in the high molecular weight fraction and the molybdenum concentrations in liver and kidney</description><subject>Animals</subject><subject>Carrier Proteins - blood</subject><subject>Carrier Proteins - isolation & purification</subject><subject>Copper - blood</subject><subject>Erythrocytes - analysis</subject><subject>Female</subject><subject>Kidney - analysis</subject><subject>Liver - analysis</subject><subject>Molecular Weight</subject><subject>Molybdenum - administration & dosage</subject><subject>Molybdenum - blood</subject><subject>Molybdenum - metabolism</subject><subject>Protein Binding</subject><subject>Sheep - metabolism</subject><issn>0044-605X</issn><issn>1751-0147</issn><issn>1751-0147</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU9rFEEQxRtR4hq9eBSEPnkIGe3_PXsJaMiqEPCikFvT012z29rTPXbPRPYb5GM7YZcYL1UU78erKh5Cryl5T2mrPnzaEC6FarV8glZUS9oQKvRTtCJEiEYRefMcvaj15zIqwdQJOtFCKM7ECt1tinVTyMneF5x7XHOcuwh4yHHfeUjz0HQh-ZC2eCx5gpAq7ksecAy3UM7xr-AT7M_xGG0dLLbJYyj7aVey209wZOsOYMR1HscIA6QJPP4Tpt2jJS_Rs97GCq-O_RT92Fx9v_zSXH_7_PXy43Xj-JpNjfRedtQyDS1jbu1pb4ntqeicVtRxaCXtCGu5VoStRe_VunPSt4RBRxzjlp-ii4PvOHcDeLccU2w0YwmDLXuTbTD_KynszDbfmpZTrTlZDN4dDUr-PUOdzBCqgxhtgjxXoyXXnEmxgGcH0JVca4H-YQkl5j438y-3BX77-KwH9BjUor856L3Nxm5LqObmanmLciX5Xw3Yn9w</recordid><startdate>19800101</startdate><enddate>19800101</enddate><creator>Norheim, G</creator><creator>Soeli, N.E</creator><creator>Froeslie, A</creator><creator>Mjoer-Grimsrudd, M. 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With gel filtration it was shown that practically all of the molybdenum present in plasma and red cell heamolyzates was found in a fraction with molecular weight less than 1,500. Soluble proteins from liver and kidney cortex were separated into one high molecular weight fraction with mole-cular weight above 200,000 and a non-protein fraction with molecular weight less than 1,500. Significant correlations were found between the amounts of molybdenum present in the high molecular weight fraction and the molybdenum concentrations in liver and kidney</abstract><cop>England</cop><pub>BioMed Central</pub><pmid>7446324</pmid><doi>10.1186/BF03546875</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0044-605X |
| ispartof | Acta veterinaria scandinavica, 1980-01, Vol.21 (3), p.428-437 |
| issn | 0044-605X 1751-0147 1751-0147 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8317730 |
| source | MEDLINE; Springer Nature OA Free Journals; PubMed Central |
| subjects | Animals Carrier Proteins - blood Carrier Proteins - isolation & purification Copper - blood Erythrocytes - analysis Female Kidney - analysis Liver - analysis Molecular Weight Molybdenum - administration & dosage Molybdenum - blood Molybdenum - metabolism Protein Binding Sheep - metabolism |
| title | Fractionation of soluble molybdenum-binding proteins from liver, kidney, plasma and erythrocytes from sheep supplemented with molybdenum |
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