Atg5 knockdown induces age-dependent cardiomyopathy which can be rescued by repeated remote ischemic conditioning

Altered autophagy is implicated in several human cardiovascular diseases. Remote ischemic conditioning (RIC) is cardioprotective in multiple cardiovascular injury models and modifies autophagy signaling, but its effect in cardiomyopathy induced by gene manipulation has not been reported. To investig...

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Veröffentlicht in:	Basic research in cardiology 2021-12, Vol.116 (1), p.47-47, Article 47
Hauptverfasser:	Wang, Fangfei, He, Quan, Gao, Zhiqian, Redington, Andrew N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Autophagy Autophagy-Related Protein 5 - genetics Biochemical markers Body weight Cardiac function Cardiology Cardiomyopathies - genetics Cardiomyopathy Cardiovascular diseases Conditioning Echocardiography Flox Gene manipulation Genotype & phenotype Heart Ischemia Medicine Medicine & Public Health Mice Original Contribution Phagocytosis Phenotypes Proteins Reperfusion Signal Transduction Tamoxifen TOR protein
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