MAPK and Notch-Mediated Effects of Meso-Xanthin F199 Compounds on Proliferative Activity and Apoptosis of Human Melanocytes in Three-Dimensional Culture
Meso-Xanthin (Meso-Xanthin F199™) is a highly active antiaging injection drug of the latest generation. The main acting compound is fucoxanthin, supplemented with several growth factors, vitamins, and hyaluronic acid. Previous examination of fucoxanthin on melanocytes showed its ability to inhibit s...
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| creator | Saburina, Irina N. Zurina, Irina M. Kosheleva, Nastasia V. Gorkun, Anastasiya A. Volkova, Elena N. Grinakovskaya, Olga S. Rybakov, Anton S. Kaysheva, Anna L. Kopylov, Arthur T. Morozov, Sergey G. |
| description | Meso-Xanthin (Meso-Xanthin F199™) is a highly active antiaging injection drug of the latest generation. The main acting compound is fucoxanthin, supplemented with several growth factors, vitamins, and hyaluronic acid. Previous examination of fucoxanthin on melanocytes showed its ability to inhibit skin pigmentation through different signaling pathways focused on suppression of melanogenic-stimulating receptors. In turn, the anticancer property of fucoxanthin is realized through MAPK and PI3K pathways. We aimed to evaluate the effect of fucoxanthin and supplemented growth factors on melanocyte growth and transformation at a proteomic level. The effect of fucoxanthin on melanocytes cultivated in three-dimensional (3D) condition was examined using high-throughput proteomic and system biology approaches to disclose key molecular events of the targeted action. Our results demonstrated significant inhibition of cell differentiation and ubiquitination processes. We found that the negative regulation of PSME1 and PTGIS largely determines the inhibition of NF-κB and MAPK2. Besides, fucoxanthin selectively inhibits cell differentiation via negative regulation of Raf signaling and the upstream activation of IL-1 signaling. It is assumed that inhibition of Raf influences the Notch-4 signaling and switches off the MAPK/MAPK2 cascade. Blockage of MAPK/MAPK2 is feasible due to suppression of Ras and NF-κB by the addressed action of IKKB, IKK2, and TRAF6. Suggestively, Meso-Xanthin F199™ can manage processes of proliferative activity and inhibition of apoptosis due to composition of fucoxanthin and growth-stimulating factors, which may increase the risk of skin cancer development under certain condition. |
| doi_str_mv | 10.1155/2021/8463161 |
| format | Article |
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The main acting compound is fucoxanthin, supplemented with several growth factors, vitamins, and hyaluronic acid. Previous examination of fucoxanthin on melanocytes showed its ability to inhibit skin pigmentation through different signaling pathways focused on suppression of melanogenic-stimulating receptors. In turn, the anticancer property of fucoxanthin is realized through MAPK and PI3K pathways. We aimed to evaluate the effect of fucoxanthin and supplemented growth factors on melanocyte growth and transformation at a proteomic level. The effect of fucoxanthin on melanocytes cultivated in three-dimensional (3D) condition was examined using high-throughput proteomic and system biology approaches to disclose key molecular events of the targeted action. Our results demonstrated significant inhibition of cell differentiation and ubiquitination processes. We found that the negative regulation of PSME1 and PTGIS largely determines the inhibition of NF-κB and MAPK2. Besides, fucoxanthin selectively inhibits cell differentiation via negative regulation of Raf signaling and the upstream activation of IL-1 signaling. It is assumed that inhibition of Raf influences the Notch-4 signaling and switches off the MAPK/MAPK2 cascade. Blockage of MAPK/MAPK2 is feasible due to suppression of Ras and NF-κB by the addressed action of IKKB, IKK2, and TRAF6. Suggestively, Meso-Xanthin F199™ can manage processes of proliferative activity and inhibition of apoptosis due to composition of fucoxanthin and growth-stimulating factors, which may increase the risk of skin cancer development under certain condition.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2021/8463161</identifier><identifier>PMID: 34337053</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>1-Phosphatidylinositol 3-kinase ; Acids ; Anticancer properties ; Apoptosis ; Carotenoids ; Cell culture ; Cell cycle ; Cell differentiation ; Cell growth ; Chromatography ; Dermatologic agents ; Dermatology ; Differentiation (biology) ; Formulae, receipts, prescriptions ; Fucoxanthin ; Growth factors ; Health aspects ; Health risks ; Hyaluronic acid ; IKK2 protein ; Interleukin 1 ; Investigations ; MAP kinase ; Melanocytes ; Methods ; Mitogen-activated protein kinases ; NF-κB protein ; Organic pigments ; Pharmacology, Experimental ; Physiological aspects ; Pigmentation ; Process management ; Raf protein ; Receptor mechanisms ; Signal transduction ; Signaling ; Skin cancer ; Skin pigmentation ; Spheroids ; Switches ; TRAF6 protein ; Ubiquitination ; Vitamins</subject><ispartof>BioMed research international, 2021-07, Vol.2021, p.1-16</ispartof><rights>Copyright © 2021 Irina N. Saburina et al.</rights><rights>COPYRIGHT 2021 John Wiley & Sons, Inc.</rights><rights>Copyright © 2021 Irina N. Saburina et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Irina N. 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The main acting compound is fucoxanthin, supplemented with several growth factors, vitamins, and hyaluronic acid. Previous examination of fucoxanthin on melanocytes showed its ability to inhibit skin pigmentation through different signaling pathways focused on suppression of melanogenic-stimulating receptors. In turn, the anticancer property of fucoxanthin is realized through MAPK and PI3K pathways. We aimed to evaluate the effect of fucoxanthin and supplemented growth factors on melanocyte growth and transformation at a proteomic level. The effect of fucoxanthin on melanocytes cultivated in three-dimensional (3D) condition was examined using high-throughput proteomic and system biology approaches to disclose key molecular events of the targeted action. Our results demonstrated significant inhibition of cell differentiation and ubiquitination processes. We found that the negative regulation of PSME1 and PTGIS largely determines the inhibition of NF-κB and MAPK2. Besides, fucoxanthin selectively inhibits cell differentiation via negative regulation of Raf signaling and the upstream activation of IL-1 signaling. It is assumed that inhibition of Raf influences the Notch-4 signaling and switches off the MAPK/MAPK2 cascade. Blockage of MAPK/MAPK2 is feasible due to suppression of Ras and NF-κB by the addressed action of IKKB, IKK2, and TRAF6. Suggestively, Meso-Xanthin F199™ can manage processes of proliferative activity and inhibition of apoptosis due to composition of fucoxanthin and growth-stimulating factors, which may increase the risk of skin cancer development under certain condition.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>Acids</subject><subject>Anticancer properties</subject><subject>Apoptosis</subject><subject>Carotenoids</subject><subject>Cell culture</subject><subject>Cell cycle</subject><subject>Cell differentiation</subject><subject>Cell growth</subject><subject>Chromatography</subject><subject>Dermatologic agents</subject><subject>Dermatology</subject><subject>Differentiation (biology)</subject><subject>Formulae, receipts, prescriptions</subject><subject>Fucoxanthin</subject><subject>Growth factors</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Hyaluronic acid</subject><subject>IKK2 protein</subject><subject>Interleukin 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and Notch-Mediated Effects of Meso-Xanthin F199 Compounds on Proliferative Activity and Apoptosis of Human Melanocytes in Three-Dimensional Culture</title><author>Saburina, Irina N. ; Zurina, Irina M. ; Kosheleva, Nastasia V. ; Gorkun, Anastasiya A. ; Volkova, Elena N. ; Grinakovskaya, Olga S. ; Rybakov, Anton S. ; Kaysheva, Anna L. ; Kopylov, Arthur T. ; Morozov, Sergey G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-b58eec9e0d0142b5bbd0f504e43b723a0277c85180fe23ceb58830c32ad9cc203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>1-Phosphatidylinositol 3-kinase</topic><topic>Acids</topic><topic>Anticancer properties</topic><topic>Apoptosis</topic><topic>Carotenoids</topic><topic>Cell culture</topic><topic>Cell cycle</topic><topic>Cell differentiation</topic><topic>Cell growth</topic><topic>Chromatography</topic><topic>Dermatologic 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The main acting compound is fucoxanthin, supplemented with several growth factors, vitamins, and hyaluronic acid. Previous examination of fucoxanthin on melanocytes showed its ability to inhibit skin pigmentation through different signaling pathways focused on suppression of melanogenic-stimulating receptors. In turn, the anticancer property of fucoxanthin is realized through MAPK and PI3K pathways. We aimed to evaluate the effect of fucoxanthin and supplemented growth factors on melanocyte growth and transformation at a proteomic level. The effect of fucoxanthin on melanocytes cultivated in three-dimensional (3D) condition was examined using high-throughput proteomic and system biology approaches to disclose key molecular events of the targeted action. Our results demonstrated significant inhibition of cell differentiation and ubiquitination processes. We found that the negative regulation of PSME1 and PTGIS largely determines the inhibition of NF-κB and MAPK2. Besides, fucoxanthin selectively inhibits cell differentiation via negative regulation of Raf signaling and the upstream activation of IL-1 signaling. It is assumed that inhibition of Raf influences the Notch-4 signaling and switches off the MAPK/MAPK2 cascade. Blockage of MAPK/MAPK2 is feasible due to suppression of Ras and NF-κB by the addressed action of IKKB, IKK2, and TRAF6. Suggestively, Meso-Xanthin F199™ can manage processes of proliferative activity and inhibition of apoptosis due to composition of fucoxanthin and growth-stimulating factors, which may increase the risk of skin cancer development under certain condition.</abstract><cop>New York</cop><pub>Hindawi</pub><pmid>34337053</pmid><doi>10.1155/2021/8463161</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0003-2014-2535</orcidid><orcidid>https://orcid.org/0000-0002-2665-4972</orcidid><orcidid>https://orcid.org/0000-0003-4472-2016</orcidid><orcidid>https://orcid.org/0000-0002-3275-0215</orcidid><orcidid>https://orcid.org/0000-0002-1063-8345</orcidid><orcidid>https://orcid.org/0000-0002-7199-372X</orcidid><orcidid>https://orcid.org/0000-0001-5859-812X</orcidid><orcidid>https://orcid.org/0000-0001-5822-5729</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2314-6133 |
| ispartof | BioMed research international, 2021-07, Vol.2021, p.1-16 |
| issn | 2314-6133 2314-6141 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8315846 |
| source | PubMed Central Open Access; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection |
| subjects | 1-Phosphatidylinositol 3-kinase Acids Anticancer properties Apoptosis Carotenoids Cell culture Cell cycle Cell differentiation Cell growth Chromatography Dermatologic agents Dermatology Differentiation (biology) Formulae, receipts, prescriptions Fucoxanthin Growth factors Health aspects Health risks Hyaluronic acid IKK2 protein Interleukin 1 Investigations MAP kinase Melanocytes Methods Mitogen-activated protein kinases NF-κB protein Organic pigments Pharmacology, Experimental Physiological aspects Pigmentation Process management Raf protein Receptor mechanisms Signal transduction Signaling Skin cancer Skin pigmentation Spheroids Switches TRAF6 protein Ubiquitination Vitamins |
| title | MAPK and Notch-Mediated Effects of Meso-Xanthin F199 Compounds on Proliferative Activity and Apoptosis of Human Melanocytes in Three-Dimensional Culture |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T00%3A03%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=MAPK%20and%20Notch-Mediated%20Effects%20of%20Meso-Xanthin%20F199%20Compounds%20on%20Proliferative%20Activity%20and%20Apoptosis%20of%20Human%20Melanocytes%20in%20Three-Dimensional%20Culture&rft.jtitle=BioMed%20research%20international&rft.au=Saburina,%20Irina%20N.&rft.date=2021-07-20&rft.volume=2021&rft.spage=1&rft.epage=16&rft.pages=1-16&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2021/8463161&rft_dat=%3Cgale_pubme%3EA696876850%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2557139955&rft_id=info:pmid/34337053&rft_galeid=A696876850&rfr_iscdi=true |