Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation

Genome-wide association studies have uncovered over a 100 genetic loci associated with atrial fibrillation (AF), the most common arrhythmia. Many of the top AF-associated loci harbor key cardiac transcription factors, including PITX2, TBX5, PRRX1, and ZFHX3. Moreover, the vast majority of the AF-ass...

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Veröffentlicht in:	Circulation research 2020-06, Vol.127 (1), p.34-50
Hauptverfasser:	van Ouwerkerk, Antoinette F., Hall, Amelia W., Kadow, Zachary A., Lazarevic, Sonja, Reyat, Jasmeet S., Tucker, Nathan R., Nadadur, Rangarajan D., Bosada, Fernanda M., Bianchi, Valerio, Ellinor, Patrick T., Fabritz, Larissa, Martin, James F., de Laat, Wouter, Kirchhof, Paulus, Moskowitz, Ivan P., Christoffels, Vincent M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrial Fibrillation - genetics Atrial Fibrillation - metabolism Epigenesis, Genetic Gene Regulatory Networks Genetic Loci Humans Transcriptome
Online-Zugang:	Volltext
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