GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy

Radiotherapy is one of the curative treatment options for localized prostate cancer (PCa). The curative potential of radiotherapy is mediated by irradiation-induced oxidative stress and DNA damage in tumor cells. However, PCa radiocurability can be impeded by tumor resistance mechanisms and normal t...

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Veröffentlicht in:	Theranostics 2021-01, Vol.11 (16), p.7844-7868
Hauptverfasser:	Mukha, Anna, Kahya, Uğur, Linge, Annett, Chen, Oleg, Löck, Steffen, Lukiyanchuk, Vasyl, Richter, Susan, Alves, Tiago C, Peitzsch, Mirko, Telychko, Vladyslav, Skvortsov, Sergej, Negro, Giulia, Aschenbrenner, Bertram, Skvortsova, Ira-Ida, Mirtschink, Peter, Lohaus, Fabian, Hölscher, Tobias, Neubauer, Hans, Rivandi, Mahdi, Labitzky, Vera, Lange, Tobias, Franken, André, Behrens, Bianca, Stoecklein, Nikolas H, Toma, Marieta, Sommer, Ulrich, Zschaeck, Sebastian, Rehm, Maximilian, Eisenhofer, Graeme, Schwager, Christian, Abdollahi, Amir, Groeben, Christer, Kunz-Schughart, Leoni A, Baretton, Gustavo B, Baumann, Michael, Krause, Mechthild, Peitzsch, Claudia, Dubrovska, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Autophagy Autophagy-Related Protein 5 - metabolism Biomarkers Biomarkers, Pharmacological Biosynthesis Cancer therapies Cell Line, Tumor Epigenetics Gene expression Glutaminase - antagonists & inhibitors Glutaminase - genetics Glutaminase - metabolism Glutamine - metabolism Humans Male Metabolism Metabolites Mice Mice, Nude Neoplastic Stem Cells - metabolism Oxidation-Reduction Prostate cancer Prostatic Neoplasms - metabolism Proto-Oncogene Proteins c-myc - metabolism Radiation therapy Radiation Tolerance - genetics Reactive oxygen species Reactive Oxygen Species - metabolism Research Paper Respiration Stem cells Tumors Xenograft Model Antitumor Assays
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