Episodic Aspiration with Oral Commensals Induces a MyD88-dependent, Pulmonary T-Helper Cell Type 17 Response that Mitigates Susceptibility to Streptococcus pneumoniae

Cross-sectional human data suggest that enrichment of oral anaerobic bacteria in the lung is associated with an increased T-helper cell type 17 (Th17) inflammatory phenotype. In this study, we evaluated the microbial and host immune-response dynamics after aspiration with oral commensals using a pre...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2021-05, Vol.203 (9), p.1099-1111
Hauptverfasser:	Wu, Benjamin G, Sulaiman, Imran, Tsay, Jun-Chieh J, Perez, Luisanny, Franca, Brendan, Li, Yonghua, Wang, Jing, Gonzalez, Amber N, El-Ashmawy, Mariam, Carpenito, Joseph, Olsen, Evan, Sauthoff, Maya, Yie, Kevin, Liu, Xiuxiu, Shen, Nan, Clemente, Jose C, Kapoor, Bianca, Zangari, Tonia, Mezzano, Valeria, Loomis, Cynthia, Weiden, Michael D, Koralov, Sergei B, D'Armiento, Jeanine, Ahuja, Sunil K, Wu, Xue-Ru, Weiser, Jeffrey N, Segal, Leopoldo N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Female Humans Immune system Mice Mice, Inbred C57BL Myeloid Differentiation Factor 88 - physiology Original Pathogens Pneumococcal Infections - etiology Pneumococcal Infections - prevention & control Pneumonia Prevotella melaninogenica Pulmonary aspiration Streptococcus infections Streptococcus mitis Streptococcus pneumoniae Th17 Cells - physiology Veillonella
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