Palbociclib Renders Human Papilloma Virus-Negative Head and Neck Squamous Cell Carcinoma Vulnerable to the Senolytic Agent Navitoclax

We demonstrate that inhibition of cyclin-dependent kinases 4/6 (CDK4/6) leads to senescence in human papillomavirus (HPV)-negative (-) head and neck squamous cell carcinoma (HNSCC), but not in HPV-positive (+) HNSCC. The BCL-2 family inhibitor, navitoclax, has been shown to eliminate senescent cells...

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Veröffentlicht in:	Molecular cancer research 2021-05, Vol.19 (5), p.862-873
Hauptverfasser:	Gadsden, Nicholas J, Fulcher, Cory D, Li, Daniel, Shrivastava, Nitisha, Thomas, Carlos, Segall, Jeffrey E, Prystowsky, Michael B, Schlecht, Nicolas F, Gavathiotis, Evripidis, Ow, Thomas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - administration & dosage Aniline Compounds - pharmacology Antineoplastic Combined Chemotherapy Protocols - pharmacology Cell Line, Tumor Drug Synergism Head and Neck Neoplasms - drug therapy Humans Piperazines - administration & dosage Piperazines - pharmacology Pyridines - administration & dosage Pyridines - pharmacology Squamous Cell Carcinoma of Head and Neck - drug therapy Sulfonamides - administration & dosage Sulfonamides - pharmacology
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