Suppression of the solar ultraviolet-induced skin carcinogenesis by TOPK inhibitor HI-TOPK-032

Nonmelanoma skin cancer (NMSC) such as cutaneous squamous cell carcinoma (cSCC) is caused by solar ultraviolet (SUV) exposure and is the most common cancer in the United States. T-LAK cell-originated protein kinase (TOPK), a serine-threonine kinase is activated by SUV irradiation and involved in ski...

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Veröffentlicht in:	Oncogene 2020-05, Vol.39 (21), p.4170-4182
Hauptverfasser:	Roh, Eunmiri, Han, Yaping, Reddy, Kanamata, Zykova, Tatyana A., Lee, Mee Hyun, Yao, Ke, Bai, Ruihua, Curiel-Lewandrowski, Clara, Dong, Zigang
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 13/95 14/105 14/34 38/109 38/70 38/89 45/70 631/67/1813/1352 631/67/395 64/60 82/1 82/16 82/29 82/51 82/80 82/83 Agricultural industry Animals Apoptosis c-Jun protein Cancer Carcinogenesis Carcinogenesis - drug effects Carcinogenesis - genetics Carcinogenesis - metabolism Carcinogenesis - radiation effects Care and treatment Cell Biology Cell proliferation Dermatologic agents Dermatology Drug therapy Formulae, receipts, prescriptions Hairless Human Genetics Humans Indolizines - pharmacology Inflammation Internal Medicine Kinases Medicine Medicine & Public Health Melanoma Mice Mice, Hairless Mice, Knockout Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - metabolism Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Oncology Phosphorylation Prevention Protein kinase Protein Kinase Inhibitors - pharmacology Protein kinases Protein-serine/threonine kinase Quinoxalines - pharmacology Signal transduction Skin Skin cancer Skin Neoplasms - drug therapy Skin Neoplasms - enzymology Skin Neoplasms - genetics Skin Neoplasms - pathology Sport-utility vehicles Squamous cell carcinoma Sunlight - adverse effects Topical application Transcription factors Ultraviolet Rays - adverse effects
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