Next-Generation Sequencing in Cancer
Objective In this article, we provide a gestalt idea about NGS technologies and their applications in cancer research and molecular diagnosis. Background Next-generation sequencing (NGS) advancements like DNA sequencing and RNA sequencing allow uncovering of genomic, transcriptomic, and epigenomic s...
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| Veröffentlicht in: | Journal of maxillofacial and oral surgery 2021-09, Vol.20 (3), p.340-344 |
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| container_title | Journal of maxillofacial and oral surgery |
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| creator | Nair, S. Vinod Madhulaxmi Thomas, Gigi Ankathil, Ravindran |
| description | Objective
In this article, we provide a gestalt idea about NGS technologies and their applications in cancer research and molecular diagnosis.
Background
Next-generation sequencing (NGS) advancements like DNA sequencing and RNA sequencing allow uncovering of genomic, transcriptomic, and epigenomic scenes of individual malignant growths. An assortment of genomic abnormalities can be screened at the same time, for example common and uncommon variations, auxiliary variations like insertions and deletions, copy-number variation, and fusion transcripts.
Conclusion
NGS innovations together with bioinformatics investigation, which extend our insight, are progressively used to analyze multiple genes in a cost-effective way and have been applied in examining clinical cancer samples and offering NGS-based molecular diagnosis.
Application
NGS is progressively significant as a device for the diagnosis of cancers. |
| doi_str_mv | 10.1007/s12663-020-01462-4 |
| format | Article |
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In this article, we provide a gestalt idea about NGS technologies and their applications in cancer research and molecular diagnosis.
Background
Next-generation sequencing (NGS) advancements like DNA sequencing and RNA sequencing allow uncovering of genomic, transcriptomic, and epigenomic scenes of individual malignant growths. An assortment of genomic abnormalities can be screened at the same time, for example common and uncommon variations, auxiliary variations like insertions and deletions, copy-number variation, and fusion transcripts.
Conclusion
NGS innovations together with bioinformatics investigation, which extend our insight, are progressively used to analyze multiple genes in a cost-effective way and have been applied in examining clinical cancer samples and offering NGS-based molecular diagnosis.
Application
NGS is progressively significant as a device for the diagnosis of cancers.</description><identifier>ISSN: 0972-8279</identifier><identifier>EISSN: 0974-942X</identifier><identifier>DOI: 10.1007/s12663-020-01462-4</identifier><identifier>PMID: 34408360</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Adjustment ; Biopsy ; Cancer research ; Dentistry ; Disease ; DNA methylation ; Epigenetics ; Genes ; Genetic engineering ; Genetic testing ; Genomes ; Industrialized nations ; Medical research ; Medicine ; Medicine & Public Health ; MicroRNAs ; Mutation ; Oral and Maxillofacial Surgery ; Otorhinolaryngology ; Plastic Surgery ; Review Paper ; Tumors</subject><ispartof>Journal of maxillofacial and oral surgery, 2021-09, Vol.20 (3), p.340-344</ispartof><rights>The Association of Oral and Maxillofacial Surgeons of India 2020</rights><rights>The Association of Oral and Maxillofacial Surgeons of India 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-883b49d08bf10ad1504dc2b21c88e5510fb2654aef3f39d9b39ca2f5509b93ca3</citedby><cites>FETCH-LOGICAL-c451t-883b49d08bf10ad1504dc2b21c88e5510fb2654aef3f39d9b39ca2f5509b93ca3</cites><orcidid>0000-0002-0391-0152</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313644/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2920430486?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,21367,27901,27902,33721,33722,41464,42533,43781,51294,53766,53768</link.rule.ids></links><search><creatorcontrib>Nair, S. Vinod</creatorcontrib><creatorcontrib>Madhulaxmi</creatorcontrib><creatorcontrib>Thomas, Gigi</creatorcontrib><creatorcontrib>Ankathil, Ravindran</creatorcontrib><title>Next-Generation Sequencing in Cancer</title><title>Journal of maxillofacial and oral surgery</title><addtitle>J. Maxillofac. Oral Surg</addtitle><description>Objective
In this article, we provide a gestalt idea about NGS technologies and their applications in cancer research and molecular diagnosis.
Background
Next-generation sequencing (NGS) advancements like DNA sequencing and RNA sequencing allow uncovering of genomic, transcriptomic, and epigenomic scenes of individual malignant growths. An assortment of genomic abnormalities can be screened at the same time, for example common and uncommon variations, auxiliary variations like insertions and deletions, copy-number variation, and fusion transcripts.
Conclusion
NGS innovations together with bioinformatics investigation, which extend our insight, are progressively used to analyze multiple genes in a cost-effective way and have been applied in examining clinical cancer samples and offering NGS-based molecular diagnosis.
Application
NGS is progressively significant as a device for the diagnosis of cancers.</description><subject>Adjustment</subject><subject>Biopsy</subject><subject>Cancer research</subject><subject>Dentistry</subject><subject>Disease</subject><subject>DNA methylation</subject><subject>Epigenetics</subject><subject>Genes</subject><subject>Genetic engineering</subject><subject>Genetic testing</subject><subject>Genomes</subject><subject>Industrialized nations</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>MicroRNAs</subject><subject>Mutation</subject><subject>Oral and Maxillofacial Surgery</subject><subject>Otorhinolaryngology</subject><subject>Plastic Surgery</subject><subject>Review Paper</subject><subject>Tumors</subject><issn>0972-8279</issn><issn>0974-942X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kU9LAzEQxYMottR-AU8FPXiJTv5smlwEKVqFogcVvIVsNlu3tNma7Ip-e9NuUfTgXGZgfvOYx0PomMA5ARhfREKFYBgoYCBcUMz3UB_UmGPF6cv-dqZY0rHqoWGMC0jFCFOMHKIe4xwkE9BHp_fuo8FT510wTVX70aN7a523lZ-PKj-aGG9dOEIHpVlGN9z1AXq-uX6a3OLZw_RucjXDlmekwVKynKsCZF4SMAXJgBeW5pRYKV2WEShzKjJuXMlKpgqVM2UNLbMMVK6YNWyALjvddZuvXGGdb4JZ6nWoViZ86tpU-vfGV696Xr9rmZwJzpPA2U4g1MlGbPSqitYtl8a7uo2aZoJKBiBpQk_-oIu6DT7Z01RR4Ay4FImiHWVDHWNw5fczBPQmB93loFMOepuD3nzBuqOYYD934Uf6n6svAoKHtA</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Nair, S. Vinod</creator><creator>Madhulaxmi</creator><creator>Thomas, Gigi</creator><creator>Ankathil, Ravindran</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0391-0152</orcidid></search><sort><creationdate>20210901</creationdate><title>Next-Generation Sequencing in Cancer</title><author>Nair, S. Vinod ; Madhulaxmi ; Thomas, Gigi ; Ankathil, Ravindran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-883b49d08bf10ad1504dc2b21c88e5510fb2654aef3f39d9b39ca2f5509b93ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adjustment</topic><topic>Biopsy</topic><topic>Cancer research</topic><topic>Dentistry</topic><topic>Disease</topic><topic>DNA methylation</topic><topic>Epigenetics</topic><topic>Genes</topic><topic>Genetic engineering</topic><topic>Genetic testing</topic><topic>Genomes</topic><topic>Industrialized nations</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>MicroRNAs</topic><topic>Mutation</topic><topic>Oral and Maxillofacial Surgery</topic><topic>Otorhinolaryngology</topic><topic>Plastic Surgery</topic><topic>Review Paper</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nair, S. Vinod</creatorcontrib><creatorcontrib>Madhulaxmi</creatorcontrib><creatorcontrib>Thomas, Gigi</creatorcontrib><creatorcontrib>Ankathil, Ravindran</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of maxillofacial and oral surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nair, S. 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In this article, we provide a gestalt idea about NGS technologies and their applications in cancer research and molecular diagnosis.
Background
Next-generation sequencing (NGS) advancements like DNA sequencing and RNA sequencing allow uncovering of genomic, transcriptomic, and epigenomic scenes of individual malignant growths. An assortment of genomic abnormalities can be screened at the same time, for example common and uncommon variations, auxiliary variations like insertions and deletions, copy-number variation, and fusion transcripts.
Conclusion
NGS innovations together with bioinformatics investigation, which extend our insight, are progressively used to analyze multiple genes in a cost-effective way and have been applied in examining clinical cancer samples and offering NGS-based molecular diagnosis.
Application
NGS is progressively significant as a device for the diagnosis of cancers.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>34408360</pmid><doi>10.1007/s12663-020-01462-4</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-0391-0152</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; ProQuest Central |
| subjects | Adjustment Biopsy Cancer research Dentistry Disease DNA methylation Epigenetics Genes Genetic engineering Genetic testing Genomes Industrialized nations Medical research Medicine Medicine & Public Health MicroRNAs Mutation Oral and Maxillofacial Surgery Otorhinolaryngology Plastic Surgery Review Paper Tumors |
| title | Next-Generation Sequencing in Cancer |
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